Abstract
The coronavirus disease 2019 pandemic profoundly disrupted global health systems, exacerbating preexisting inequalities in access to and quality of care. Disparities in service accessibility, continuity, coordination, and comprehensiveness highlight the need for a multidimensional, data-driven approach to healthcare evaluation. We conducted a retrospective analysis using 52,490 responses from the 2021 Global Burden of Disease COVID-19 Health Service Disruption Survey. We developed a 4-dimensional evaluation framework aligned with World Health Organization principles for people-centered care. Following variable selection, standardized preprocessing, and manual labeling, we trained and assessed 6 machine learning (ML) algorithms. We further optimized the 2 best-performing models – support vector machine (SVM) and random forest (RF) – using interpolation-based data augmentation, cross-validated hyperparameter tuning, and particle swarm optimization. SVM showed the highest baseline performance (accuracy 0.93), whereas RF achieved competitive macro-F1 scores. Interpolation-based data augmentation improved the generalizability of the SVM model, increasing its accuracy to 0.96. The RF model benefited most from particle swarm optimization-based hyperparameter optimization. Model predictions revealed persistent inequalities in healthcare service quality: respondents with lower income, lower educational attainment, and rural residence were disproportionately classified as receiving lower-quality services, whereas urban residence and higher income were associated with higher-quality care. Our scalable ML framework successfully assessed healthcare service quality during the pandemic, with optimized SVM and RF models demonstrating robust performance on high-dimensional, imbalanced survey data. Post-pandemic recovery strategies must prioritize socioeconomically disadvantaged populations. Furthermore, integrating ML tools can enhance real-time quality monitoring within health systems.
Keywords: COVID-19, Global Burden of Disease, healthcare service quality, machine learning, random forest, support vector machine
1. Introduction
The Global Burden of Disease (GBD) program provides systematic estimates of health loss across 204 countries and territories and serves as an important foundation for evidence-based policymaking.[1] The coronavirus disease 2019 (COVID-19) pandemic placed health systems under exceptional pressure worldwide, disrupting essential services, delaying care, and creating persistent challenges in accessibility, continuity, coordination, and comprehensiveness of care.[2–5] These disruptions were consistently documented in global monitoring reports and pulse surveys conducted by the World Health Organization (WHO).[2–5] The quality of health services is conceptually informed by the structure-process-outcome model of Donabedian and by the core principles of primary care described in analyses from the European Observatory.[6] Coordination and continuity of care, which are central features of people-centered health systems, have been repeatedly associated with better outcomes and lower levels of inequality.[7] WHO frameworks, including integrated people-centered health services (IPCHS) and integrated care for older people (ICOPE), further emphasize the need for service delivery models that ensure accessibility, continuity, comprehensiveness, and responsiveness to population needs.[8,9]
High-quality health systems are essential for achieving universal health coverage (UHC), as highlighted by the Lancet Commission on High-Quality Health Systems and other global monitoring initiatives.[10,11] In this context, progress toward UHC depends not only on service availability but also on equitable access and effective coverage, both of which remain unevenly distributed across socioeconomic groups.[11–13] Social determinants of health, including income, education, and geographic location, continue to shape disparities in service use and service quality. These inequities became more visible during the pandemic and underscored the importance of monitoring service restoration.[14–22] At the same time, machine learning (ML) has become a useful approach for analyzing high-dimensional health data and developing scalable evaluation frameworks.[23–25] Although ML has been widely used for diagnostic prediction and risk stratification, its application to system-level assessment of service quality remains limited, particularly in analyses based on globally representative datasets such as the GBD COVID-19 Health Service Disruption Survey.[26] Previous studies using GBD data have mainly focused on disease burden, forecasting models, or effective coverage indices for UHC monitoring.[1,11,27] Multidimensional ML-based evaluation of service disruption and recovery quality remains scarce.
The objective of this study was to build and validate an ML pipeline for the assessment of healthcare service quality across 4 dimensions: accessibility, continuity, coordination, and comprehensiveness, using GBD 2021 survey data. A further objective was to identify disparities in service quality across income groups, regions, and demographic subgroups, thereby providing evidence to support equitable resource allocation and post-pandemic recovery planning.
2. Methods
2.1. Study design and data source
This study was a retrospective secondary analysis of data from the GBD 2021 COVID-19 Health Service Disruption Survey, a global dataset compiled by the Institute for Health Metrics and Evaluation.[26] The survey included 52,490 responses from populations across different regions and income settings and recorded changes in health service use, reasons for seeking care, medication needs, and chronic disease management during the pandemic. These data complement the WHO global pulse surveys, which also documented widespread disruption to essential health services.[2–5] All records were anonymized and publicly available; therefore, ethical approval was not required.
2.2. Four-dimension evaluation framework
Guided by WHO frameworks on IPCHS and UHC monitoring, we developed a 4-dimension analytical framework comprising accessibility, continuity, coordination, and comprehensiveness[8,11] (Table 1). These dimensions parallel foundational concepts in health services research, including the Donabedian model and primary care attributes identified in the European Observatory’s analysis of health systems.[6,7] Accessibility was assessed using indicators of service use before and after the pandemic, care setting, reasons for visits, service coverage radius, and proxy measures of waiting time. Continuity reflected changes in health status and ongoing care needs, in line with earlier WHO ICOPE recommendations.[9] Coordination captured transitions across levels of care and the integration of care networks, which have been associated with improved patient experience and better outcomes.[7] Comprehensiveness included medication needs, treatment indications, and missed doses, which are closely related to continuity in chronic disease management.[14–19] The Service Restoration Index was included as an additional proxy for the extent of recovery from pandemic disruptions, consistent with WHO guidance on maintaining essential services.[2–5]
Table 1.
Variables retained for the 4-dimension framework after screening.
| Column name | Meaning |
|---|---|
| user_id | User account identifier |
| gp_pre/post_provider_need | Whether the respondent had healthcare service needs before/after the pandemic |
| gp_pre/post_provider_condition | Reasons for needing healthcare services before/after the pandemic |
| gp_pre/post_provider_visit | Whether the respondent received needed healthcare services before/after the pandemic |
| gp_pre/post_provider_where | Level or type of healthcare provider visited before/after the pandemic |
| gp_pre/post_provider_why | Reasons for not receiving needed healthcare services before/after the pandemic |
| gp_medication | Medication treatment needs |
| gp_medication_condition | Reasons for requiring medication treatment |
| gp_pre/post_miss_dose | Whether the respondent missed medication doses before/after the pandemic |
| gender/age/educate/labor | Demographic characteristics (gender, age, educational attainment, employment status) |
| Overall evaluation | Overall evaluation of healthcare service quality |
2.3. Data selection and preprocessing
Variables irrelevant to the 4 dimensions were removed, and inconsistent categorical levels were harmonized. Missing values were handled using structured imputation strategies informed by methodological guidance from van Buuren and Little and Rubin.[28,29] Numerical variables were assigned constant placeholders, whereas categorical variables were assigned a “missing” category before 1-hot encoding. Observations without meaningful information related to healthcare or care needs were removed. Feature selection followed widely used criteria described by Chandrashekar et al.[30] All preprocessing steps were implemented in Python using Scikit-learn[31] (Fig. 1).
Figure 1.
Data processing workflow.
2.4. Manual annotation
To generate ground-truth labels for supervised learning, trained annotators classified the quality of healthcare service received by each respondent as “high,” “moderate,” or “low.” Labeling criteria were derived from WHO quality-of-care standards and UHC monitoring constructs.[8,9,11,12] Approximately 15% of the sample was double-coded, and inter-rater reliability exceeded 90%. Cohen kappa values met the thresholds for “substantial” to “almost perfect” agreement according to published methodological guidelines.[32,33] Disagreements were resolved through consensus meetings to ensure labeling consistency.
2.5. Model development and evaluation
Six algorithms commonly used for structured health survey datasets were trained and evaluated: gradient boosting, support vector machine (SVM), random forest (RF), k-nearest neighbors, linear discriminant analysis, and a shallow neural network. The use of these algorithms is supported by previous applications of ML in health research, including predictive analytics and system-level modeling.[23–25,34–37]
Data were split into training (70%) and testing (30%) sets. Model performance was evaluated using accuracy, macro-precision, macro-recall, and macro-F1, which provide a balanced assessment in the presence of class imbalance.[38] Confusion matrices were used to examine category-specific misclassifications.
2.6. Model optimization
The 2 best-performing baseline models, SVM and RF, were further optimized through a structured 3-stage procedure. First, interpolation-based augmentation was applied to underrepresented classes using principles similar to those of the Synthetic Minority Over-sampling Technique synthetic sampling framework.[39,40] This step was intended to reduce class imbalance and improve generalizability. Second, hyperparameter tuning was conducted using grid search and random search, both of which have been shown to perform better than manual tuning in high-dimensional settings.[34,35] For SVM, the parameter space included kernel type, C, and γ. For RF, the parameter space included n_estimators, max_depth, and min_samples_split. Third, particle swarm optimization (PSO) was used to explore non-convex parameter spaces. PSO is a population-based metaheuristic that has been widely applied in ML optimization.[41] The optimization process followed canonical velocity-position update rules to improve the efficiency of global search (Fig. 2). Performance metrics followed the scoring convention of Scikit-learn, in which minimization objectives are represented by negated values; these were converted to positive accuracy values for interpretation.[31]
Figure 2.
PSO principle and parameter update scheme. PSO = particle swarm optimization.
2.7. Ethical considerations
All data were deidentified and publicly available through the Institute for Health Metrics and Evaluation and the WHO repositories[26]. The study followed WHO ethical principles for secondary analysis of health data. No human subjects or animals were directly involved, and institutional review board approval was not required.[2–5]
3. Results
3.1. Baseline model comparison
Among the 6 algorithms evaluated – gradient boosting, SVM, RF, k-nearest neighbors, linear discriminant analysis, and a shallow neural network – SVM showed the best overall baseline performance (Table 2). This is consistent with previous studies reporting that SVM performs well on high-dimensional structured data because of its margin-maximizing properties.[23,42]
Table 2.
Algorithms evaluated and key characteristics with performance summary.
| Algorithm | Applicable scenarios | Advantages | Limitations |
|---|---|---|---|
| Gradient boosting | Structured/tabular data; various data types | High performance; capable of handling diverse data types | Complex hyperparameter tuning; higher model complexity |
| Support vector machine (SVM) | Small-sample, high-dimensional data | Strong generalization ability; suitable for limited datasets | Sensitive to parameter settings; kernel selection can be difficult |
| Random forest (RF) | High-dimensional data; datasets with many features | Robust performance; handles many features effectively | Longer training time; limited interpretability |
| k-nearest neighbors (KNN) | Small-scale, low-dimensional data | Simple and intuitive; easy to implement | Low computational efficiency; high memory consumption |
| Linear discriminant analysis (LDA) | Linearly separable data; small/medium-scale datasets | Computationally simple; effective for linear problems | Strong distributional assumptions; low flexibility |
| Neural network | Large-scale datasets; complex pattern recognition | Strong nonlinear modeling ability; highly adaptable | Difficult to train; prone to overfitting |
The SVM achieved an accuracy of 0.93 and a weighted F1-score of 0.93. RF also performed well, with a macro-F1 score of 0.91, in line with earlier reports that ensemble methods are effective for tabular classification tasks.[43] Gradient boosting also achieved good accuracy, although its performance varied more across folds. This may reflect sensitivity to heterogeneous categorical encoding and class imbalance, which are known challenges in this type of dataset[36,38] (Fig. 3).
Figure 3.
Comparison of baseline models (accuracy, precision/recall/F1).
3.2. Optimization outcomes
3.2.1. Support vector machine
Interpolation-based augmentation improved the generalization of SVM. Synthetic minority sampling, using a strategy similar to Synthetic Minority Over-sampling Technique, improved class balance and produced the highest test accuracy of 0.9644.[39,40] This is consistent with previous studies showing that resampling can significantly improve classifier robustness in imbalanced datasets.[38]
Additional hyperparameter tuning with grid search and random search led to only small additional gains. This agrees with previous methodological studies suggesting that SVM performance is mainly determined by kernel selection and margin-related parameters.[34,35] PSO produced little further improvement, possibly because the SVM parameter space is less dependent on broad global exploration than that of tree-based models[41] (Fig. 4).
Figure 4.
SVM optimization results (augmentation vs grid vs PSO). PSO = particle swarm optimization, SVM = support vector machine.
3.2.2. Random forest
For RF, PSO produced the largest performance improvement, outperforming both grid search and random search. Its population-based search may better capture complex interactions among parameters such as tree depth, split thresholds, and the number of estimators, all of which strongly affect RF performance.[41] RF accuracy improved to 0.931 after optimization.[31]
Data augmentation also improved RF performance, but the gain was smaller than that achieved through PSO-based hyperparameter optimization. This is consistent with previous work suggesting that ensemble models often benefit more from structural parameter tuning than from synthetic resampling alone[36,37] (Fig. 5).
Figure 5.
RF optimization results (grid vs PSO). PSO = particle swarm optimization, RF = random forest.
3.3. Disparities in predicted service quality
Model predictions showed clear socioeconomic disparities in estimated healthcare service quality. Respondents in lower-income groups were more often classified as receiving “low” quality services, whereas those in higher-income and urban groups were more frequently classified as receiving “high” quality care. These findings are consistent with the WHO global UHC monitoring report and previous studies on the social determinants of health[1,11,27] (Fig. 6).
Figure 6.
Distribution of predicted service levels by income group.
Rural residents exhibited significantly lower accessibility and continuity scores, consistent with long-standing evidence showing barriers faced by rural populations in low- and middle-income countries.[14–16,18,19] In contrast, urban residents and respondents with higher education demonstrated more stable continuity and better coordination patterns, reflecting stronger integration between primary and referral care services.[6,7]
Age-related differences were also observed. Older adults had lower continuity and coordination scores, which may be related to deferred care, multimorbidity, and disruptions in chronic disease management during the pandemic.[9,14–18] These findings are also consistent with the WHO ICOPE framework, which highlights the vulnerability of older populations during health system shocks.
Regional disparities also followed global income patterns, in agreement with findings from the GBD Healthcare Access and Quality Index and UHC effective coverage analyses.[27] Higher-income regions displayed stronger recovery of health service delivery, while lower-income regions continued to experience gaps in access and comprehensiveness (Fig. 7).
Figure 7.
Regional and socioeconomic correlates of predicted service quality.
4. Discussion
This study presents a scalable ML framework for the multidimensional assessment of healthcare service quality during the COVID-19 pandemic. By integrating WHO people-centered care domains and leveraging a large global dataset, the framework quantifies accessibility, continuity, coordination, and comprehensiveness across diverse population groups. Our findings yield 2 main insights related to methodological performance and health system disparities.
First, the results indicate that both model selection and optimization strategy substantially influence predictive performance. Data augmentation markedly improved SVM performance by reducing class imbalance, a well-recognized challenge in health survey datasets.[38–40] The optimized SVM model achieved an accuracy of 0.9644, supporting previous evidence that SVM maintains strong generalizability in high-dimensional settings.[23,42] We speculate that the robust performance of the SVM model in this context is due to its ability to define clear decision boundaries even when survey responses present sparse or overlapping feature spaces.
By contrast, RF benefited most from PSO-based hyperparameter optimization. PSO enabled more effective exploration of non-convex parameter spaces, improving RF accuracy beyond that achieved with conventional grid or random search.[41] This pattern is consistent with comparative ML studies showing that tree-based ensemble methods are highly responsive to structural hyperparameter tuning, whereas margin-based models such as SVM rely more on data balancing and kernel selection.[36,37]
Taken together, these findings reinforce that no single optimization strategy is universally superior; rather, optimal performance depends on the underlying model architecture. This observation is consistent with the broader ML literature, which supports tailored, model-specific optimization strategies to maximize predictive performance.[23–25,34–37]
Second, our results underscore the persistence of socioeconomic inequities in healthcare service quality during pandemic recovery. Respondents with low income, low educational attainment, and rural residence were consistently classified into lower service-quality categories, reflecting long-standing evidence on social determinants of health and resource disparities.[12,13] These gradients also reflect patterns reported in WHO UHC monitoring and GBD effective coverage analyses, where poorer regions exhibit systematically lower accessibility and continuity.[1,11,27] It is highly probable that the pandemic exacerbated preexisting structural weaknesses in these areas, turning chronic underfunding into acute service failures.
Urban residents and higher-income groups showed significantly better predicted service levels, indicating more resilient access to care during periods of disruption. Similar findings have been reported in global studies documenting service delays, deferred care, and reduced healthcare utilization during COVID-19, with disproportionately greater effects among socioeconomically disadvantaged groups.[14–22] We hypothesize that the resilience observed in higher-income and urban cohorts was largely driven by the rapid digital pivot to telemedicine, as well as the financial capacity to bypass overwhelmed public facilities in favor of private care – options largely inaccessible to rural and low-income populations. These disparities highlight persistent obstacles to achieving equitable, people-centered health systems, as envisioned by WHO’s IPCHS framework.[7]
4.1. Policy and practice implications
The ML-based evaluation framework developed in this study has several implications for health system monitoring and policy planning. By aligning with WHO’s IPCHS model and UHC monitoring approach, the framework could be incorporated into national and regional surveillance systems to track the restoration of essential services and identify emerging inequities.[8,11] The reproducibility and interpretability of the analytic pipeline also support its integration into decision-support tools for resource allocation, including rural outreach, chronic disease follow-up, and stabilization of medication supply chains. These applications are directly aligned with the WHO operational guidance for maintaining essential services during public health emergencies.[2–5]
The findings further indicate that pandemic recovery has been uneven, mirroring earlier analyses showing that poorer and rural populations experienced larger service deficits. Targeted interventions, including community-based care coordination, mobile service delivery, and digital health support, are therefore needed to restore accessibility, continuity, and comprehensiveness for underserved groups. The observed age-related disparities also suggest that older adults should be prioritized within integrated care pathways, in line with WHO ICOPE recommendations.[9]
4.2. Methodological strengths and limitations
This study has several strengths. First, it uses a large, globally representative dataset, the GBD 2021 COVID-19 Health Service Disruption Survey, supplemented by earlier WHO pulse surveys documenting pandemic-related service interruptions.[2–5] Second, the analytic pipeline incorporates systematic preprocessing, structured feature selection based on established ML methodologies, and highly reliable manual labeling supported by robust inter-rater reliability metrics.[30,32,33] Third, the comprehensive comparison of 6 algorithms, followed by model-specific optimization using augmentation, grid/random search, and PSO, provides a rigorous and reproducible workflow aligned with best practices in ML research.[31,34–37,41]
Several limitations should also be acknowledged. First, the dataset is observational and self-reported and is therefore susceptible to recall bias and social desirability bias.[44] Second, although manual annotation showed high reliability, it reflects operationalized quality constructs rather than objective service outcomes. Third, residual confounding may remain, particularly for socioeconomic and regional factors not captured in the survey. Fourth, external validation using independent post-pandemic datasets is required to assess generalizability beyond GBD survey respondents. Future research could incorporate causal inference methods, transfer learning, or Bayesian model averaging to enhance interpretability and robustness.
4.3. Comparison with existing literature
Our findings extend previous ML applications in healthcare, which have largely focused on diagnostic prediction or risk stratification rather than system-level assessment of service quality. While traditional epidemiological evaluations of survey data heavily rely on generalized linear models to identify associations, our ML pipeline offers a comparative advantage. For instance, whereas recent global assessments, such as those by Gertz et al,[45] utilized multivariable logistic regression to identify socioeconomic predictors of forgone care during the pandemic, our optimized SVM and RF models successfully capture complex, nonlinear interactions among demographic variables and service disruption patterns without relying on strict assumptions of data distribution. Prior studies have shown that SVM and RF perform well in high-dimensional clinical datasets, which is consistent with our performance results.[42,43]
Moreover, extensive literature shows that the COVID-19 pandemic caused significant reductions in routine care, emergency visits, vaccinations, and chronic disease management.[14–19] The socioeconomic and regional disparities identified by our models echo global evaluations of excess mortality, deferred care, and disrupted essential health services.[20–22,46] Furthermore, our hypothesis regarding the resilience of urban and high-income cohorts is directly supported by comparative studies like that of Hsiao et al.[47] They demonstrated that the rapid structural shift toward telemedicine during lockdowns disproportionately benefited well-resourced populations with high digital literacy, inadvertently widening the healthcare divide for rural and low-income groups. By moving beyond traditional descriptive statistics, our framework provides a more granular, predictive map of where and for whom these systems failed most critically. By integrating GBD survey data with ML methods, this study makes a novel contribution by moving beyond descriptive analysis to enable multidimensional, respondent-level classification of service quality. This approach is consistent with emerging recommendations to modernize health system performance assessment.[10,27,48]
5. Conclusion
In summary, this study provides a 4-dimensional, ML-enabled evaluation of healthcare service quality during COVID-19 disruptions using a globally representative dataset. The optimized SVM and PSO-enhanced RF models achieved the strongest predictive performance, demonstrating complementary strengths for the analysis of complex, imbalanced health-service data. The analysis reveals substantial socioeconomic and regional inequities in service restoration, highlighting the need for targeted interventions to support disadvantaged groups. By aligning with WHO’s people-centered and UHC frameworks, the proposed pipeline offers a scalable foundation for continuous monitoring and more equitable post-pandemic health system recovery.[8,11]
Acknowledgments
The authors gratefully acknowledge the Institute for Health Metrics and Evaluation (IHME) for providing access to the publicly available 2021 Global Burden of Disease COVID-19 Health Service Disruption Survey dataset, and the World Health Organization for making available the relevant frameworks, guidance documents, and global pulse survey reports that informed the conceptual development of this study. The authors also acknowledge the support of Capital Normal University, Beijing University of Chinese Medicine, and Beijing Tian Tan Hospital, Capital Medical University, for their academic and institutional support.
Author contributions
Conceptualization: Kang Wang.
Methodology: Qian Huang.
Data curation: Ruixiang Xu.
Formal analysis: Kang Wang.
Software: Kang Wang, Ruixiang Xu.
Visualization: Ruixiang Xu.
Writing – original draft: Kang Wang, Ruixiang Xu.
Writing – review & editing: Qian Huang.
Abbreviations:
- COVID-19
- coronavirus disease 2019
- ICOPE
- integrated care for older people
- IPCHS
- integrated people-centered health services
- ML
- machine learning
- PSO
- particle swarm optimization
- RF
- random forest
- SVM
- support vector machine
- UHC
- universal health coverage
- WHO
- World Health Organization
No artificial intelligence tools were used in the preparation of this manuscript.
This work was supported by the “Beijing Natural Science Foundation” (Grant No. 4194072) and the “R&D Program of Beijing Municipal Education Commission” (Grant No. KM201910028001).
The authors have no conflicts of interest to disclose.
The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request. The Global Burden of Disease COVID -19 Health Service Disruption Survey dataset used in this study is publicly accessible via the Institute for Health Metrics and Evaluation (IHME).
How to cite this article: Wang K, Xu R, Huang Q. Tech-based evaluation of healthcare quality during the COVID-19 pandemic. Medicine 2026;105:21(e48850).
References
- [1].GBD 2019 Universal Health Coverage Collaborators. Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1250–84. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [2].World Health Organization. Maintaining essential health services: operational guidance for the COVID-19 context. World Health Organization; 2020. [Google Scholar]
- [3].World Health Organization. Pulse survey on continuity of essential health services during the COVID-19 pandemic: interim report. World Health Organization; 2020. [Google Scholar]
- [4].World Health Organization. Second round of the national pulse survey on continuity of essential health services during the COVID-19 pandemic. World Health Organization; 2021. [Google Scholar]
- [5].World Health Organization. Third round of the global pulse survey on continuity of essential health services during the COVID-19 pandemic. World Health Organization; 2022. [Google Scholar]
- [6].Kringos DS, Boerma WGW, Hutchinson A, Saltman RB, eds. Building Primary Care in a Changing Europe. European Observatory on Health Systems and Policies; 2015. [PubMed] [Google Scholar]
- [7].Jackson GL, Powers BJ, Chatterjee R, et al. The patient-centered medical home: a systematic review. Ann Intern Med. 2013;158:169–78. [DOI] [PubMed] [Google Scholar]
- [8].World Health Organization. Framework on integrated, people-centred health services. World Health Organization; 2016. [Google Scholar]
- [9].World Health Organization. Integrated Care for Older People (ICOPE): Guidance for Person-Centred Assessment and Pathways in Primary Care. World Health Organization; 2019. [Google Scholar]
- [10].Kruk ME, Gage AD, Arsenault C, et al. High-quality health systems in the Sustainable Development Goals era: time for a revolution. Lancet Glob Health. 2018;6:e1196–252. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [11].World Health Organization, International Bank for Reconstruction and Development, The World Bank. Tracking universal health coverage: 2021 global monitoring report. World Health Organization; 2021. [Google Scholar]
- [12].Solar O, Irwin A. A Conceptual Framework for Action on the Social Determinants of Health. World Health Organization; 2010. [Google Scholar]
- [13].Hosseinpoor AR, Bergen N, Barros AJ, Wong KLM, Boerma T, Victora CG. Monitoring subnational regional inequalities in health: measurement approaches and challenges. Int J Equity Health. 2016;15:18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [14].Moynihan R, Sanders S, Michaleff ZA, et al. Impact of COVID-19 pandemic on utilisation of healthcare services: a systematic review. BMJ Open. 2021;11:e045343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [15].Roberton T, Carter ED, Chou VB, et al. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study. Lancet Glob Health. 2020;8:e901–8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [16].Maringe C, Spicer J, Morris M, et al. The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study. Lancet Oncol. 2020;21:1023–34. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [17].Hartnett KP, Kite-Powell A, DeVies J, et al. Impact of the COVID-19 pandemic on emergency department visits—United States, January 1, 2019–May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:699–704. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [18].Santoli JM, Lindley MC, DeSilva MB, et al. Effects of the COVID-19 pandemic on routine pediatric vaccine ordering and administration—United States, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:591–3. [DOI] [PubMed] [Google Scholar]
- [19].Garcia S, Albaghdadi MS, Meraj PM, et al. Reduction in ST-segment elevation cardiac catheterization laboratory activations in the United States during COVID-19 pandemic. J Am Coll Cardiol. 2020;75:2871–2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [20].Woolf SH, Chapman DA, Sabo RT, Weinberger DM, Hill L. Excess deaths from COVID-19 and other causes, March–April 2020. JAMA. 2020;324:510–3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [21].Czeisler ME, Marynak K, Clarke KEN, et al. Delay or avoidance of medical care because of COVID-19-related concerns—United States, June 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1250–7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [22].Ahmed S, Sanghvi K, Yeo D. Telemedicine takes centre stage during COVID-19 pandemic. BMJ Innov. 2020;6:252–4. [DOI] [PubMed] [Google Scholar]
- [23].Obermeyer Z, Emanuel EJ. Predicting the future—big data, machine learning, and clinical medicine. N Engl J Med. 2016;375:1216–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [24].Beam AL, Kohane IS. Big data and machine learning in health care. JAMA. 2018;319:1317–8. [DOI] [PubMed] [Google Scholar]
- [25].Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25:44–56. [DOI] [PubMed] [Google Scholar]
- [26].Institute for Health Metrics and Evaluation. Premise General Population COVID-19 Health Services Disruption Survey 2021. Institute for Health Metrics and Evaluation; 2021. [Google Scholar]
- [27].GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 2017;390:231–66. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [28].van Buuren S. Flexible Imputation of Missing Data. CRC Press; 2018. [Google Scholar]
- [29].Little RJA, Rubin DB. Statistical Analysis with Missing Data. Wiley; 2002. [Google Scholar]
- [30].Chandrashekar G, Sahin F. A survey on feature selection methods. Comput Electr Eng. 2014;40:16–28. [Google Scholar]
- [31].Pedregosa F, Varoquaux G, Gramfort A, et al. Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825–30. [Google Scholar]
- [32].McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb). 2012;22:276–82. [PMC free article] [PubMed] [Google Scholar]
- [33].Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15:155–63. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [34].Bergstra J, Bengio Y. Random search for hyper-parameter optimization. J Mach Learn Res. 2012;13:281–305. [Google Scholar]
- [35].Snoek J, Larochelle H, Adams RP. Practical Bayesian optimization of machine learning algorithms. Adv Neural Inf Process Syst. 2012;25:2951–9. [Google Scholar]
- [36].James G, Witten D, Hastie T, Tibshirani R. An Introduction to Statistical Learning: With Applications in R. Springer; 2021. [Google Scholar]
- [37].Bishop CM. Pattern Recognition and Machine Learning. Springer; 2006. [Google Scholar]
- [38].Saito T, Rehmsmeier M. The precision-recall plot is more informative than the ROC plot when evaluating binary classifiers on imbalanced datasets. PLoS One. 2015;10:e0118432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [39].He H, Garcia EA. Learning from imbalanced data. IEEE Trans Knowl Data Eng. 2009;21:1263–84. [Google Scholar]
- [40].Chawla NV, Bowyer KW, Hall LO, Kegelmeyer WP. SMOTE: synthetic minority over-sampling technique. J Artif Intell Res. 2002;16:321–57. [Google Scholar]
- [41].Zhang Y, Wang S, Ji G. A comprehensive survey on particle swarm optimization algorithm and its applications. Math Probl Eng. 2015;2015:931256. [Google Scholar]
- [42].Cortes C, Vapnik V. Support-vector networks. Mach Learn. 1995;20:273–97. [Google Scholar]
- [43].Breiman L. Random forests. Mach Learn. 2001;45:5–32. [Google Scholar]
- [44].von Elm E, Altman DG, Egger M,, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007;4:e296. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [45].Gertz AH, Pollack CC, Schultheiss MD, Brownstein JS. Delayed medical care and underlying health in the United States during the COVID-19 pandemic: a cross-sectional study. Prev Med Rep. 2022;28:101882. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [46].COVID-19 Excess Mortality Collaborators. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 2022;399:1513–36. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [47].Hsiao V, Chandereng T, Lankton RL, et al. Disparities in telemedicine access: a cross-sectional study of a newly established infrastructure during the COVID-19 pandemic. Appl Clin Inform. 2021;12:445–58. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [48].Countdown to 2030 Collaboration. Countdown to 2030: tracking progress towards universal coverage for reproductive, maternal, newborn, and child health. Lancet. 2018;391:1538–48. [DOI] [PubMed] [Google Scholar]







