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. 1970 Oct;34(4):312–319.

Serum Biochemical and Hematological Parameters of Sinclair(S-1) Miniature Sows During Gestation and Lactation

M E Tumbleson 1,2,3, Marlyn F Burks 1,2,3, Marilyn P Spate 1,2,3, D P Hutcheson 1,2,3, C C Middleton 1,2,3
PMCID: PMC1319472  PMID: 4249094

Abstract

Venous blood samples were collected from 29 Sinclair(S-1) miniature sows at 14, ten, six and two weeks prior to parturition and two, four and six weeks postpartum to determine the effect of pregnancy and lactation upon 19 serum biochemical and 12 hematological parameters. During gestation, the levels of serum cholesterol, blood urea nitrogen and alpha1-globulin, as well as packed cell volume and hemoglobin concentration, decreased; whereas, the level of serum beta-globulin increased. During lactation, the concentrations of serum glucose, total protein, albumin, beta-globulin, calcium, sodium and hemoglobin, as well as packed cell volume, decreased; whereas, the concentration of serum cholesterol and the activity of serum alkaline phosphatase increased.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen J. R., Ahlgren S. A. A comparative study of the hematologic changes in pregnancy in the Macaca mulatta monkey and the human female. Am J Obstet Gynecol. 1968 Apr;100(7):894–903. doi: 10.1016/s0002-9378(15)33745-5. [DOI] [PubMed] [Google Scholar]
  2. Allen J. R., Siegfried L. M. Hematologic alterations in pregnant rheusus monkeys. Lab Anim Care. 1966 Dec;16(6):465–471. [PubMed] [Google Scholar]
  3. BOND C. F. Blood volume changes in the lactating rat. Endocrinology. 1958 Sep;63(3):285–289. doi: 10.1210/endo-63-3-285. [DOI] [PubMed] [Google Scholar]
  4. Boyd E. M. THE LIPEMIA OF PREGNANCY. J Clin Invest. 1934 Mar;13(2):347–363. doi: 10.1172/JCI100590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bustad L. K. Pigs in the laboratory. Sci Am. 1966 Jun;214(6):94–100. doi: 10.1038/scientificamerican0666-94. [DOI] [PubMed] [Google Scholar]
  6. DARBY W. J., McGANITY W. J., MARTIN M. P., BRIDGFORT E., DENSEN P. M., KASER M. M., OGLE P. J., NEWBILL J. A., STOCKELL A., FERGUSON M. E. The Vanderbilt cooperative study of maternal and infant nutrition. IV. Dietary, laboratory and physical findings in 2,129 delivered pregnancies. J Nutr. 1953 Dec 10;51(4):565–597. doi: 10.1093/jn/51.4.565. [DOI] [PubMed] [Google Scholar]
  7. DE ALVAREZ R. R., GAISER D. F., SIMKINS D. M., SMITH E. K., BRATVOLD G. E. Serial studies of serum lipids in normal human pregnancy. Am J Obstet Gynecol. 1959 Apr;77(4):743–759. [PubMed] [Google Scholar]
  8. Donovan J. C., Lund C. J., Hicks E. L. Effect of lactation on blood volume in the human female. Am J Obstet Gynecol. 1965 Oct 15;93(4):588–589. doi: 10.1016/0002-9378(65)90521-1. [DOI] [PubMed] [Google Scholar]
  9. EARL F. L., TEGERIS A. S., WHITMORE G. E., MORISON R., FITZHUGH O. G. THE USE OF SWINE IN DRUG TOXICITY STUDIES. Ann N Y Acad Sci. 1964 Apr 24;111:671–688. doi: 10.1111/j.1749-6632.1964.tb53136.x. [DOI] [PubMed] [Google Scholar]
  10. FILLIOS L. C., KAPLAN R., MARTIN R. S., STARE F. J. Some aspects of the gonadal regulation of cholesterol metabolism. Am J Physiol. 1958 Apr;193(1):47–51. doi: 10.1152/ajplegacy.1958.193.1.47. [DOI] [PubMed] [Google Scholar]
  11. Fabian E., Stork A., Kucerová L., Sponarová J. Plasma levels of free fatty acids, lipoprotein lipase, and postheparin esterase in pregnancy. Am J Obstet Gynecol. 1968 Apr;100(7):904–907. [PubMed] [Google Scholar]
  12. Fell B. F., Mackie W. S., Campbell R. M., Regoeczi E. Quantitative changes occurring in the serum proteins during lactation in the ewe. Res Vet Sci. 1968 Nov;9(6):563–572. [PubMed] [Google Scholar]
  13. Green J. G. Serum cholesterol changes in pregnancy. Am J Obstet Gynecol. 1966 Jun 1;95(3):387–393. doi: 10.1016/0002-9378(66)90123-2. [DOI] [PubMed] [Google Scholar]
  14. Kayden H. J., Dancis J., Money W. L. Transfer of lipids across the guinea pig placenta. Am J Obstet Gynecol. 1969 Jun 15;104(4):564–572. doi: 10.1016/s0002-9378(16)34248-x. [DOI] [PubMed] [Google Scholar]
  15. Kerr G. R. The free amino acids of serum during development of Macaca mulatta. II. During pregnancy and fetal life. Pediatr Res. 1968 Nov;2(6):493–500. doi: 10.1203/00006450-196811000-00007. [DOI] [PubMed] [Google Scholar]
  16. Kirsch R. E., Saunders S. J., Brock J. F. Animal models and human protein-calorie malnutrition. Am J Clin Nutr. 1968 Nov;21(11):1225–1228. doi: 10.1093/ajcn/21.11.1225. [DOI] [PubMed] [Google Scholar]
  17. Kuhlbäck B., Widholm O. Plasma creatinine in normal pregnancy. Scand J Clin Lab Invest. 1966;18(6):654–656. doi: 10.3109/00365516609049049. [DOI] [PubMed] [Google Scholar]
  18. LOW J. A., JOHNSTON E. E., MCBRIDE R. L. BLOOD VOLUME ADJUSTMENTS IN THE NORMAL OBSTETRIC PATIENT WITH PARTICULAR REFERENCE TO THE THIRD TRIMESTER OF PREGNANCY. Am J Obstet Gynecol. 1965 Feb 1;91:356–363. doi: 10.1016/0002-9378(65)90250-4. [DOI] [PubMed] [Google Scholar]
  19. Lucas E. W., Holden P. J., Speer V. C., Hays V. W. Effect of protein level during pregnancy and lactation on plasma amino acid profile of swine. J Anim Sci. 1969 Sep;29(3):429–432. doi: 10.2527/jas1969.293429x. [DOI] [PubMed] [Google Scholar]
  20. MILLER E. R., ULLREY D. E., ACKERMANN I., SCHMIDT D. A., LUECKE R. W., HOEFER J. A. Swine hematology from birth to maturity. II. Erythrocyte population, size and hemoglobin concentration. J Anim Sci. 1961 Nov;20:890–897. doi: 10.2527/jas1961.204890x. [DOI] [PubMed] [Google Scholar]
  21. MULLICK S., BAGGA O. P., DUMULLICK V. SERUM LIPID STUDIES IN PREGNANCY. Am J Obstet Gynecol. 1964 Jul 15;89:766–770. doi: 10.1016/0002-9378(64)90180-2. [DOI] [PubMed] [Google Scholar]
  22. OLIVER M. F., BOYD G. S. Plasma lipid and serum lipoprotein patterns during pregnancy and puerperium. Clin Sci. 1955 Feb;14(1):15–23. [PubMed] [Google Scholar]
  23. RATH C. E., CATON W. Hematological changes and iron metabolism of normal pregnancy. Surg Gynecol Obstet. 1950 Mar;90(3):320–326. [PubMed] [Google Scholar]
  24. REYNOLDS M. Measurement of bovine plasma and blood volume during pregnancy and lactation. Am J Physiol. 1953 Oct;175(1):118–122. doi: 10.1152/ajplegacy.1953.175.1.118. [DOI] [PubMed] [Google Scholar]
  25. ROMINGER C. J. BLOOD VOLUME STUDIES IN NORMAL PREGNANCY, TOXEMIA AND GYNECOLOGIC PATIENTS. Am Surg. 1964 Jun;30:357–363. [PubMed] [Google Scholar]
  26. Spicer E. J., Oxnard C. E. Some haematological changes during pregnancy in the rhesus monkey (Macaca mulatta). Folia Primatol (Basel) 1967;6(3):236–242. doi: 10.1159/000155081. [DOI] [PubMed] [Google Scholar]
  27. TYSOE F. W., LOWENSTEIN L., SIMON F. Blood volume and hematologic studies in pregnancy and the puerperium. Am J Obstet Gynecol. 1950 Dec;60(6):1187–1205. doi: 10.1016/0002-9378(50)90001-9. [DOI] [PubMed] [Google Scholar]
  28. Tietz W. J., Benjamin M. M., Angleton G. M. Anemia and cholesterolemia during estrus and pregnancy in the Beagle. Am J Physiol. 1967 Mar;212(3):693–697. doi: 10.1152/ajplegacy.1967.212.3.693. [DOI] [PubMed] [Google Scholar]
  29. Tumbleson M. E., Dommert A. R., Middleton C. C. Techniques for handling miniature swine for laboratory procedures. Lab Anim Care. 1968 Oct;18(5):584–587. [PubMed] [Google Scholar]
  30. Tumbleson M. E., Tinsley O. W., Corwin L. A., Jr, Flatt R. E., Flynn M. A. Undernutrition in young miniature swine. J Nutr. 1969 Dec;99(4):505–518. doi: 10.1093/jn/99.4.505. [DOI] [PubMed] [Google Scholar]
  31. VAN ZYL A. Serum protein-bound iodine and serum lipid changes in the baboon (Papio ursinus). II. During pregnancy, lactation and abortion. J Endocrinol. 1957 Jan;14(4):317–324. doi: 10.1677/joe.0.0140317. [DOI] [PubMed] [Google Scholar]
  32. WEAVER M. E., MCKEAN C. F. MINIATURE SWINE AS LABORATORY ANIMALS. Lab Anim Care. 1965 Feb;15:49–56. [PubMed] [Google Scholar]
  33. Wolf R. C., Bowman R. E. Adrenocortical function during pregnancy in the rhesus monkey. Proc Soc Exp Biol Med. 1966 Mar;121(3):986–988. doi: 10.3181/00379727-121-30943. [DOI] [PubMed] [Google Scholar]
  34. Wolf R. C., Temte L., Meyer R. K. Plasma cholesterol in pregnancy rhesus monkeys. Proc Soc Exp Biol Med. 1967 Aug-Sep;125(4):1230–1231. doi: 10.3181/00379727-125-32321. [DOI] [PubMed] [Google Scholar]

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