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. 1991 Sep;56(2):289–302. doi: 10.1901/jeab.1991.56-289

Effects of d-amphetamine on responding under second-order schedules of reinforcement with paired and nonpaired brief stimuli.

S L Cohen 1
PMCID: PMC1323103  PMID: 1955818

Abstract

Three pigeons were studied under a multiple schedule in which pecks in each component were reinforced according to a variable-interval 120-s second-order schedule with fixed-interval 60-s units. In the first component of the multiple schedule, the completion of a fixed interval produced either food or a 4-s change in key color plus houselight illumination. In the second component an identical schedule was in effect, but the stimulus was a 0.3-s change in key color. Both long and short brief stimuli were not paired with food presentations in Conditions 1 and 3 and were paired with food in Condition 2. There were no consistent differences in response patterns under paired and nonpaired brief-stimulus conditions when the stimulus was a 4-s change in key color accompanied by houselight illumination. However, pairing the 0.3-s key-color change with food presentations resulted in higher indices of curvature and lower response rates in the early segments of the fixed interval than when the stimulus was not paired with food presentations. Low doses of d-amphetamine (0.3 and 1 mg/kg) produced small and inconsistent increases in overall response rates, and higher doses (3 and 10 mg/kg) decreased overall response rates. d-Amphetamine altered response patterns within fixed intervals by decreasing the indices of curvature and increasing response rates in the early segments of the fixed interval. Response rates and patterns under paired and nonpaired brief-stimulus conditions were not differentially affected by d-amphetamine. Thus, evidence for the enhancement of the conditioned reinforcement effects of psychomotor stimulant drugs was not found with the second-order schedules used in the present study.

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Selected References

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  1. Barrett J. E., Katz J. L., Glowa J. R. Effects of d-amphetamine on responding of squirrel monkeys maintained under second-order schedules of food presentation, electric shock presentation or stimulus-shock termination. J Pharmacol Exp Ther. 1981 Sep;218(3):692–700. [PubMed] [Google Scholar]
  2. Barrett J. E., Valentine J. O., Katz J. L. Effects of chlordiazepoxide and d-amphetamine on responding of squirrel monkeys maintained under concurrent or second-order schedules of response-produced food or electric shock presentation. J Pharmacol Exp Ther. 1981 Oct;219(1):199–206. [PubMed] [Google Scholar]
  3. Bond N. W., Sanger D. J., Blackman D. E. Effects of d-amphetamine on the behavior of pigeons maintained by a second-order schedule of reinforcement. J Pharmacol Exp Ther. 1975 Aug;194(2):327–331. [PubMed] [Google Scholar]
  4. Bradshaw C. M., Ruddle H. V., Szabadi E. Relationship between response rate and reinforcement frequency in variable-interval schedules: III. The effect of d-amphetamine. J Exp Anal Behav. 1981 Jul;36(1):29–39. doi: 10.1901/jeab.1981.36-29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Byrd L. D., Marr M. J. Relations between patterns of responding and the presentation of stimuli under second-order schedules. J Exp Anal Behav. 1969 Sep;12(5):713–722. doi: 10.1901/jeab.1969.12-713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Catania A. C., Reynolds G. S. A quantitative analysis of the responding maintained by interval schedules of reinforcement. J Exp Anal Behav. 1968 May;11(3 Suppl):327–383. doi: 10.1901/jeab.1968.11-s327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cohen S. L., Branch M. N. Food-paired stimuli as conditioned reinforcers: effects of d-amphetamine. J Exp Anal Behav. 1991 Sep;56(2):277–288. doi: 10.1901/jeab.1991.56-277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cohen S. L., Calisto G., Lentz B. E. Separating the reinforcing and discriminative properties of brief-stimulus presentations in second-order schedules. J Exp Anal Behav. 1979 Sep;32(2):149–156. doi: 10.1901/jeab.1979.32-149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cohen S. L., Calisto G. The effects of brief-stimulus presentations in fixed-ratio second-order schedules. J Exp Anal Behav. 1981 Nov;36(3):329–342. doi: 10.1901/jeab.1981.36-329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cohen S. L., Lentz B. E. Factors influencing responding under multiple schedules of conditioned and unconditioned reinforcement. J Exp Anal Behav. 1976 Nov;26(3):395–404. doi: 10.1901/jeab.1976.26-395. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cohen S. L., Stubbs D. A. Discriminative properties of briefly presented stimuli. J Exp Anal Behav. 1976 Jan;25(1):15–25. doi: 10.1901/jeab.1976.25-15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. De Lorge J. Fixed-interval behavior maintained by conditioned reinforcement. J Exp Anal Behav. 1967 May;10(3):271–276. doi: 10.1901/jeab.1967.10-271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ettenberg A., Koob G. F., Bloom F. E. Response artifact in the measurement of neuroleptic-induced anhedonia. Science. 1981 Jul 17;213(4505):357–359. doi: 10.1126/science.7244622. [DOI] [PubMed] [Google Scholar]
  14. FRY W., KELLEHER R. T., COOK L. A mathematical index of performance on fixed-interval schedules of reinforcement. J Exp Anal Behav. 1960 Jul;3:193–199. doi: 10.1901/jeab.1960.3-193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Files F.J., Branch M.N., Clody D. Effects of methylphenidate on responding under extinction in the presence and absence of conditioned reinforcement. Behav Pharmacol. 1989;1(2):113–121. [PubMed] [Google Scholar]
  16. Glick S. D., Weaver L. M., Meibach R. C. Amphetamine enhancement of reward asymmetry. Psychopharmacology (Berl) 1981;73(4):323–327. doi: 10.1007/BF00426459. [DOI] [PubMed] [Google Scholar]
  17. Goldberg S. R. Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J Pharmacol Exp Ther. 1973 Jul;186(1):18–30. [PubMed] [Google Scholar]
  18. Goldberg S. R., Kelleher R. T., Goldberg D. M. Fixed-ratio responding under second-order schedules of food presentation or cocaine injection. J Pharmacol Exp Ther. 1981 Jul;218(1):271–281. [PubMed] [Google Scholar]
  19. Goldberg S. R., Kelleher R. T., Morse W. H. Second-order schedules of drug injection. Fed Proc. 1975 Aug;34(9):1771–1776. [PubMed] [Google Scholar]
  20. Goldberg S. R., Morse W. H., Goldberg D. M. Behavior maintained under a second-order schedule by intramuscular injection of morphine or cocaine in rhesus monkeys. J Pharmacol Exp Ther. 1976 Oct;199(1):278–286. [PubMed] [Google Scholar]
  21. Goldberg S. R. Stimuli associated with drug injections as events that control behavior. Pharmacol Rev. 1975 Sep;27(3):325–340. [PubMed] [Google Scholar]
  22. Gonzalez F. A., Goldberg S. R. Effects of cocaine and d-amphetamine on behavior maintained under various schedules of food presentation in squirrel monkeys. J Pharmacol Exp Ther. 1977 Apr;201(1):33–43. [PubMed] [Google Scholar]
  23. Herrnstein R. J. Formal properties of the matching law. J Exp Anal Behav. 1974 Jan;21(1):159–164. doi: 10.1901/jeab.1974.21-159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Heyman G. M. A parametric evaluation of the hedonic and motoric effects of drugs: pimozide and amphetamine. J Exp Anal Behav. 1983 Sep;40(2):113–122. doi: 10.1901/jeab.1983.40-113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Hoffman D. C., Beninger R. J. The effects of pimozide on the establishment of conditioned reinforcement as a function of the amount of conditioning. Psychopharmacology (Berl) 1985;87(4):454–460. doi: 10.1007/BF00432512. [DOI] [PubMed] [Google Scholar]
  26. Howell L. L., Byrd L. D., Marr M. J. Differential effects of cocaine and pentobarbital on fixed-interval and random-interval performance. J Exp Anal Behav. 1988 May;49(3):411–428. doi: 10.1901/jeab.1988.49-411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. KELLEHER R. T., GOLLUB L. R. A review of positive conditioned reinforcement. J Exp Anal Behav. 1962 Oct;5:543–597. doi: 10.1901/jeab.1962.5-s543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Katz J. L. A comparison of responding maintained under second-order schedules of intramuscular cocaine injection or food presentation in squirrel monkeys. J Exp Anal Behav. 1979 Nov;32(3):419–431. doi: 10.1901/jeab.1979.32-419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Katz J. L. Second-order schedules of intramuscular cocaine injection in the squirrel monkey: comparisons with food presentation and effects of d-amphetamine and promazine. J Pharmacol Exp Ther. 1980 Mar;212(3):405–411. [PubMed] [Google Scholar]
  30. Kelleher R. T. Characteristics of behavior controlled by scheduled injections of drugs. Pharmacol Rev. 1975 Sep;27(3):307–323. [PubMed] [Google Scholar]
  31. Kelleher R. T. Conditioned reinforcement in second-order schedules. J Exp Anal Behav. 1966 Sep;9(5):475–485. doi: 10.1901/jeab.1966.9-475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Kelleher R. T., Goldberg S. R. Fixed-interval responding under second-order schedules of food presentation or cocaine injection. J Exp Anal Behav. 1977 Nov;28(3):221–231. doi: 10.1901/jeab.1977.28-221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Marr M. J. Effects of chlorpromazine in the pigeon under a second-order schedule of food presentation. J Exp Anal Behav. 1970 May;13(3):291–299. doi: 10.1901/jeab.1970.13-291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Marr M. J., Zeiler M. D. Schedules of response-independent conditioned reinforcement. J Exp Anal Behav. 1974 May;21(3):433–444. doi: 10.1901/jeab.1974.21-433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Mason S. T., Robbins T. W. Noradrenaline and conditioned reinforcement. Behav Neural Biol. 1979 Apr;25(4):523–534. doi: 10.1016/s0163-1047(79)90302-9. [DOI] [PubMed] [Google Scholar]
  36. Robbins T. W., Koob G. F. Pipradrol enhances reinforcing properties of stimuli paired with brain stimulation. Pharmacol Biochem Behav. 1978 Mar;8(3):219–222. doi: 10.1016/0091-3057(78)90308-8. [DOI] [PubMed] [Google Scholar]
  37. Robbins T. W. The acquisition of responding with conditioned reinforcement: effects of pipradrol, methylphenidate, d-amphetamine, and nomifensine. Psychopharmacology (Berl) 1978 Jun 15;58(1):79–87. doi: 10.1007/BF00426794. [DOI] [PubMed] [Google Scholar]
  38. Spealman R. D., Goldberg S. R. Maintenance of schedule-controlled behavior by intravenous injections of nicotine in squirrel monkeys. J Pharmacol Exp Ther. 1982 Nov;223(2):402–408. [PubMed] [Google Scholar]
  39. Stubbs D. A., Cohen S. L. Second-order schedules: comparison of different procedures for scheduling paired and nonpaired brief stimuli. J Exp Anal Behav. 1972 Nov;18(3):403–413. doi: 10.1901/jeab.1972.18-403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Stubbs D. A. Second-order schedules and the problem of conditioned reinforcement. J Exp Anal Behav. 1971 Nov;16(3):289–313. doi: 10.1901/jeab.1971.16-289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Stubbs D. A., Vautin S. J., Reid H. M., Delehanty D. L. Discriminative functions of schedule stimuli and memory: a combination of schedule and choice procedures. J Exp Anal Behav. 1978 Mar;29(2):167–180. doi: 10.1901/jeab.1978.29-167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Winsauer P. J., Thompson D. M., Moerschbaecher J. M. Comparison of drug effects on fixed-ratio performance and chain performance maintained under a second-order fixed-ratio schedule. J Exp Anal Behav. 1985 Nov;44(3):367–376. doi: 10.1901/jeab.1985.44-367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Wise R. A., Spindler J., deWit H., Gerberg G. J. Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food. Science. 1978 Jul 21;201(4352):262–264. doi: 10.1126/science.566469. [DOI] [PubMed] [Google Scholar]

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