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. 1981 Jan;45(1):87–91.

Failure of a Subunit Bovine Herpesvirus 1 Vaccine to Protect Against Experimental Respiratory Disease in Calves

C le Q Darcel, KWF Jericho
PMCID: PMC1320126  PMID: 7272846

Abstract

In two experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups had been previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. These results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cappel R. Comparison of the humoral and cellular immune response after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizations. Arch Virol. 1976;52(1-2):29–35. doi: 10.1007/BF01317862. [DOI] [PubMed] [Google Scholar]
  2. Curtis R. A., Angulo A. A field trial to evaluate an intranasal infectious bovine rhinotracheitis vaccine. Can Vet J. 1974 Nov;15(11):327–330. [PMC free article] [PubMed] [Google Scholar]
  3. Darcel C. Q. Some factors influencing the microtest method for neutralizing antibodies to the virus for neutralizing antibodies to the virus of infectious bovine rhinotracheitis. Can Vet J. 1975 Feb;16(2):59–62. [PMC free article] [PubMed] [Google Scholar]
  4. Darcel C., Bradley J. A., Mitchell D. Immune response of cattle to antigens obtained from bovine herpesvirus 1-infected tissue culture. Can J Comp Med. 1979 Jul;43(3):288–294. [PMC free article] [PubMed] [Google Scholar]
  5. Haralambiev H. Immunogenicity studies on an inactivated IBR vaccine administered into the nasal mucosa. Acta Vet Acad Sci Hung. 1976;26(2):215–217. [PubMed] [Google Scholar]
  6. Jericho K. W., Darcel C. Q. Response of the respiratory tract of calves kept at controlled climatic conditions to bovine Herpesvirus 1 in aerosol. Can J Comp Med. 1978 Apr;42(2):156–167. [PMC free article] [PubMed] [Google Scholar]
  7. Jericho K. W., Langford E. V. Pneumonia in calves produced with aerosols of bovine herpesvirus 1 and Pasteurella haemolytica. Can J Comp Med. 1978 Jul;42(3):269–277. [PMC free article] [PubMed] [Google Scholar]
  8. Jericho K. W., Magwood S. E., Stockdale P. H. Letter to the editor: Prevention of experimental bovine pneumonic pasteurellosis by exposure to IBR virus. Can Vet J. 1976 Jul;17(7):194–195. [PMC free article] [PubMed] [Google Scholar]
  9. Kelling C. L., Schipper I. A., Strum G. E., Carlson R. B., Tilton J. E. Infectious bovine rhinotracheitis (IBR) abortion observations on incidence in vaccinated and non-vaccinated and exposed cattle. Cornell Vet. 1973 Jul;63(3):383–389. [PubMed] [Google Scholar]
  10. Kutinová L., Slichtová V., Vonka V. Immunogenicity of subviral herpes simplex virus preparations. I. Formation of neutralizing antibodies in different animal species after administration of herpes simplex virus solubilized antigens. Arch Virol. 1979;61(1-2):141–147. doi: 10.1007/BF01320598. [DOI] [PubMed] [Google Scholar]
  11. Langford E. V., Dorward W. J. A mycoplasma isolated from cattle with infectious bovine keratoconjunctivitis. Can J Comp Med. 1969 Oct;33(4):275–279. [PMC free article] [PubMed] [Google Scholar]
  12. Lupton H. W., Reed D. E. Evaluation of experimental subunit vaccines for infectious bovine rhinotracheitis. Am J Vet Res. 1980 Mar;41(3):383–390. [PubMed] [Google Scholar]
  13. Martin S. W., Meek A. H., Davis D. G., Thomson R. G., Johnson J. A., Lopez A., Stephens L., Curtis R. A., Prescott J. F., Rosendal S. Factors associated with mortality in feedlot cattle: the Bruce County Beef Cattle Project. Can J Comp Med. 1980 Jan;44(1):1–10. [PMC free article] [PubMed] [Google Scholar]
  14. Rouse B. T., Babiuk L. A. Mechanisms of recovery from Herpesvirus infections -a review. Can J Comp Med. 1978 Oct;42(4):414–427. [PMC free article] [PubMed] [Google Scholar]
  15. Schipper I. A., Kelling C. L. Evaluation of inactivated infectious bovine rhinotracheitis vaccines. Can J Comp Med. 1975 Oct;39(4):402–405. [PMC free article] [PubMed] [Google Scholar]
  16. Stockdale P. H., Jericho K. W., Yates W. D., Darcel C., Langford E. V. Experimental bovine pneumonic pasteurellosis. II. Genesis and prevention. Can J Comp Med. 1979 Jul;43(3):272–279. [PMC free article] [PubMed] [Google Scholar]
  17. le Q Darcel C., Dorward W. J. Recovery of infectious bovine rhinotracheitis virus following corticosteroid treatment of vaccinated animals. Can Vet J. 1975 Mar;16(3):87–88. [PMC free article] [PubMed] [Google Scholar]

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