Abstract
The relationship between risk factors and cardiovascular disease (CVD) was determined using data from the Nijmegen Cohort study, an 18-year prospective study. In 1977, cardiovascular risk factors were measured in 7092 Caucasian males and females from six general practices: age, smoking, serum cholesterol, blood pressure, body mass index and a family history of CVD were related to subsequent CVD mortality and morbidity. Most patients had more than one risk factor in particular among men. A significant relationship between risk factors and CVD was demonstrated. In men, a relative risk (RR) of 1.8 was found for both high blood pressure and smokers. A positive family history yielded a RR of 1.8. The risk increased gradually with the number of risk factors; 38% of the group with all risk factors suffered a CVD within 18 years. In women, comparable RRs were found but the low absolute risk of CVD should indicate against the treatment of cardiovascular risk factors.
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Selected References
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- Anderson K. M., Wilson P. W., Odell P. M., Kannel W. B. An updated coronary risk profile. A statement for health professionals. Circulation. 1991 Jan;83(1):356–362. doi: 10.1161/01.cir.83.1.356. [DOI] [PubMed] [Google Scholar]
- Bakx J. C., Stafleu A., van Staveren W. A., van den Hoogen H. J., van Weel C. Long-term effect of nutritional counseling: a study in family medicine. Am J Clin Nutr. 1997 Jun;65(6 Suppl):1946S–1950S. doi: 10.1093/ajcn/65.6.1946S. [DOI] [PubMed] [Google Scholar]
- Bakx J. C., van den Hoogen H. J., Deurenberg P., van Doremalen J., van den Bosch W. J. Changes in serum total cholesterol levels over 18 years in a cohort of men and women: The Nijmegen Cohort Study. Prev Med. 2000 Feb;30(2):138–145. doi: 10.1006/pmed.1999.0608. [DOI] [PubMed] [Google Scholar]
- Bonneux L., Barendregt J. J. Ook met de consensus over verlaging van de serumcholesterolconcentratie blijft primaire preventie duur. Ned Tijdschr Geneeskd. 1999 Apr 10;143(15):772–775. [PubMed] [Google Scholar]
- Chen Z., Peto R., Collins R., MacMahon S., Lu J., Li W. Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ. 1991 Aug 3;303(6797):276–282. doi: 10.1136/bmj.303.6797.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haq I. U., Jackson P. R., Yeo W. W., Ramsay L. E. Sheffield risk and treatment table for cholesterol lowering for primary prevention of coronary heart disease. Lancet. 1995 Dec 2;346(8988):1467–1471. doi: 10.1016/s0140-6736(95)92477-9. [DOI] [PubMed] [Google Scholar]
- Marang-van de Mheen P. J., Gunning-Schepers L. J. Variation between studies in reported relative risks associated with hypertension: time trends and other explanatory variables. Am J Public Health. 1998 Apr;88(4):618–622. doi: 10.2105/ajph.88.4.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilson P. W., Anderson K. M., Castelli W. P. Twelve-year incidence of coronary heart disease in middle-aged adults during the era of hypertensive therapy: the Framingham offspring study. Am J Med. 1991 Jan;90(1):11–16. doi: 10.1016/0002-9343(91)90500-w. [DOI] [PubMed] [Google Scholar]
- Yusuf H. R., Giles W. H., Croft J. B., Anda R. F., Casper M. L. Impact of multiple risk factor profiles on determining cardiovascular disease risk. Prev Med. 1998 Jan-Feb;27(1):1–9. doi: 10.1006/pmed.1997.0268. [DOI] [PubMed] [Google Scholar]