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. 2026 Jun 8;55(6):afag168. doi: 10.1093/ageing/afag168

Efficacy of traditional Chinese exercises on cognitive function in older adults: a systematic review and meta-analysis of randomised controlled trials

Bin Li 1,#, Lirong Yu 2,#, Na Li 3,#, Kaisy Xinhong Ye 4, Jiuyu Guo 5,6, Luwen Cao 7, Jiatong Shan 8,9,10, Yecheng Li 11, Xiu Wang 12, Tih-Shih Lee 13, Brian K Kennedy 14,15,16, John Suckling 17, Andrea Maier 18,19, Wenbin Wu 20, Lei Feng 21,22,
PMCID: PMC13245186  PMID: 42258338

Abstract

Background

Cognitive impairment is a significant health concern among older adults, highlighting the need for non-pharmacological interventions, such as mind–body exercises. However, a comprehensive synthesis of the effects of various traditional Chinese exercises (TCEs) on cognitive function in older adults is lacking.

Methods

A systematic review and meta-analysis of randomised controlled trials (RCTs) was conducted. Six databases were searched from inception to 2 May 2024 for studies examining the effects of TCEs on cognitive outcomes in adults aged 60 years and older. Studies were included if they were RCTs involving TCEs and reported outcome measures for global cognition, or individual cognitive domains.

Results

Twenty-eight RCTs with a total of 2297 participants were included. Meta-analysis revealed that TCEs led to significant improvements in global cognition: Montreal Cognitive Assessment [mean differences (MD) = 1.67; 95% confidence interval (CI): (1.20, 2.14)], Mini-Mental State Examination [MD = 0.76; 95% CI: (0.04, 1.48)]; executive function: Trail Making Test (B-A) [MD = −7.96; 95% CI: (−15.34, −0.59)], Category Fluency for Animals [MD = 2.96, 95% CI (2.08, 3.85)]; working memory: Digit Span-Backwards [MD = 0.48; 95% CI: (0.07, 0.90)]; processing speed: Digit Symbol Coding [MD = 4.16; 95% CI: (1.82, 6.50)]; memory function: Memory Quotient [MD = 13.13; 95% CI: (4.06, 22.20)], Auditory Verbal Learning Test: immediate recall [MD = 1.13; 95% CI: (0.07, 2.20)], short-term delayed recognition [MD = 0.80; 95% CI: (0.28, 1.32)] and long-term delayed recognition [MD = 1.38; 95% CI: (0.68, 2.09)].

Conclusions

TCEs are effective in improving cognitive function in older adults, particularly in domains such as global cognition, executive function, working memory, processing speed and memory function. However, given the methodological limitations and heterogeneity of the included studies, these findings require confirmation in further large-scale, high-quality RCTs.

Keywords: cognitive function, older adults, traditional Chinese exercises, meta-analysis, randomised controlled trial, systematic review

Introduction

Cognitive ability is crucial for older adults to maintain functional independence, including managing daily activities, finances and medications. Population ageing poses a major global health and economic challenge: by 2050, the number of individuals over 60 years is expected to reach 2.1 billion [1], with those aged 80 years or older tripling to 426 million. Cognitive decline, driven by neuronal dysfunction and loss, is a common consequence of ageing [2]. The prevalence of dementia is projected to rise from 55 million in 2019 to 139 million in 2050 [3], with associated global costs increasing from US$1.3 trillion in 2019 to an estimated $2.8 trillion by 2030 [4].

Alzheimer’s disease (AD), the most common form of dementia, is a neurodegenerative disease characterised by cognitive dysfunctions and memory impairment [5, 6]. Mild cognitive impairment (MCI), a transitional stage between normal cognition and dementia, progresses to dementia in 30%–40% of cases within 5 years [7, 8]. Dementia poses a significant public health burden on older adults, with high costs for medical and informal caregiving [9]. Increasing evidence suggests that lifestyle factors can influence the risk of dementia and MCI. The 2024 Lancet Commissions report indicated that 45% of dementia cases could be potentially prevented or delayed by addressing modifiable risk factors, with physical inactivity as a key contributor [10]. The FINGER trial underscored the importance of exercise in dementia prevention [11], and a recent network meta-analysis confirmed the benefits of exercise across multiple cognitive domains, influenced by frequency, intensity, duration, type, volume or total intervention length and progression [12]. Emerging evidence suggests that mind–body exercise, including traditional Chinese exercises (TCEs), may hold potential for ameliorating neurodegenerative disorders.

TCEs, originated in China about 3000 years ago, are multimodal mind–body exercises that combine moderate movements, breathing exercises, social interaction and meditation [13], making them particularly suitable for older adults who may struggle with high-intensity fitness regimens. Various forms of TCEs, including Tai Chi [14], Baduanjin (Eight Brocades of Qigong) [15], Yijinjing (Muscle Tendon Strengthening Classic) [16], Wuqinxi (Five Animals Qigong Practice) [17], Liuzijue (The Six Healing Sounds) [18], traditionally used to prevent and manage cognitive decline. Evidence supports cognitive benefits for Tai Chi in older adults with type 2 diabetes (T2D) and MCI [19], and for Baduanjin in enhancing cognitive ability and reducing physical frailty in cognitive frailty [20]. A bibliometric analysis [21] highlights growing research on TCEs for neurodegenerative diseases.

Despite this increasing interest, a comprehensive review of cognitive effects of various TCEs is lacking. Therefore, this systematic review and meta-analysis of RCTs aims to address this gap in older adults.

Methods

This study was registered in PROSPERO with reference number #CRD 42024539587 and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist [22].

Search strategy

A systematic search was conducted in PubMed, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science and Scopus from database inception to 2 May 2024, using a combination of Medical Subject Headings (MeSH) terms and free-text terms related to participant characteristics, interventions and outcomes. The complete search strategies are provided in Appendix S1.

Following deduplication, two reviewers independently screened titles and abstracts, and subsequently reviewed full-text articles to determine eligibility. Discrepancies were resolved through discussion or, when necessary, adjudication by a senior reviewer.

Selection criteria

Studies were included if they met the following criteria: (i) participant: adults aged 60 years and older; (ii) intervention: at least one arm of the study involved a TCE intervention; (iii) comparison: control group participants engaged in either an active (non-TCE activities such as fitness training, simple handicrafts, health education) or passive (e.g. usual care, waitlist) comparison; (iv) outcomes: reported at least one measure of cognitive function (e.g. global cognition, executive function, working memory); (v) study design: RCT.

Studies were excluded if they met any of the following criteria: (i) not published in English or the full-text was unavailable; (ii) the intervention combined TCEs with other active interventions; (iii) the control group received another form of TCEs; (iv) duplicate reporting of the same study; (v) publication type was a review, editorial, conference abstract, commentary or protocol; (vi) studies that reported only neuroimaging, physiological or biomarker outcomes without including any standardised cognitive function scale tests.

Data extraction

Data were extracted independently by two authors using a structured data extraction form. The form was developed based on previous review experience and was refined iteratively during the initial extraction phase to ensure clarity and consistency. Any discrepancies between extractors were resolved through discussion or with the input of a third reviewer. The extracted data included:

General study information: author names, year of publication, country/location of study. Participant demographics: health condition, sample size, mean age, sex. Health condition was categorised according to the classifications reported in the original studies.

Intervention characteristics: number of study arms, type(s) of TCEs, frequency and duration of the intervention, mode of instruction, characteristics of the control group and cognitive outcome measures. Data for cognitive outcomes were extracted at the time points reported by the primary studies. To ensure comparability, the primary analysis focused on the first post-intervention time point, defined as the assessment conducted immediately after the final intervention session.

Risk of bias assessment

Two independent reviewers assessed the risk of bias in each included study using the Cochrane Collaboration’s tool for assessing the risk of bias in randomised trials. This tool evaluates bias across six domains: selection bias, performance bias, detection bias, attrition bias and reporting bias and other potential sources of bias. Each domain was rated as low risk, unclear risk and high risk. Discrepancies between reviewers were resolved through consensus with the broader research team.

Statistical analysis and data synthesis

Meta-analyses were carried out only for outcomes measured by common, standardised tests that were used by at least two independent studies. All meta-analyses in this study were conducted using the Review Manager (RevMan 5.4), with respective meta-regressions performed in STATA 17.0 [23]. Given the multiple cognitive domains and analyses, we did not apply formal multiplicity corrections. Instead, we pre-specified Montreal Cognitive Assessment (MoCA) as the primary outcome, defined a limited set of key secondary outcomes, and treated the remaining analyses as exploratory, interpreting them cautiously. An alpha level of 0.05 was used for all hypothesis testing. Between-study heterogeneity was quantified by I2 statistic, with values of 25%, 50% and 75% indicating low, medium and high heterogeneity, respectively. Mean differences (MDs) and standard deviations (SDs) were calculated alone with their corresponding 95% confidence intervals (CIs).

To assess the robustness of findings, subgroup analyses were carried out based on different characteristics of the control group. The strategy for subgroup analyses was pre-specified in our PROSPERO protocol, which stated: ‘Additional subgroup analyses will be considered depending on the retrieved data.’ We also performed sensitivity analyses based on a leave-one-out methods.

We used a random-effects model to pool the effect of traditional exercise on cognitive function, given anticipated clinical and methodological heterogeneity across studies. To explore potential sources of heterogeneity, we pre-specified meta-regression analyses for outcomes with at least 10 studies, examining moderators including age, sex, health status, type of TCE, instruction mode, control group type, intervention frequency and duration.

Publication bias

Publication bias was visually assessed using funnel plots generated in RevMan 5.4. Egger’s regression tests [24] were performed in STATA 17.0 for outcomes with 10 or more studies to formally test for asymmetry. A P value <.05 was considered statistically significant, indicating evidence of publication bias.

Results

Study selection

A total of 2404 records were identified through the database searches (Figure 1). After removing duplicates (n = 714), 1690 articles were screened by titles and abstract. Of these, 125 articles were considered potentially eligible, and full-text were retrieved for 106 of these articles. Following full-text review, 28 RCTs (n = 2297) met the inclusion criteria and were included in the meta-analysis.

Figure 1.

For image description, please refer to the figure legend and surrounding text.

PRISMA flow diagram of screening and selection process.

Characteristics of included studies

The characteristics of the included studies are summarised in Appendix S2.

Study setting and participant characteristics

Studies were conducted in China (n = 20), USA (n = 7) or Thailand (n = 1). Participant diagnoses varied, with MCI (n = 11), non-dementia with MoCA>22 or Mini-Mental State Examination (MMSE)>24 (n = 6), cognitive frailty (n = 2), Parkinson’s disease (n = 2), and one study each for mild dementia, geriatric depression, heart failure, cognitive impairment and osteoarthritic knee, T2D with MCI, post-stroke cognitive impairment, and multiple chronic conditions without dementia.

Intervention characteristics

The most frequently studied TCEs were Tai Chi (18 studies, 1793 participants), Baduanjin (7 studies, 391 participants), other forms including Wuqinxi, Liuzijue (Six Healing Sounds) and Wu Xing Ping Heng Gong (3 studies, 113 participants). Instruction modes included on-site teaching by coach (25 studies), online guidance (1), exercise video (1), not mentioned (1), control group conditions were categorised as active group (16) and care-as-usual group (12).

Training load

Session duration varied: 60 minutes was most common (16 studies), followed by 120 (2), 50 (3), 40 (2), 30 (2) and 20 minutes (3). Frequency was typically 3 times/week (17 studies), with other schedules including 7, 5, 4, 2, 1 or 1–2 times/week. Intervention duration ranged from 10 to 52 weeks, most frequently 24 weeks (10 studies) or 12 weeks (7 studies). Detailed parameters for each study are summarised in Table S2.

Outcome measures

Commonly reported cognitive domains and assessment tools included: global cognition: MoCA (n = 13), MMSE (n = 7); executive function: Trail Making Test (TMT) (n = 9), Category Fluency for Animals (n = 3); working memory: Digit Span-Backwards (DS-B) (n = 5); processing speed: Digit Symbol Coding (DSC) (n = 3); attention: Digit Span-Forwards (DS-F) (n = 4); visuospatial ability: Clock Drawing Task (CDT) (n = 2); memory function: Memory Quotient (MQ) (n = 4), Auditory Verbal Learning Test (AVLT) (n = 6).

Risk of bias in included studies

The risk of bias across domains is summarised in Appendix S3. (i) Random sequence generation (7.1% high risk, 39.3% unclear, 53.6% low risk), (ii) allocation concealment (10.7% high risk, 17.9% unclear, 71.4% low risk), (iii) blinding of participants and personnel (100% high risk, 0% unclear, 0% low risk), (iv) blinding of outcome assessment (0% high risk, 64.3% unclear, 35.7% low risk), (v) incomplete outcome data (10.7% high risk, 10.7% unclear, 78.6% low risk), (vi) selective reporting (14.3% high risk, 10.7% unclear, 75% low risk) and (vii) other bias (28.6% high risk, 46.4% unclear, 25% low risk).

Effectiveness on cognitive function

Global cognition

Thirteen RCTs (n = 978) reported outcomes for the MoCA [25]. Meta-analysis revealed a significant positive effect of TCEs on global cognition [MD = 1.67; 95% CI: (1.20, 2.14); P < .00001; Figure 2a]. Heterogeneity between studies was classified medium (P = .02; I2 = 49%). Subgroup analyses based on the type of TCE and the characteristics of the control group showed that TCEs were associated with greater improvements in MoCA scores compared to both active control [MD = 1.66, 95% CI (1.01, 2.30); P < .00001] and care-as-usual group [MD = 1.73, 95% CI (0.98, 2.48); P < .00001].

Figure 2.

For image description, please refer to the figure legend and surrounding text.

Forest plot of global cognition. (a) Montreal Cognitive Assessment (MoCA); (b) Mini-Mental State Examination (MMSE).

Seven RCTs (n = 793) reported outcomes for the MMSE [26]. Meta-analysis identified a significant positive effect of TCEs on global cognition [MD = 0.76; 95% CI: (0.04, 1.48); P = .04; Figure 2b] with high heterogeneity (P = .0006; I2 = 74%). In subgroup analyses, a significant difference was noted when the control group was care-as-usual [MD = 2.01, 95% CI (1.22, 2.79); P < .00001], but not when the control group was active [MD = 0.34, 95% CI (−0.19, 0.87); P = .21].

Executive function

Nine RCTs (n = 839) assessed the effects of TCEs on executive function using the TMT. TMT Part B minus Part A (B-A) was used to evaluate task-switching ability, a subdomain of executive function [27]. Smaller difference scores indicate better switching ability. Meta-analysis showed that TCEs were associated with a significant decrease in TMT (B-A) scores [MD = −7.96; 95% CI: (−15.34, −0.59); P = .03; Figure 3a], indicating improved task-switching ability compared to the control group. Heterogeneity between studies was medium (P = .06; I2 = 47%). Subgroup analyses based on the characteristics of the control group revealed a significant difference between the TCE intervention group and the active control group [MD = −8.28; 95% CI: (−15.89, −0.68); P = .03], but not between the TCE intervention group and the care-as-usual control group [MD = −13.02; 95% CI: (−38.46, 12.42); P = .32].

Figure 3.

For image description, please refer to the figure legend and surrounding text.

Forest plot of executive function. (a) Trail Making Test (TMT) (b-a); (b) Category Fluency for Animals.

Three RCTs (n = 588) evaluated the effect of Tai Chi on executive function using the Category Fluency for Animals [28]. Meta-analysis showed a significant improvement in Category Fluency for Animals in the Tai Chi group compared to the control group [MD = 2.96; 95% CI (2.08, 3.85); P < .00001; Figure 3b] with no heterogeneity between studies (P = .42; I2 = 0%).

Working memory

Five RCTs (n = 696) reported the effects of TCEs training on working memory using DS-B. DS-B was used to measure working memory by repeating the sequence verbally in the reverse order (backward) of numerical digits [29]. The pooled analysis of DS-B indicated a significant benefit of TCEs on working memory [MD = 0.48; 95% CI: (0.07, 0.90); P = .02; Figure 4a] with medium heterogeneity between studies (P = .10; I2 = 49%). Subgroup analyses showed a significant difference between the TCE group and the active control group [MD = 0.57; 95% CI: (0.05, 1.08); P = .007], but not between the TCE group and the care-as-usual control group [MD = 0.11; 95% CI: (−0.67, 0.89); P = .78].

Figure 4.

For image description, please refer to the figure legend and surrounding text.

Forest plot of working memory, processing speed, attention and visuospatial ability. (a) Digit Span-Backwards (DS-B); (b) Digit Symbol Coding (DSC); (c) Digit Span-Forwards (DS-F); (d) Clock Drawing Task (CDT).

Processing speed

Three RCTs (n = 302) presented outcomes for processing speed using the DSC, in which participant was required to convert numbers into corresponding symbols as soon as possible in 90 s [30]. Meta-analysis showed that the TCE group had faster processing speed than the control group [MD = 4.16; 95% CI: (1.82, 6.50); P = .0005; Figure 4b] with no heterogeneity among studies (P = .50; I2 = 0%).

Attention

Four RCTs (n = 648) assessed the effects of TCEs training on attention via the DS-F. DS-B was used to measure attention by repeating the sequence verbally in the same order (forward) of numerical digits [29]. The pooled analysis revealed no significant difference between the TCE group and the control group [MD = 0.48; 95% CI: (−0.34, 1.30); P = .25; Figure 4c], and high heterogeneity was detected between studies (P = .0001; I2 = 85%). Subgroup analyses showed no significant differences between the TCE group and either the active control group [MD = 0.75; 95% CI: (−0.23, 1.73); P = .14] or the care-as-usual control group [MD = −0.32; 95% CI: (−1.10, 0.46); P = .42].

Visuospatial ability

Two RCTs (n = 65) assessed the effects of TCE training on visuospatial ability using CDT [31]. Pooled analysis indicated no significant difference between the TCE group and the control group [MD = −0.03; 95% CI: (−0.42, 0.36); P = .88; Figure 4d]. The level of heterogeneity between studies was low (P = .25; I2 = 25%).

Memory function

Four studies (n = 310) measured memory function using the MQ test [32]. Meta-analysis showed that TCE trainings had a significant positive effect on memory function [MD = 13.13; 95% CI: (4.06, 22.20); P = .005; Figure 5a], but there was high heterogeneity between studies (P < .0001; I2 = 87%). Subgroup analyses revealed that the TCEs group performed better than both the active control group [MD = 9.21; 95% CI: (1.71, 16.71); P = .02] and the care-as-usual control group [MD = 14.53; 95% CI: (1.76, 27.31); P = .03].

Figure 5.

For image description, please refer to the figure legend and surrounding text.

Forest plot of memory function. (a) Memory Quotient (MQ); (b) immediate recall of Auditory Verbal Learning Test (AVLT); (c) short-term delayed recognition of AVLT; (d) long-term delayed recognition of AVLT.

Six studies reported the effects of TCEs on verbal memory measured using AVLT [33], including immediate recall in 181 participants, short-term delayed recognition in 833 participants, and long-term delayed recognition in 180 participants. TCE trainings improved verbal memory as shown by enhanced immediate recall [MD = 1.13; 95% CI: (0.07, 2.20); P = .04] with low heterogeneity (P = .25; I2 = 29%) (Figure 5b), short-term delayed recognition [MD = 0.80; 95% CI: (0.28, 1.32); P = .003] with low heterogeneity (P = .31; I2 = 16%) (Figure 5c) and long-term delayed recognition [MD = 1.38; 95% CI: (0.68, 2.09); P = .0001] with no heterogeneity (P = .58; I2 = 0%) (Figure 5d). Subgroup analyses for the AVLT immediate recall subtest showed no significant difference between the TCEs group and the active control group [MD = 1.02; 95% CI: (−0.23, 2.27); P = .11].

All meta-analyses were conducted using random-effects models. The between-study variance (τ2) and 95% prediction intervals for each outcome are provided in Appendix S4.

Sensitivity analyses

While the majority of pooled effect size remained stable, alteration of group effect sizes was observed in several domains. For the DS-F outcome, omitting Li et al., 2023 [29] reduced heterogeneity to I2 = 37%, compared to original analysis (I2 = 85%). Effect size of Digit Symbol Coding task (DSC) outcome, after omitting Chen et al., 2023 [19], reduced significantly [MD = 3.71; 95% CI: (−0.77, 8.20)], of which was no longer significant (P = .10). For the MQ outcome, omitting Tao et al., 2017 [34] eliminated heterogeneity (I2 = 0%), compared to original analysis (I2 = 85%). For the AVLT, omitting Zheng et al., 2020 [35] resulted in a non-significant effect for immediate recall (P = .18), and omitting Su et al., 2021 [36] led to moderate heterogeneity (I2 = 63%) for immediate recall.

These findings suggest that the results for some cognitive outcomes, particularly DS-F, DSC, MQ and AVLT, may be influenced by the inclusion of specific studies. The observed changes in statistical difference and heterogeneity could be related to the number of included studies and the sample sizes. Details of the sensitivity analyses are presented in Appendix S5.

Meta-regression analysis and publication bias

The meta- regression analysis, with 13 studies, revealed no significant effect of any of these variables on the MoCA scores except the covariate of type of TCE (Appendix S6), which suggested the type of TCE was the potential source of heterogeneity.

Publication bias was assessed for the MoCA outcome, which had a sufficient number of studies (n ≥ 10) for this analysis. Visual inspection of the funnel plot for MoCA indicated the presence of slight publication bias. However, Egger’s test did not detect statistically significant publication bias by (P = .231). Funnel plots of cognitive outcomes are presented in Appendix S7.

Discussion

This meta-analysis of 28 RCTs, comprising 2297 participants, evaluated the effects of various types of TCE interventions on global cognition and several cognitive domains in older adults. Extending prior work [37], it includes a wider range of neuropsychological assessments and a more extensive literature search in adults ≥60 years. TCE training significantly improved global cognition, executive function, working memory, processing speed and memory, but not attention or visuospatial ability. Overall, preliminary to moderate evidence supports TCE as a promising strategy for cognitive enhancement in older adults, though methodological limitations and heterogeneity warrant confirmation in high-quality RCTs.

Cognitive decline is a key age-related change, commonly assessed using brief global cognition tests [38], such as the MoCA and the MMSE [39]. The MoCA is generally more sensitive to mild impairment, whereas the MMSE may show ceiling effects. Our pooled analysis revealed that TCEs significantly improved both MoCA and MMSE scores, suggesting potential benefit against global cognitive decline. The type of TCE was identified as a potential factor of heterogeneity in meta-regression, though subgroup analysis found no significant difference between subtypes—likely due to uneven study distribution rather than absence of effect. Additionally, greater MMSE improvement was observed with care-as-usual versus active control, a finding warranting further investigation.

Cognitive performance is commonly assessed using distinct domains in clinical neuropsychology [40]. Individual neuropsychological tests, categorised under different subdomains, can measure one or more discrete cognitive functions [41]. This meta-analysis examined six domains: executive function, working memory, processing speed, attention, memory function and visuospatial ability. TCEs training effectively improved most domains, except attention and visuospatial ability, which may be attributed to significant heterogeneity and the limited number of studies (four or fewer) included in the analyses. From a clinical perspective, subdomain changes are less clinically meaningful but may offer early insights and guide future research, and researchers should exercise caution when interpreting subdomain results.

Executive function, a multidimensional goal-directed system [42], is among the most complex cognitive processes, encompassing reasoning, problem solving, planning and other high-level activities [43]. This study demonstrated that TCE training positively impacts executive function. Notably, a significant study by Lin et al. [44] specifically evaluated the effects of exercise interventions on subdomains of executive function in older adults. This research provides valuable insights and paving the way for further systematic investigations into the role of TCEs in enhancing executive function and overall cognitive health.

This meta-analysis encompassing 28 RCTs with 2297 participants, provides an updated synthesis on TCE effects on cognitive function in adults aged 60 years and older. TCEs positively impact global cognition, executive function, working memory, processing speed and memory. Professional supervision is important to ensure correct technique and adherence. Future research should explore integration with other interventions (e.g. cognitive training, lifestyle programs). Compared to conventional exercise, TCEs offer practical advantages due to their low-impact nature and integration of movement, attention and breathing, which may support engagement for older adults. Simplified TCE protocols for older adults with cognitive impairment are also recommended. The pooled MD of 1.67 points on the MoCA approaches the Minimal Clinically Important Difference (MCID) (1.2–2.0 points) for older adults with mild cognitive impairment [45], suggesting potential clinical relevance in some subgroups, though MCID thresholds vary. Follow-up analyses were precluded by heterogeneity and limited studies, highlighting a gap for future research.

Limitations of this study needs to be mentioned. It focused exclusively on cognition-related outcomes; incorporating other frailty-related indicators (e.g. quality of life, fear of falling) could provide a more holistic perspective. We deviated from the PROSPERO protocol (≥50 vs. ≥60) to improve clinical homogeneity given the observed age heterogeneity across studies. The lack of reported adverse events and long-term follow-up data limits conclusions on safety and sustained effects of TCE training. High attrition rates and inadequate handling of missing data may compromise the validity of the estimated intervention effect. Heterogeneity due to variations in exercise interventions, assessment tools and health conditions of participants persisted despite subgroup analyses and meta-regressions were conducted. Future studies should prespecify subgroup analyses to avoid the risk of over-interpretation or bias. Finally, consistent with findings from a bibliometric analysis [46], most included studies were conducted by Chinese researchers, highlighting the need for more diverse geographic and ethnic representation.

Conclusions

In conclusion, this study underscores the potential of TCEs as an effective, culturally rooted non-pharmacological intervention for improving cognitive function in older adults. The findings highlight promising benefits across various cognitive domains. To advance the field, future research should investigate long-term safety, effectiveness in diverse populations and integration with other interventions. Developing accessible, simplified TCE routines could further support healthy ageing worldwide.

Supplementary Material

aa-25-1236-File002_afag168

Contributor Information

Bin Li, Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan, China.

Lirong Yu, School of Nursing, Shandong Second Medical University, Weifang, Shandong, China.

Na Li, Laboratory of Molecular Pharmacology, Jilin Provincial Key Laboratory of Biomacromolecules of Chinese Medicine, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, China.

Kaisy Xinhong Ye, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Jiuyu Guo, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore.

Luwen Cao, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Jiatong Shan, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Yecheng Li, College of Chemistry, Jilin University, Changchun, China.

Xiu Wang, Department of Neurology, Beijing Chuiyangliu Hospital, Beijing, China.

Tih-Shih Lee, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Neuroscience & Behavioural Disorders Programme, Singapore, Singapore.

Brian K Kennedy, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

John Suckling, Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK.

Andrea Maier, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Human Movement Sciences, Faculty of Behavioral and Movement Sciences, Amsterdam, Netherlands.

Wenbin Wu, Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan, China.

Lei Feng, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Declaration of Conflicts of Interest

None declared.

Declaration of Sources of Funding

National Medical Research Council of Singapore (NMRC/TA/0053/2016, NMRC/CSA/INV/0009/2022), Natural Science Foundation of Sichuan Province (25NSFSC0782), Sichuan Cadre Health Research Project (CGY-2022-504). None of the institutions listed had a role in the preparation or production, and the contents are solely the responsibility of the authors.

Key points

  • Traditional Chinese exercises (TCEs) have a positive impact on cognitive function in adults aged 60 years and older.

  • This meta-analysis showed that TCEs significantly improved global cognition, as well as several specific cognitive domains (executive function, working memory, processing speed and memory) in older adults, with or without other chronic diseases.

  • Future research should evaluate long-term cognitive effects (>6 months), safety and adherence in frail older adults, functional outcomes and quality of life, and conduct large-scale RCTs in underrepresented groups (e.g. MCI, low education, diverse backgrounds).

References

  • 1. World Health Organization . Ageing and Health, 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.
  • 2. Murman  DL. The impact of age on cognition. Semin Hear  2015;36:111–21. 10.1055/s-0035-1555115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. World Health Organization . Dementia, 2021. Available from: https://www.who.int/news-room/facts-in-pictures/detail/dementia.
  • 4. Alzheimer’s Disease International . World Alzheimer Report 2023, 2023. Available from: https://www.alzint.org/resource/world-alzheimer-report-2023/.
  • 5. Chou  YH, Sundman  M, Ton That  V  et al.  Cortical excitability and plasticity in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis of transcranial magnetic stimulation studies. Ageing Res Rev  2022;79:101660. 10.1016/j.arr.2022.101660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6. Li  B, Li  J, Hao  Y  et al.  Yuanzhi powder inhibits tau pathology in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer’s disease. J Ethnopharmacol  2023;311:116393. 10.1016/j.jep.2023.116393. [DOI] [PubMed] [Google Scholar]
  • 7. Kantarci  K, Weigand  SD, Przybelski  SA  et al.  Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS. Neurology  2009;72:1519–25. 10.1212/WNL.0b013e3181a2e864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8. Ding  Z, Leung  PY, Lee  TL  et al.  Effectiveness of lifestyle medicine on cognitive functions in mild cognitive impairments and dementia: a systematic review on randomized controlled trials. Ageing Res Rev  2023;86:101886. 10.1016/j.arr.2023.101886. [DOI] [PubMed] [Google Scholar]
  • 9. Ho  RTH, Fong  TCT, Chan  WC  et al.  Psychophysiological effects of dance movement therapy and physical exercise on older adults with mild dementia: a randomized controlled trial. J Gerontol B Psychol Sci Soc Sci  2020;75:560–70. [DOI] [PubMed] [Google Scholar]
  • 10. Livingston  G, Huntley  J, Liu  KY  et al.  Dementia prevention, intervention, and care: 2024 report of the Lancet standing commission. Lancet  2024;404:572–628. 10.1016/S0140-6736(24)01296-0. [DOI] [PubMed] [Google Scholar]
  • 11. Kivipelto  M, Solomon  A, Ahtiluoto  S  et al.  The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimers Dement  2013;9:657–65. 10.1016/j.jalz.2012.09.012. [DOI] [PubMed] [Google Scholar]
  • 12. Zhang  M, Jia  J, Yang  Y  et al.  Effects of exercise interventions on cognitive functions in healthy populations: a systematic review and meta-analysis. Ageing Res Rev  2023;92:102116. 10.1016/j.arr.2023.102116. [DOI] [PubMed] [Google Scholar]
  • 13. Guo  Y, Shi  H, Yu  D  et al.  Health benefits of traditional Chinese sports and physical activity for older adults: a systematic review of evidence. J Sport Health Sci  2016;5:270–80. 10.1016/j.jshs.2016.07.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14. Lan  C, Lai  JS, Chen  SY. Tai Chi Chuan: an ancient wisdom on exercise and health promotion. Sports Med  2002;32:217–24. 10.2165/00007256-200232040-00001. [DOI] [PubMed] [Google Scholar]
  • 15. Koh  TC. Baduanjin -- an ancient Chinese exercise. Am J Chin Med  1982;10:14–21. 10.1142/S0192415X8200004X. [DOI] [PubMed] [Google Scholar]
  • 16. Cheng  ZJ, Zhang  SP, Gu  YJ  et al.  Effectiveness of Tuina therapy combined with Yijinjing exercise in the treatment of nonspecific chronic neck pain: a randomized clinical trial. JAMA Netw Open  2022;5:e2246538. 10.1001/jamanetworkopen.2022.46538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Luo  SS, Chen  L, Wang  GB  et al.  Effects of long-term Wuqinxi exercise on working memory in older adults with mild cognitive impairment. Eur Geriatr Med  2022;13:1327–33. 10.1007/s41999-022-00709-2. [DOI] [PubMed] [Google Scholar]
  • 18. Qingguang  Z, Shuaipan  Z, Jingxian  LI  et al.  Effectiveness of Liu-zi-jue exercise on coronavirus disease 2019 in the patients: a randomized controlled trial. J Tradit Chin Med  2022;42:997–10053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19. Chen  Y, Qin  J, Tao  L  et al.  Effects of Tai Chi Chuan on cognitive function in adults 60 years or older with type 2 diabetes and mild cognitive impairment in China: a randomized clinical trial. JAMA Netw Open  2023;6:e237004. 10.1001/jamanetworkopen.2023.7004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20. Lin  H, Ye  Y, Wan  M  et al.  Effect of Baduanjin exercise on cerebral blood flow and cognitive frailty in the community older adults with cognitive frailty: a randomized controlled trial. J Exerc Sci Fit  2023;21:131–7. 10.1016/j.jesf.2022.12.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21. Jiang  B, Feng  C, Hu  H  et al.  Traditional Chinese exercise for neurodegenerative diseases: a bibliometric and visualized analysis with future directions. Front Aging Neurosci  2022;14:932924. 10.3389/fnagi.2022.932924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22. Page  MJ, McKenzie  JE, Bossuyt  PM  et al.  The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ  2021;372:n71. 10.1136/bmj.n71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23. Huang  CY, Mayer  PK, Wu  MY  et al.  The effect of tai chi in elderly individuals with sarcopenia and frailty: a systematic review and meta-analysis of randomized controlled trials. Ageing Res Rev  2022;82:101747. 10.1016/j.arr.2022.101747. [DOI] [PubMed] [Google Scholar]
  • 24. Egger  M, Davey Smith  G, Schneider  M  et al.  Bias in meta-analysis detected by a simple, graphical test. BMJ  1997;315:629–34. 10.1136/bmj.315.7109.629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25. Nasreddine  ZS, Phillips  NA, Bedirian  V  et al.  The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc  2005;53:695–9. 10.1111/j.1532-5415.2005.53221.x. [DOI] [PubMed] [Google Scholar]
  • 26. Friedman  TW, Yelland  GW, Robinson  SR. Subtle cognitive impairment in elders with mini-mental state examination scores within the ‘normal’ range. Int J Geriatr Psychiatry  2012;27:463–71. 10.1002/gps.2736. [DOI] [PubMed] [Google Scholar]
  • 27. Miyake  A, Friedman  NP, Emerson  MJ  et al.  The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cogn Psychol  2000;41:49–100. 10.1006/cogp.1999.0734. [DOI] [PubMed] [Google Scholar]
  • 28. Sager  MA, Hermann  BP, La Rue  A  et al.  Screening for dementia in community-based memory clinics. WMJ  2006;105:25–9. [PubMed] [Google Scholar]
  • 29. Li  F, Harmer  P, Eckstrom  E  et al.  Clinical effectiveness of cognitively enhanced tai Ji Quan training on global cognition and dual-task performance during walking in older adults with mild cognitive impairment or self-reported memory concerns: a randomized controlled trial. Ann Intern Med  2023;176:1498–507. 10.7326/M23-1603. [DOI] [PubMed] [Google Scholar]
  • 30. Charles  LE, Fekedulegn  D, Burchfiel  CM  et al.  Work hours and cognitive function: the multi-ethnic study of atherosclerosis. Saf Health Work  2020;11:178–86. 10.1016/j.shaw.2020.02.004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31. Srivastava  H, Joop  A, Memon  RA  et al.  Taking the time to assess cognition in Parkinson’s disease: the clock drawing test. J Parkinsons Dis  2022;12:713–22. 10.3233/JPD-212802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32. Elwood  RW. The Wechsler memory scale-revised: psychometric characteristics and clinical application. Neuropsychol Rev  1991;2:179–201. 10.1007/BF01109053. [DOI] [PubMed] [Google Scholar]
  • 33. Rosenberg  SJ, Ryan  JJ, Prifitera  A. Rey auditory-verbal learning test performance of patients with and without memory impairment. J Clin Psychol  1984;40:785–7. 10.1002/1097-4679(198405)40:3<785::AID-JCLP2270400325>3.0.CO;2-4. [DOI] [PubMed] [Google Scholar]
  • 34. Tao  J, Chen  X, Egorova  N  et al.  Tai Chi Chuan and Baduanjin practice modulates functional connectivity of the cognitive control network in older adults. Sci Rep  2017;7:41581. 10.1038/srep41581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35. Zheng  G, Zheng  Y, Xiong  Z  et al.  Effect of Baduanjin exercise on cognitive function in patients with post-stroke cognitive impairment: a randomized controlled trial. Clin Rehabil  2020;34:1028–39. 10.1177/0269215520930256. [DOI] [PubMed] [Google Scholar]
  • 36. Su  H, Wang  H, Meng  L  et al.  The effects of Baduanjin exercise on the subjective memory complaint of older adults: a randomized controlled trial. Medicine (United States)  2021;100:E25442. 10.1097/MD.0000000000025442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37. Yao  KR, Luo  Q, Tang  X  et al.  Effects of traditional Chinese mind-body exercises on older adults with cognitive impairment: a systematic review and meta-analysis. Front Neurol  2023;14:1086417. 10.3389/fneur.2023.1086417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38. Arevalo-Rodriguez  I, Smailagic  N, Roque-Figuls  M  et al.  Mini-mental state examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev  2021;2021:CD010783. 10.1002/14651858.CD010783.pub3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39. Riello  M, Rusconi  E, Treccani  B. The role of brief global cognitive tests and neuropsychological expertise in the detection and differential diagnosis of dementia. Front Aging Neurosci  2021;13:648310. 10.3389/fnagi.2021.648310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40. Harvey  PD. Domains of cognition and their assessment. Dialogues Clin Neurosci  2019;21:227–37. 10.31887/DCNS.2019.21.3/pharvey. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41. Lezak  MD, Howieson  DB, Bigler  ED  et al.  Neuropsychological Assessment. 5th edition. New York, NY, US: Oxford University Press, 2012. [Google Scholar]
  • 42. Goldberg  TE, Weinberger  DR. Probing prefrontal function in schizophrenia with neuropsychological paradigms. Schizophr Bull  1988;14:179–83. 10.1093/schbul/14.2.179. [DOI] [PubMed] [Google Scholar]
  • 43. Al-Aidroos  N, Said  CP, Turk-Browne  NB. Top-down attention switches coupling between low-level and high-level areas of human visual cortex. Proc Natl Acad Sci U S A  2012;109:14675–80. 10.1073/pnas.1202095109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 44. Lin  M, Ma  C, Zhu  J  et al.  Effects of exercise interventions on executive function in old adults with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials. Ageing Res Rev  2022;82:101776. 10.1016/j.arr.2022.101776. [DOI] [PubMed] [Google Scholar]
  • 45. Lindvall  E, Abzhandadze  T, Quinn  TJ  et al.  Is the difference real, is the difference relevant: the minimal detectable and clinically important changes in the Montreal cognitive assessment. Cereb Circ Cogn Behav  2024;6:100222. 10.1016/j.cccb.2024.100222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 46. Zhang  J, Yang  Z, Fan  H. Knowledge structure and future research trends of body-mind exercise for mild cognitive impairment: a bibliometric analysis. Front Neurol  2024;15:1351741. 10.3389/fneur.2024.1351741. [DOI] [PMC free article] [PubMed] [Google Scholar]

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