Skip to main content
NCBI home page
Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1981 Jul;45(3):330–332.

Endotoxemia following experimental intestinal strangulation obstruction in ponies.

J N Moore, N A White, J N Berg, C M Trim, H E Garner
PMCID: PMC1320229  PMID: 7200383

Abstract

Experimental small intestinal strangulation obstruction was produced in anesthetized ponies. The limulus amoebocyte lysate test demonstrated the presence of endotoxin in the general circulation 60 and 120 minutes following restoration of mesenteric blood flow. Mucosal degeneration, with loss of villus epithelial cells, was demonstrated coincident with endotoxemia. The findings were consistent with an ischemia-mediated alteration in the intestinal barrier to endotoxin.

Full text

PDF
330

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berg J. N., Nausley C. A., Riegle L. Heat extraction of animal plasma in preparation for endotoxin testing with the limulus amebocyte lysate test. Am J Vet Res. 1979 Jul;40(7):1048–1049. [PubMed] [Google Scholar]
  2. Burrows G. E., Cannon J. Endotoxemia induced by rapid intravenous injection of Escherichia coli in anesthetized ponies. Am J Vet Res. 1970 Nov;31(11):1967–1973. [PubMed] [Google Scholar]
  3. CARROLL E. J., SCHALM O. W., WHEAT J. D. ENDOTOXEMIA IN A HORSE. J Am Vet Med Assoc. 1965 Jun 1;146:1300–1303. [PubMed] [Google Scholar]
  4. Gans H., Matsumoto K. The escape of endotoxin from the intestine. Surg Gynecol Obstet. 1974 Sep;139(3):395–402. [PubMed] [Google Scholar]
  5. Hinshaw L. B., Benjamin B., Holmes D. D., Beller B., Archer L. T., Coalson J. J., Whitsett T. Responses of the baboon to live Escherichia coli organisms and endotoxin. Surg Gynecol Obstet. 1977 Jul;145(1):1–11. [PubMed] [Google Scholar]
  6. Jacob A. I., Goldberg P. K., Bloom N., Degenshein G. A., Kozinn P. J. Endotoxin and bacteria in portal blood. Gastroenterology. 1977 Jun;72(6):1268–1270. [PubMed] [Google Scholar]
  7. Levin J., Poore T. E., Young N. S., Margolis S., Zauber N. P., Townes A. S., Bell W. R. Gram-negative sepsis: detection of endotoxemia with the limulus test. With studies of associated changes in blood coagulation, serum lipids, and complement. Ann Intern Med. 1972 Jan;76(1):1–7. doi: 10.7326/0003-4819-76-1-1. [DOI] [PubMed] [Google Scholar]
  8. Mori K., Matsumoto K., Gans H. On the in vivo clearance and detoxification of endotoxin by lung and liver. Ann Surg. 1973 Feb;177(2):159–163. doi: 10.1097/00000658-197302000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nolan J. P., Ali M. V. Effect of cholestyramine on endotoxin toxicity and absorption. Am J Dig Dis. 1972 Feb;17(2):161–166. doi: 10.1007/BF02232738. [DOI] [PubMed] [Google Scholar]
  10. RAVIN H. A., ROWLEY D., JENKINS C., FINE J. On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal. J Exp Med. 1960 Nov 1;112:783–792. doi: 10.1084/jem.112.5.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shatila A. H., Chamberlain B. E., Webb W. R. Current status of diagnosis and management of strangulation obstruction of the small bowel. Am J Surg. 1976 Sep;132(3):299–303. doi: 10.1016/0002-9610(76)90379-2. [DOI] [PubMed] [Google Scholar]
  12. White N. A., Moore J. N., Trim C. M. Mucosal alterations in experimentally induced small intestinal strangulation obstruction in ponies. Am J Vet Res. 1980 Feb;41(2):193–198. [PubMed] [Google Scholar]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES