Skip to main content
NCBI home page
Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1981 Oct;45(4):400–405.

Effect of fusarium T-2 toxin on hematological and biochemical parameters in the rabbit.

P A Gentry, M L Cooper
PMCID: PMC1320172  PMID: 7337872

Abstract

The single intravenous administration of purified T-2 toxin to rabbits to 0.5 mg per kg body weight produced a decrease in hematocrit, while blood cell count, and serum alkaline phosphatase activity. The plasma clotting time, as measured by the activated partial thromboplastin time assay, was prolonged after intravenous T-2 toxin administration. In contrast, the administration of T-2 toxin to rabbits at 2.0 mg per kg body weight by gastric intubation produced oral lesions, diarrhea and anorexia in the animals but did not cause significant alteration in hematological and biochemical parameters. The results suggest that the rabbit may be a suitable model for further examination of the biochemical mechanisms involved in the cytotoxic action of T-2 toxin.

Full text

PDF
400

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Babson A. L., Greeley S. J., Coleman C. M., Phillips G. E. Phenolphthalein monophosphate as a substrate for serum alkaline phosphatase. Clin Chem. 1966 Aug;12(8):482–490. [PubMed] [Google Scholar]
  2. Bamburg J. R., Riggs N. V., Strong F. M. The structures of toxins from two strains of Fusarium tricinctum. Tetrahedron. 1968 Apr;24(8):3329–3336. doi: 10.1016/s0040-4020(01)92631-6. [DOI] [PubMed] [Google Scholar]
  3. Chi M. S., Mirocha C. J., Kurtz H. J., Weaver G., Bates F., Shimoda W., Burmeister H. R. Acute toxicity of T-2 toxin in broiler chicks and laying hens. Poult Sci. 1977 Jan;56(1):103–116. doi: 10.3382/ps.0560103. [DOI] [PubMed] [Google Scholar]
  4. Chi M. S., Mirocha C. J., Kurtz H. J., Weaver G., Bates F., Shimoda W. Subacute toxicity of T-2 toxin in broiler chicks. Poult Sci. 1977 Jan;56(1):306–313. doi: 10.3382/ps.0560306. [DOI] [PubMed] [Google Scholar]
  5. Chi M. S., Robison T. S., Mirocha C. J., Reddy K. R. Acute toxicity of 12,13-epoxytrichothecenes in one-day-old broiler chicks. Appl Environ Microbiol. 1978 Apr;35(4):636–640. doi: 10.1128/aem.35.4.636-640.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DeNicola D. B., Rebar A. H., Carlton W. W., Yagen B. T-2 toxin mycotoxicosis in the guinea-pig. Food Cosmet Toxicol. 1978 Dec;16(6):601–609. doi: 10.1016/s0015-6264(78)80230-2. [DOI] [PubMed] [Google Scholar]
  7. Gentry P. A., Liptrap R. M. Plasma levels of specific coagulation factors and oestrogens in the bitch during pregnancy. J Small Anim Pract. 1977 Apr;18(4):267–275. doi: 10.1111/j.1748-5827.1977.tb05882.x. [DOI] [PubMed] [Google Scholar]
  8. Gentry P. A., Lumsden J. H. Determination of serum albumin in domestic animals using the immediate bromeresol green reaction. Vet Clin Pathol. 1978;7(1):12–15. doi: 10.1111/j.1939-165x.1978.tb00776.x. [DOI] [PubMed] [Google Scholar]
  9. HENRY R. J., CHIAMORI N., GOLUB O. J., BERKMAN S. Revised spectrophotometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic acid dehydrogenase. Am J Clin Pathol. 1960 Oct;34:381–398. doi: 10.1093/ajcp/34.4_ts.381. [DOI] [PubMed] [Google Scholar]
  10. Hayes M. A., Bellamy J. E., Schiefer H. B. Subacute toxicity of dietary T-2 toxin in mice: morphological and hematological effects. Can J Comp Med. 1980 Apr;44(2):203–218. [PMC free article] [PubMed] [Google Scholar]
  11. Hsu I. C., Smalley E. B., Strong F. M., Ribelin W. E. Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle. Appl Microbiol. 1972 Nov;24(5):684–690. doi: 10.1128/am.24.5.684-690.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kosuri N. R., Grove M. D., Yates S. G., Tallent W. H., Ellis J. J., Wolff I. A., Nichols R. E. Response of cattle to mycotoxins of Fusarium tricinctum isolated from corn and fescue. J Am Vet Med Assoc. 1970 Oct 1;157(7):938–940. [PubMed] [Google Scholar]
  13. Kosuri N. R., Smalley E. B., Nichols R. E. Toxicologic studies of Fusarium tricinctum (Corda) Snyder et Hansen from moldy corn. Am J Vet Res. 1971 Nov;32(11):1843–1850. [PubMed] [Google Scholar]
  14. Lutsky I., Mor N., Yagen B., Joffe A. Z. The role of T-2 toxin in experimental alimentary toxic aleukia: a toxicity study in cats. Toxicol Appl Pharmacol. 1978 Jan;43(1):111–124. doi: 10.1016/s0041-008x(78)80036-2. [DOI] [PubMed] [Google Scholar]
  15. Matsumoto H., Ito T., Ueno Y. Toxicological approaches to the metabolities of fusaria. XII. Fate and distribution of T-2 toxin in mice. Jpn J Exp Med. 1978 Oct;48(5):393–399. [PubMed] [Google Scholar]
  16. Matthews J. G., Patterson D. S., Roberts B. A., Shreeve B. J. T-2 toxin and haemorrhagic syndromes of cattle. Vet Rec. 1977 Nov 5;101(19):391–391. doi: 10.1136/vr.101.19.391. [DOI] [PubMed] [Google Scholar]
  17. Miller J. K., Hacking A., Harrison J., Gross V. J. Stillbirths, neonatal mortality and small litters in pigs associated with the ingestion of Fusarium toxin by pregnant sows. Vet Rec. 1973 Nov 24;93(21):555–559. doi: 10.1136/vr.93.21.555. [DOI] [PubMed] [Google Scholar]
  18. Pearson A. W. Biochemical changes produced by Fusarium T-2 toxin in the chicken. Res Vet Sci. 1978 Jan;24(1):92–97. [PubMed] [Google Scholar]
  19. Petrie L., Robb J., Stewart A. F. The identification of T-2 toxin and its association with a haemorrhagic syndrome in cattle. Vet Rec. 1977 Oct 15;101(16):326–326. doi: 10.1136/vr.101.16.326. [DOI] [PubMed] [Google Scholar]
  20. Sato N., Ito T., Kumada H., Ueno Y., Asano K., Saito M., Ohtsubo K., Ueno I., Hatanaka Y. Toxicological approaches to the metabolites of Fusaria. XIII. Hematological changes in mice by a single and repeated administrations of trichothecenes. J Toxicol Sci. 1978 Nov;3(4):335–356. doi: 10.2131/jts.3.335. [DOI] [PubMed] [Google Scholar]
  21. Sato N., Ueno Y., Enomoto M. Toxicological approaches to the toxic metabolites of Fusaria. VIII. Acute and subacute toxicities of T-2 toxin in cats. Jpn J Pharmacol. 1975 Jun;25(3):263–270. doi: 10.1254/jjp.25.263. [DOI] [PubMed] [Google Scholar]
  22. Smalley E. B. T-2 toxin. J Am Vet Med Assoc. 1973 Dec 1;163(11):1278–1281. [PubMed] [Google Scholar]
  23. Weaver G. A., Kurtz H. J., Bates F. Y., Chi M. S., Mirocha C. J., Behrens J. C., Robison T. S. Acute and chronic toxicity of T-2 mycotoxin in swine. Vet Rec. 1978 Dec 9;103(24):531–535. doi: 10.1136/vr.103.24.531. [DOI] [PubMed] [Google Scholar]
  24. Weaver G. A., Kurtz H. J., Mirocha C. J., Bates F. Y., Behrens J. C., Robinson T. S., Gipp W. F. Mycotoxin-induced abortions in swine. Can Vet J. 1978 Mar;19(3):72–74. [PMC free article] [PubMed] [Google Scholar]
  25. Weaver G. A., Kurtz H. J., Mirocha C. J., Bates F. Y., Behrens J. C., Robison T. S. Effect of T-2 toxin on porcine reproduction. Can Vet J. 1978 Nov;19(11):310–314. [PMC free article] [PubMed] [Google Scholar]
  26. Weaver G. A., Kurtz H. J., Mirocha C. J., Bates F. Y., Behrens J. C., Robison T. S., Swanson S. P. The failure of purified T-2 mycotoxin to produce hemorrhaging in dairy cattle. Can Vet J. 1980 Jul;21(7):210–213. [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES