Abstract
The aim of this study was to estimate and explore the incidence of warfarin-related bleeding in a representative sample of patients in the United Kingdom. We identified 3958 patients aged 40 to 84 years, newly treated with warfarin and with no prior history of bleeding from the General Practice Research Database, and followed them for 12 months. The overall incidence of first-time, idiopathic bleeding was 15.2 per 100 patient-years of current warfarin exposure: the incidence of fatal/hospitalised and referred bleeding was 3.5 and 2.6 per 100 patient-years, respectively.
Full Text
The Full Text of this article is available as a PDF (57.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Landefeld C. S., Beyth R. J. Anticoagulant-related bleeding: clinical epidemiology, prediction, and prevention. Am J Med. 1993 Sep;95(3):315–328. doi: 10.1016/0002-9343(93)90285-w. [DOI] [PubMed] [Google Scholar]
- Lawson D. H., Sherman V., Hollowell J. The General Practice Research Database. Scientific and Ethical Advisory Group. QJM. 1998 Jun;91(6):445–452. doi: 10.1093/qjmed/91.6.445. [DOI] [PubMed] [Google Scholar]
- Levine M. N., Raskob G., Landefeld S., Kearon C. Hemorrhagic complications of anticoagulant treatment. Chest. 1998 Nov;114(5 Suppl):511S–523S. doi: 10.1378/chest.114.5_supplement.511s. [DOI] [PubMed] [Google Scholar]
- Rose P. E. Audit of anticoagulant therapy. J Clin Pathol. 1996 Jan;49(1):5–9. doi: 10.1136/jcp.49.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van der Meer F. J., Rosendaal F. R., Vandenbroucke J. P., Briët E. Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med. 1993 Jul 12;153(13):1557–1562. doi: 10.1001/archinte.153.13.1557. [DOI] [PubMed] [Google Scholar]