Abstract
Erythrocyte labeling by random and cohort techniques was used to study erythrocyte survival in normal chickens and in chickens infected with Plasmodium gallinaceum. White Leghorn chickens, eight weeks of age, were used in this series of experiments.
In chickens given P. gallinaceum on the day following erythrocyte labeling there was destruction of labeled erythrocytes at a much more rapid rate than would result from normal ageing processes. Chickens given P. gallinaceum 12, 18 and 21 days after the labeling of the erythrocytes failed to show any greater destruction of the labeled red cells beyond that resulting from normal senescence. This result indicates that erythrocytes over 12 days of age are not destroyed by P. gallinaceum.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COHEN J. A., WARRINGA M. G. The fate of P32 labelled diisopropylfluorophosphonate in the human body and its use as a labelling agent in the study of the turnover of blood plasma and red cells. J Clin Invest. 1954 Mar;33(3):459–467. doi: 10.1172/JCI102917. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conrad M. E. Pathophysiology of malaria. Hematologic observations in human and animal studies. Ann Intern Med. 1969 Jan;70(1):134–141. doi: 10.7326/0003-4819-70-1-134. [DOI] [PubMed] [Google Scholar]
- Criswell B. S., Butler W. T., Rossen R. D., Knight V. Murine malaria: the role of humoral factors and macrophages in destruction of parasitized erythrocytes. J Immunol. 1971 Jul;107(1):212–221. [PubMed] [Google Scholar]
- HUFF C. G. Organ and tissue distribution of the exoerythrocytic stages of various avian malarial parasites. Exp Parasitol. 1957 Mar;6(2):143–162. doi: 10.1016/0014-4894(57)90012-7. [DOI] [PubMed] [Google Scholar]
- Kreier J. P., Leste J. Relationship of parasitemia to erythrocyte destruction in Plasmodium berghei infected rats. Exp Parasitol. 1967 Aug;21(1):78–83. doi: 10.1016/0014-4894(67)90070-7. [DOI] [PubMed] [Google Scholar]
- Kreier J. P. Mechanisms of erythrocyte destruction in chickens infected with Plasmodium gallinaceum. Mil Med. 1969 Sep;134(10):1203–1219. [PubMed] [Google Scholar]
- Mathias A. P., Ridge D., Trezona N. S. A study of nucleated erythrocytes by density-gradient centrifugation in a zonal rotor. Biochem J. 1969 Feb;111(4):583–591. doi: 10.1042/bj1110583. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PRANKERD T. A. Red-cell structure and metabolism in haemolytic anaemia. Br Med Bull. 1959 Jan;15(1):54–58. doi: 10.1093/oxfordjournals.bmb.a069716. [DOI] [PubMed] [Google Scholar]
- Swann A. I., Kreier J. P. Plasmodium gallinaceum: mechanisms of anemia in infected chickens. Exp Parasitol. 1973 Feb;33(1):79–88. doi: 10.1016/0014-4894(73)90011-8. [DOI] [PubMed] [Google Scholar]
- ZUCKERMAN A. AUTOIMMUNIZATION AND OTHER TYPES OF INDIRECT DAMAGE TO HOST CELLS AS FACTORS IN CERTAIN PROTOZOAN DISEASES. Exp Parasitol. 1964 Apr;15:138–183. doi: 10.1016/0014-4894(64)90014-1. [DOI] [PubMed] [Google Scholar]