Skip to main content
PMC home page
Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1969 Jan;33(1):1–9.

Experimental Adenovirus Infection in Calves

P R Ide 1,2, R G Thomson 1,2, W J B Ditchfield 1,2
PMCID: PMC1319313  PMID: 4304091

Abstract

Twenty-four dairy calves ranging in age from six to 15 weeks were divided so that 10 were inoculated with bovine adenovirus serotype 1 (BA-1), eight were inoculated with bovine adenovirus serotype 3 (BA-3), and six were inoculated with control tissue culture and fluids.

Post-inoculation serum samples from most of the calves presented evidence of adenovirus infection, but none of the animals exhibited signs of respiratory or enteric disease. Histopathological examination of lung tissue was not considered to be specific for adenovirus pneumonia, but was characterized by peribronchial cuffing and slight aspiration pneumonia. BA-1 was not isolated from any of the inoculated calves, and BA-3 was only recovered from the feces of two animals.

Reasons for the discrepancy between these results and those of other workers are considered, and the etiology of peribronchial cuffing is briefly discussed.

Full text

PDF
1

Images in this article

6Fig. 2.
on p.6
6Fig. 3.
on p.6
7Fig. 4.
on p.7
7Fig. 5.
on p.7
7Fig. 6.
on p.7
8Fig. 7.
on p.8

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALDASY P., CSONTOS L., BARTHA A. PNEUMO-ENTERITIS IN CALVES CAUSED BY ADENOVIRUSES. Acta Vet Acad Sci Hung. 1965;15:167–175. [PubMed] [Google Scholar]
  2. ANDREWES C. H., NIVEN J. S. F. A virus from cotton-rats: its relation to grey lung virus. Br J Exp Pathol. 1950 Dec;31(6):773–778. [PMC free article] [PubMed] [Google Scholar]
  3. BOYER G. S., LEUCHTENBERGER C., GINSBERG H. S. Cytological and cytochemical studies of HeLa cells infected with adeno-viruses. J Exp Med. 1957 Mar 1;105(3):195–216. doi: 10.1084/jem.105.3.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bartha A., Aldásy P. Further two serotypes of bovine adenoviruses (serotype 4 and 5). Acta Vet Acad Sci Hung. 1966;16(1):107–108. [PubMed] [Google Scholar]
  5. DUNGWORTH D. L., CORDY D. R. The pathogenesis of ovine pneumonia. II. Isolation of virus from faeces; comparison of pneumonia caused by faecal, enzootic abortion and pneumonitis viruses. J Comp Pathol. 1962 Jan;72:71–79. [PubMed] [Google Scholar]
  6. Darbyshire J. H., Dawson P. S., Lamont P. H., Ostler D. C., Pereira H. G. A new adenovirus serotype of bovine origin. J Comp Pathol. 1965 Jul;75(3):327–330. doi: 10.1016/0021-9975(65)90038-1. [DOI] [PubMed] [Google Scholar]
  7. Darbyshire J. H., Jennings A. R., Dawson P. S., Lamont P. H., Omar A. R. The pathogenesis and pathology of infection in calves with a strain of bovine adenovirus type 3. Res Vet Sci. 1966 Jan;7(1):81–93. [PubMed] [Google Scholar]
  8. GIRARDI A. J. The use of fluorocarbon for "unmasking" polyoma virus hemagglutinin. Virology. 1959 Nov;9:488–489. doi: 10.1016/0042-6822(59)90141-2. [DOI] [PubMed] [Google Scholar]
  9. GROSS P., WESTRICK M. L., McNERNEY J. M. The pulmonary response to certain chronic irritants: an experimental study on rats and guinea pigs. Arch Pathol. 1959 Sep;68:252–261. [PubMed] [Google Scholar]
  10. Harbourne J. F. Survey of bovine respiratory diseases with special reference to the serological examination of paired serum samples. Vet Rec. 1966 May 28;78(22):749–752. doi: 10.1136/vr.78.22.749. [DOI] [PubMed] [Google Scholar]
  11. INNES J. R., MCADAMS A. J., YEVICH P. Pulmonary disease in rats; a survey with comments on chronic murine pneumonia. Am J Pathol. 1956 Jan-Feb;32(1):141–159. [PMC free article] [PubMed] [Google Scholar]
  12. KLEIN M., EARLEY E., ZELLAT J. Isolation from cattle of a virus related to human adenovirus. Proc Soc Exp Biol Med. 1959 Oct;102:1–4. doi: 10.3181/00379727-102-25123. [DOI] [PubMed] [Google Scholar]
  13. KLEIN M. The relationship of two bovine adenoviruses to human adenoviruses. Ann N Y Acad Sci. 1962 Nov 30;101:493–497. doi: 10.1111/j.1749-6632.1962.tb18890.x. [DOI] [PubMed] [Google Scholar]
  14. KLEIN M., ZELLAT J., MICHAELSON T. C. A new bovine adenovirus related to human adenovirus. Proc Soc Exp Biol Med. 1960 Nov;105:340–342. doi: 10.3181/00379727-105-26104. [DOI] [PubMed] [Google Scholar]
  15. KUSANO N., KAWAI K., AOYAMA Y. Intranuclear inclusion body in fatal infantile pneumonia due to adenovirus. Jpn J Exp Med. 1958 Aug;28(4):301–304. [PubMed] [Google Scholar]
  16. Maré C. J., Switzer W. P. Virus pneumonia of pigs: propagation and characterization of a causative agent. Am J Vet Res. 1966 Nov;27(121):1687–1693. [PubMed] [Google Scholar]
  17. Mohanty S. B., Lillie M. G. Experimental infection of calves with a bovine adenovirus. Proc Soc Exp Biol Med. 1965 Dec;120(3):679–682. doi: 10.3181/00379727-120-30623. [DOI] [PubMed] [Google Scholar]
  18. Piercy S. E. Immunologic principles in active immunity. J Am Vet Med Assoc. 1966 Sep 1;149(5):648–657. [PubMed] [Google Scholar]
  19. RAFAJKO R. R. PRODUCTION AND STANDARDIZATION OF ADENOVIRUS TYPES 1 TO 18 REFERENCE ANTISERA. Am J Hyg. 1964 May;79:310–319. doi: 10.1093/oxfordjournals.aje.a120385. [DOI] [PubMed] [Google Scholar]
  20. ROWE W. P., HUEBNER R. J., GILMORE L. K., PARROTT R. H., WARD T. G. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med. 1953 Dec;84(3):570–573. doi: 10.3181/00379727-84-20714. [DOI] [PubMed] [Google Scholar]
  21. Sohier R., Chardonnet Y., Prunieras M. Adenoviruses. Status of current knowledge. Prog Med Virol. 1965;7:253–325. [PubMed] [Google Scholar]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES