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. 1981 Jul;45(3):212–216.

Experimental parvovirus infection in dogs.

L N Potgieter, J B Jones, C S Patton, T A Webb-Martin
PMCID: PMC1320211  PMID: 7340906

Abstract

Five eight week old dogs were inoculated orally and intranasally with cell culture origin canine parvovirus. Three dogs became depressed and anorectic and developed a mild (one dog) to severe diarrhea five days postinfection. The remaining dogs had subclinical infections but developed a lymphopenia followed by a transient lymphocytosis. The ill dogs developed mild (one dog) to severe neutropenia and a moderate lymphopenia. One died nine days postinfection. Recovery was associated with cessation of viral excretion and with lymphocytosis and antibody production. Two of three dogs challenged intragastrically developed mild clinical signs and a moderate panleukopenia four to eight days postinfection. The pathological changes of the experimental disease were very similar to that of spontaneous disease. Bone marrow changes included a severe granulocytic and mild erythroid depletion. The pathogenesis of canine parvovirus infection is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appel M. J., Scott F. W., Carmichael L. E. Isolation and immunisation studies of a canine parco-like virus from dogs with haemorrhagic enteritis. Vet Rec. 1979 Aug 25;105(8):156–159. doi: 10.1136/vr.105.8.156. [DOI] [PubMed] [Google Scholar]
  2. Black J. W., Holscher M. A., Powell H. S., Byerly C. S. Parvoviral enteritis and panleukopenia in dogs. Vet Med Small Anim Clin. 1979 Jan;74(1):47–50. [PubMed] [Google Scholar]
  3. Burtonboy G., Coignoul F., Delferriere N., Pastoret P. P. Canine hemorrhagic enteritis: detection of viral particles by electron microscopy. Arch Virol. 1979;61(1-2):1–11. doi: 10.1007/BF01320586. [DOI] [PubMed] [Google Scholar]
  4. Carpenter J. L., Roberts R. M., Harpster N. K., King N. W., Jr Intestinal and cardiopulmonary forms of parvovirus infection in a litter of pups. J Am Vet Med Assoc. 1980 Jun 1;176(11):1269–1273. [PubMed] [Google Scholar]
  5. Cooper B. J., Carmichael L. E., Appel M. J., Greisen H. Canine viral enteritis. II. Morphologic lesions in naturally occurring parvovirus infection. Cornell Vet. 1979 Apr;69(3):134–144. [PubMed] [Google Scholar]
  6. Crandell R. A., Fabricant C. G., Nelson-Rees W. A. Development, characterization, and viral susceptibility of a feline (Felis catus) renal cell line (CRFK). In Vitro. 1973 Nov-Dec;9(3):176–185. doi: 10.1007/BF02618435. [DOI] [PubMed] [Google Scholar]
  7. Csiza C. K., Scott F. W., De Lahunta A., Gillespie J. H. Pathogenesis of feline panleukopenia virus in susceptible newborn kittens I. Clinical signs, hematology, serology, and virology. Infect Immun. 1971 Jun;3(6):833–837. doi: 10.1128/iai.3.6.833-837.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gagnon A. N., Povey R. C. A possible parvovirus associated with an epidemic gastroenteritis of dogs in Canada. Vet Rec. 1979 Mar 24;104(12):263–264. doi: 10.1136/vr.104.12.263. [DOI] [PubMed] [Google Scholar]
  9. Hayes M. A., Russell R. G., Babiuk L. A. Sudden death in young dogs with myocarditis caused by parvovirus. J Am Vet Med Assoc. 1979 Jun 1;174(11):1197–1203. [PubMed] [Google Scholar]
  10. Kelly W. R. An enteric disease of dogs reselmbing feline panleucopaenia. Aust Vet J. 1978 Dec;54(12):593–593. doi: 10.1111/j.1751-0813.1978.tb02426.x. [DOI] [PubMed] [Google Scholar]
  11. Nelson D. T., Eustis S. L., McAdaragh J. P., Stotz I. Lesions of spontaneous canine viral enteritis. Vet Pathol. 1979 Nov;16(6):680–686. doi: 10.1177/030098587901600606. [DOI] [PubMed] [Google Scholar]
  12. Osterhaus A. D., van Steenis G., de Kreek P. Isolation of a virus closely related to feline panleukopenia virus from dogs with diarrhea. Zentralbl Veterinarmed B. 1980;27(1):11–21. doi: 10.1111/j.1439-0450.1980.tb01632.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pletcher J. M., Toft J. D., 2nd, Frey R. M., Casey H. W. Histopathologic evidence for parvovirus infection in dogs. J Am Vet Med Assoc. 1979 Oct 15;175(8):825–828. [PubMed] [Google Scholar]
  14. Potgieter L. N., Aldridge P. L. Use of the indirect fluorescent antibody test in the detection of bovine respiratory syncytial virus antibodies in bovine serum. Am J Vet Res. 1977 Sep;38(9):1341–1343. [PubMed] [Google Scholar]
  15. Robinson W. F., Wilcox G. E., Flower R. L. Canine parvoviral disease: experimental reproduction of the enteric form with a parvovirus isolated from a case of myocarditis. Vet Pathol. 1980 Sep;17(5):589–599. doi: 10.1177/030098588001700508. [DOI] [PubMed] [Google Scholar]
  16. Rossini A. A., Williams R. M., Appel M. C., Like A. A. Sex differences in the multiple-dose streptozotocin model of diabetes. Endocrinology. 1978 Oct;103(4):1518–1520. doi: 10.1210/endo-103-4-1518. [DOI] [PubMed] [Google Scholar]
  17. Smith J. R., Farmer T. S., Johnson R. H. Serological observations on the epidemiology of parvovirus enteritis of dogs. Aust Vet J. 1980 Mar;56(3):149–150. doi: 10.1111/j.1751-0813.1980.tb05661.x. [DOI] [PubMed] [Google Scholar]

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