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. 1970 Apr;34(2):148–154.

Treatment of Edema Disease of Swine

I C Pan 1, H C Chen 1, R L Morter 1
PMCID: PMC1319521  PMID: 4392719

Abstract

Antihistamine (Allermin) was used sucessfully in the treatment of naturally occurring edema disease of swine under the field and laboratory conditions. A high recovery rate (88.8%) was obtained in the group of pigs with mild clinical signs. The intravenous route of Allermin administration had definite beneficial value. The release of histamine induced by circulating immune-complexes may be responsible for the clinical signs characteristic of edema disease.

Three pigs that recovered clinically following the Allermin treatment were examined histologically. Fibrinoid persisted in the vascular walls at least 30 days after the initiation of the treatment. The fibrinoid vasculitis, generalized eosinophilia at the tissue level, and favorable response of pigs to antihistamine treatment suggest that edema disease may be caused by allergy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COCHRANE C. G., WEIGLE W. O. The cutaneous reaction to soluble antigen-antibody complexes; a comparison with the Arthus phenomenon. J Exp Med. 1958 Nov 1;108(5):591–604. doi: 10.1084/jem.108.5.591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GREGORY D. W. Experimental edema disease (hemolytic Escherichia coli toxemia) in pigs and in mice. Am J Vet Res. 1960 Jan;21:88–94. [PubMed] [Google Scholar]
  3. Harding J. D. A cerebrospinal angiopathy in pigs. Pathol Vet. 1966;3(1):83–88. doi: 10.1177/030098586600300105. [DOI] [PubMed] [Google Scholar]
  4. ISHIZAKA K., ISHIZAKA T., CAMPBELL D. H. Biologic activity of soluble antigen-antibody complexes. III. J Immunol. 1959 Aug;83:105–115. [PubMed] [Google Scholar]
  5. JONES J. E., SMITH H. W. THE EFFECT OF INTRAVENOUS INJECTION OF EXTRACTS OF ESCHERICHIA COLI IN PIGS AND MICE. J Pathol Bacteriol. 1964 Jan;87:113–122. doi: 10.1002/path.1700870116. [DOI] [PubMed] [Google Scholar]
  6. Kurtz H. J., Bergeland M. E., Barnes D. M. Pathologic changes in edema disease of swine. Am J Vet Res. 1969 May;30(5):791–806. [PubMed] [Google Scholar]
  7. Nielsen N. O., Sautter J. H., Stevens J. B., Hart B. L. Attempts to produce edema disease of swine experimentally with hemolytic Escherichia coli. Am J Vet Res. 1965 Jul;26(113):928–931. [PubMed] [Google Scholar]
  8. Schofield F. W., Robertson A. Oedema Disease (Entero-Toxaemia) in Swine - I. Experiments Designed To Reproduce The Disease. Can J Comp Med Vet Sci. 1955 Aug;19(8):240–242. [PMC free article] [PubMed] [Google Scholar]
  9. Schofield F. W., Schroder J. D. Some Important Aspects Of Oedema Disease In Swine (Entero-Toxemia). Can J Comp Med Vet Sci. 1954 Jan;18(1):24–28. [PMC free article] [PubMed] [Google Scholar]
  10. Schulz L. C., Reichel K. Zur Oedembildung bei der Colienterotoxaemie des Schweines und zur Pathogenese zentralnervöser Symptome. Dtsch Tierarztl Wochenschr. 1964 Oct 15;71(20):552–556. [PubMed] [Google Scholar]
  11. THOMLINSON J. R., BUXTON A. Anaphylaxis in pigs and its relationship to the pathogenesis of oedema disease and gastro-enteritis associated with Escherichia coli. Immunology. 1963 Mar;6:126–139. [PMC free article] [PubMed] [Google Scholar]

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