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[Preprint]. 2026 Jun 2:2026.05.29.728772. [Version 1] doi: 10.64898/2026.05.29.728772

Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments

Pooja R Solanke, Debolina Sarkar, Pranab C Saha, Michael T Taylor
PMCID: PMC13252017  PMID: 42282783

Abstract

We report here a method for the chemical synthesis of Fmoc-protected α-hydroxyglyine (α-OH-Gly) dipeptides. Our method features operational simplicity and is compatible with protecting groups for peptide synthesis. Utility is then demonstrated through substitution at the α-OH-Gly position to yield myriad non-natural amino acid-containing dipeptide fragments.

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