Xiaomin Wang
Xiaomin Wang
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
3
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Writing–review and editing, Conceptualization, Investigation, Writing–original draft, Software, Formal Analysis, Visualization
1,2,3,†,
Yuhang Ding
Yuhang Ding
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Writing–original draft, Writing–review and editing, Validation, Software, Formal Analysis, Investigation
1,2,†,
Yunxiao Mai
Yunxiao Mai
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Writing–review and editing, Methodology, Investigation, Software
1,2,†,
Ruinan Li
Ruinan Li
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Validation, Methodology, Formal Analysis, Writing–review and editing, Investigation
1,
Xinyu Shao
Xinyu Shao
3
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
4
Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, China
Writing–review and editing, Methodology, Visualization
3,4,
Wenlong Chen
Wenlong Chen
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Software, Project administration, Writing–review and editing, Investigation
1,2,
Yiming Li
Yiming Li
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Methodology, Writing–review and editing, Validation
1,2,
Luhaoxiang Liu
Luhaoxiang Liu
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Writing–review and editing, Resources, Investigation, Methodology
1,2,
Haoran Wang
Haoran Wang
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Data curation, Writing–review and editing, Resources
1,2,
Kangkang Liu
Kangkang Liu
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Writing–review and editing, Methodology, Project administration, Funding acquisition
2,
Yuanjie Niu
Yuanjie Niu
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
5
Haihe Laboratory of Synthetic Biology, Tianjin, China
Project administration, Writing–review and editing, Funding acquisition
2,5,
Jianmin Li
Jianmin Li
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Project administration, Supervision, Data curation, Writing–review and editing
2,
Guoping Xu
Guoping Xu
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Visualization, Project administration, Supervision, Data curation, Conceptualization, Writing–review and editing
1,*,
Yang Zhao
Yang Zhao
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
Writing–review and editing, Supervision, Conceptualization, Project administration
1,2,*
1
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
2
Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China
3
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
4
Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, China
5
Haihe Laboratory of Synthetic Biology, Tianjin, China
*
Correspondence: Yang Zhao, yang.zhao@tmu.edu.cn; Guoping Xu, doctorxu312@126.com
†These authors have contributed equally to this work
Roles
Xiaomin Wang: Writing–review and editing, Conceptualization, Investigation, Writing–original draft, Software, Formal Analysis, Visualization
Yuhang Ding: Writing–original draft, Writing–review and editing, Validation, Software, Formal Analysis, Investigation
Yunxiao Mai: Writing–review and editing, Methodology, Investigation, Software
Ruinan Li: Validation, Methodology, Formal Analysis, Writing–review and editing, Investigation
Xinyu Shao: Writing–review and editing, Methodology, Visualization
Wenlong Chen: Software, Project administration, Writing–review and editing, Investigation
Yiming Li: Methodology, Writing–review and editing, Validation
Luhaoxiang Liu: Writing–review and editing, Resources, Investigation, Methodology
Haoran Wang: Data curation, Writing–review and editing, Resources
Kangkang Liu: Writing–review and editing, Methodology, Project administration, Funding acquisition
Yuanjie Niu: Project administration, Writing–review and editing, Funding acquisition
Jianmin Li: Project administration, Supervision, Data curation, Writing–review and editing
Guoping Xu: Visualization, Project administration, Supervision, Data curation, Conceptualization, Writing–review and editing
Yang Zhao: Writing–review and editing, Supervision, Conceptualization, Project administration
Received 2026 May 15; Accepted 2026 May 26; Collection date 2026.
Keywords: breast cancer, DNA damage, doxorubicin, EZH2, metabolic vulnerability, resistance
Copyright © 2026 Wang, Ding, Mai, Li, Shao, Chen, Li, Liu, Wang, Liu, Niu, Li, Xu and Zhao.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
