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. 2010 Nov 9;8(11):1899. doi: 10.2903/j.efsa.2010.1899

Scientific Opinion on Flavouring Group Evaluation 81 (FGE.81): Consideration of hydroxypropenylbenzenes evaluated by JECFA (61st meeting) structurally related to 2‐methoxy‐4‐(prop‐1‐enyl)phenyl 3‐methylbutyrate from chemical group 17 evaluated by EFSA in FGE.30

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
PMCID: PMC13130013  PMID: 42079555

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EFSA ; Scientific Opinion on Flavouring Group Evaluation 81 (FGE.81): Consideration of hydroxypropenylbenzenes evaluated by JECFA (61st meeting) structurally related to 2‐methoxy‐4‐(prop‐1‐enyl)phenyl 3‐methylbutyrate from chemical group 17 evaluated by EFSA in FGE.30. EFSA Journal 2010;8(11):1899. [25 pp.]. doi: 10.2903/j.efsa.2010.1899

Panel members: Arturo Anadon, David Bell, Mona‐Lise Binderup, Wilfried Bursch, Laurence Castle, Riccardo Crebelli, Karl‐Heinz Engel, Roland Franz, Nathalie Gontard, Thomas Haertle, Trine Husøy, Klaus‐Dieter Jany, Catherine Leclercq, Jean Claude Lhuguenot, Wim Mennes, Maria Rosaria Milana, Karla Pfaff, Kettil Svensson, Fidel Toldra, Rosemary Waring, Detlef Wölfle

Correspondence: CEF-Unit@efsa.europa.eu

Acknowledgement: The Panel wishes to thank the members of the Working Groups on Flavourings for the preparation of this Opinion: wishes to thank the members of the Working Groups on Flavourings for the preparation of this Opinion:Ulla Beckman Sundh, Vibe Beltoft, Wilfried Bursch, Angelo Carere, Karl‐Heinz Engel, Henrik Frandsen, Jørn Gry, Rainer Gürtler, Frances Hill, Trine Husøy, John Christian Larsen, Pia Lund, Wim Mennes, Gerard Mulder, Karin Nørby, Gerard Pascal, Iona Pratt, Gerrit Speijers, Harriet Wallin and EFSA's staff member Kim Rygaard Nielsen for the support provided to this EFSA scientific output.

Adoption date: 28 January 2010

Published date: 9 November 2010

Question number: EFSA‐Q‐2008‐065

On request from: European Commission

References

  1. Bradley, M.O. , Taylor, V.L. , Armstrong, M.J. , Galloway, S.M. , 1987. Relationship among cytotoxicity, lysosomal breakdown, chromosome aberrations and DNA double‐strand breaks. Mutat. Res. 189, 69–79. [DOI] [PubMed] [Google Scholar]
  2. Burkey, J.L. , Sauer, J.‐M. , McQueen, C.A. , Sipes, I.G. , 2000. Cytotoxicity and genotoxicity of methyleugenol and related congeners‐a mechanism of activation for methyleugenol. Mutat. Res. 453, 25–33. [DOI] [PubMed] [Google Scholar]
  3. Caldwell, J. , 1993. Perspective on the usefulness of the mouse lymphoma assay as an indicator of a genotoxic carcinogen: Ten compounds which are positive in the mouse lymphoma assay but are not genotoxic carcinogens. Teratog. Carcinog. Mutag. 13, 185–190. [DOI] [PubMed] [Google Scholar]
  4. Cifone, M.A. , 1983. Mutagenicity evaluation of vanitrope in the mouse lymphoma forward mutation assay. Final report. Litton Bionetics. LBI project no. 20989. January 1983. Unpublished report submitted by EFFA to FLAVIS Secretariat.
  5. Cifone, M.A. , 1988b. Mutagenicity test on vanitrope in the rat primary hepatocyte unscheduled DNA synthesis assay. Final report. Hazleton Laboratories Inc. HLA study no. 9995‐0‐447. March 9, 1988. Unpublished report submitted by EFFA to FLAVIS Secretariat.
  6. Cramer, G.M. , Ford, R.A. , Hall, R.L. , 1978. Estimation of toxic hazard ‐ a decision tree approach. Food Cosmet. Toxicol. 16(3), 255–276. [DOI] [PubMed] [Google Scholar]
  7. DeGraff, W.G. , 1983c. Mutagenicity evaluation of isoeugenol in the Ames Salmonella/microsome plate test. Final report. Litton Bionetics, Inc. LBI project no. 20988. November, 1983. Unpublished report submitted by EFFA to FLAVIS Secretariat. [Google Scholar]
  8. Douglas, G.R. , Nestmann, E.R. , Betts, J.L. , Mueller, J.C. , Lee, E.G.H. , Stich, H.F. , San, H.C. , Brouzes, R.J.P. , Chmelauskas, A.L. , Paavila, H.D. , Walden, C.C. , 1980. Mutagenic activity in pulp mill effluents. In: Jolley, R. L. , Brungs, W.A. , Cumming, R.B. , Jacobs, V.A. , (Eds.). Water Chlorination: Environmental Impact and Health Effects. vol. 3. Ann Arbor Science Publishers Inc., Ann Arbor, MI, pp. 865–880. [Google Scholar]
  9. EC , 1996a. Regulation No 2232/96 of the European Parliament and of the Council of 28 October 1996. Official Journal of the European Communities 23.11.1996, L 299, 1–4. [Google Scholar]
  10. EC , 1999a. Commission Decision 1999/217/EC of 23 February 1999 adopting a register of flavouring substances used in or on foodstuffs. Official Journal of the European Communities 27.3.1999, L 84, 1–137. [Google Scholar]
  11. EC , 2000a. Commission Regulation No 1565/2000 of 18 July 2000 laying down the measures necessary for the adoption of an evaluation programme in application of Regulation (EC) No 2232/96. Official Journal of the European Communities 19.7.2000, L 180, 8–16. [Google Scholar]
  12. EC , 2009a. Commission Decision 2009/163/EC of 26 February 2009 amending Decision 1999/217/EC as regards the Register of flavouring substances used in or on foodstuffs. Official Journal of the European Union 27.2.2009, L 55, 41. [Google Scholar]
  13. EFFA , 2010a. EFFA Letters to EFSA for clarification of specifications and isomerism for which data were requested in published FGEs
  14. EFSA , 2010s. Opinion of the Scientific Panel on Food contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 30 (FGE.30): Consideration of 2‐Methoxy‐4‐(prop‐1‐enyl)phenyl 3‐methylbutyrate from chemical group 17(Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 28 January 2010. EFSA‐Q‐2003‐173.
  15. EMEA (European Medicines Agency) , 2009. Information on unpublished data submitted to EFSA from EMEA.
  16. Florin, I. , Rutberg, L. , Curvall, M. , Enzell, C.R. , 1980. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology. 18, 219–232. [DOI] [PubMed] [Google Scholar]
  17. Fujita, H. , Sasaki, M. , 1987. [Mutagenicity test of food additives with Salmonella typhimurium TA97 and TA102]. Ann. Rep. Tokyo Metrop. Res. Lab. Public Health 38, 423–430. (In Japanese) [Google Scholar]
  18. Heck, J.D. , Vollmuth, T.A. , Cifone, M.A. , Jagannath, D.R. , Myhr, B. , Curren, R.D. , 1989. An evaluation of food flavoring ingredients in a genetic toxicity screening battery. Toxicologist 9(1), 257–272. [Google Scholar]
  19. Hsia, M.T.S. , Adamovics, J.A. , Kreamer, B.L. , 1979. Microbial mutagenicity studies of insect growth regulators and other potential insecticidal compounds in Salmonella Typhimurium . Chemosphere 8, 521–529. [Google Scholar]
  20. Jagannath, D.R. , 1982. Mutagenicity evaluation of vanitrope in the Ames Salmonella/microsome plate test. Final report. Bionetics. Genetics assay no. 6453. LBI safety no. 7901. September, 1982. Unpublished report submitted by EFFA to FLAVIS Secretariat.
  21. Jansson, T. , Curvall, M. , Hedin, A. , Enzell, C. , 1986. In vitro studies of biological effects of cigarette smoke condensate. II. Induction of sister‐chromatid in human lymphocytes by weakly acidic, semivolatile constituents. Mutat. Res. 169, 129–139. [DOI] [PubMed] [Google Scholar]
  22. JECFA , 1995. Evaluation of certain food additives and contaminants. Forty‐fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additives. 14–23 February 1995. WHO Technical Report Series, no. 859. Geneva. [Google Scholar]
  23. JECFA , 1996a. Toxicological evaluation of certain food additives. The forty‐fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives and contaminants. WHO Food Additives Series: 35. IPCS, WHO, Geneva. [Google Scholar]
  24. JECFA , 1997a. Evaluation of certain food additives and contaminants. Forty‐sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, 6–15 February 1996. WHO Technical Report Series, no. 868. Geneva. [PubMed] [Google Scholar]
  25. JECFA , 1999b. Evaluation of certain food additives and contaminants. Forty‐ninth report of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 17–26 June 1997. WHO Technical Report Series, no. 884. Geneva. [PubMed] [Google Scholar]
  26. JECFA , 2003b. Compendium of food additive specifications. Addendum 11. Joint FAO/WHO Expert Committee of Food Additives 61st session. Rome, 10–19 June 2003. FAO Food and Nutrition paper 52 Add. 11. [Google Scholar]
  27. JECFA , 2004b. Safety evaluation of certain food additives and contaminants. Sixty‐first meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 52. IPCS, WHO, Geneva. [Google Scholar]
  28. JECFA , 2006c. Joint FAO/WHO Expert Committee on Food Additives. Sixty‐seventh meeting. Rome, 20–29 June 2006, Summary and Conclusions. Issued 7 July 2006. [Google Scholar]
  29. Mortelmans, K. , Haworth, S. , Lawlor, T. , Speck, W. , Tainer, B. , Zeiger, E. , 1986. Salmonella mutagenicity tests II. Results from the testing of 270 chemicals. Environ. Mol. Mutag. 8(Suppl. 7), 1–119. [PubMed] [Google Scholar]
  30. NTP , 2008a. National Toxicology Program. Abstract of Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97‐54‐1) in F344/N Rats and B6C3F1 Mice (Gavage Studies), TR‐551. [Online] ntp.niehs.nih.gov/index.cfm?objectid=82FC6327‐F1F6‐975E‐759BAB1DDE7D9A32. [PubMed]
  31. Oda, Y. , Hamono, Y. , Inoue, K. , Yamamoto, H. , Niihara, T. , Kunita, N. , 1979. [Mutagenicity of food flavors in bacteria]. Shokuhin. Eisei. Hen. 9, 177–181. (In Japanese) [Google Scholar]
  32. Rockwell, P. , Raw, I. , 1979. A mutagenic screening of various herbs, spices and food additives. Nutr. Cancer 1(4), 10–15. [Google Scholar]
  33. San, R.H.C. , Reece, J.D. , 2003. Unscheduled DNA synthesis in mammalian cells in vitro. Study No. AA51FW‐FZ, AA52CV.380.BTL. BioReliance, Rockville, Maryland, USA. Unpublished report to the Research Institute for Fragrance Materials, Woodcliff Lake, New Jersey, USA. Submitted to WHO by the Flavor and Extract Manufacturers Association of the United States, Washington DC, USA. [Google Scholar]
  34. Sasaki, Y.F. , Imanishi, H. , Ohta, T. , Yasuhiko, S. , 1989. Modifying effects of components of plant essence on the induction of sister‐chromatid exchanges in cultured Chinese hamster ovary cells. Mutat. Res. 226, 103–110. [DOI] [PubMed] [Google Scholar]
  35. SCF , 1999. Opinion on a programme for the evaluation of flavouring substances (expressed on 2 December 1999). Scientific Committee on Food. SCF/CS/FLAV/TASK/11 Final 6/12/1999. Annex I the minutes of the 119th Plenary meeting. European Commission, Health & Consumer Protection Directorate‐General. [Google Scholar]
  36. Sekizawa, J. , Shibamoto, T. , 1982. Genotoxicity of safrole‐related chemicals in microbial test systems. Mutat. Res. 101, 127–140. [DOI] [PubMed] [Google Scholar]
  37. Solheim, E. , Scheline, R.R. , 1976. Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers. Xenobiotica 6(3), 137–150. [DOI] [PubMed] [Google Scholar]
  38. Wild, D. , King, M.T. , Gocke, E. , Eckhard, K. , 1983. Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, BASC and micronucleus tests. Food Chem. Toxicol. 21(6), 707–719. [DOI] [PubMed] [Google Scholar]
  39. Zaja‐Kaye, M. , Ts'o, P.O.P. , 1984. DNAase I encapsulation in liposomes can induce neoplastic transformation of Syrian hamster embryo cells in culture. Cell. 39, 427–437. [DOI] [PubMed] [Google Scholar]

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