Abstract
Hyperpolarizing conditioning pulses delay the onset of potassium channel current in voltage-clamped myelinated nerve fibers. Both the development of and recovery from this conditioning are approximately exponential functions of time: the time constants are functions of the conditioning voltage. The delay is larger and develops faster for more hyperpolarized conditioning pulses. The magnitude of the delay (but not the rate of development or recovery) depends upon the test potential-small test depolarizations produce larger delays than large depolarizations. The currents with and without the conditioning pulse cannot be made to superimpose by a simple time translation.
Full text
PDF








Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Armstrong C. M., Bezanilla F. Charge movement associated with the opening and closing of the activation gates of the Na channels. J Gen Physiol. 1974 May;63(5):533–552. doi: 10.1085/jgp.63.5.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Armstrong C. M., Hille B. The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier. J Gen Physiol. 1972 Apr;59(4):388–400. doi: 10.1085/jgp.59.4.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ehrenstein G., Gilbert D. L. Slow changes of potassium permeability in the squid giant axon. Biophys J. 1966 Sep;6(5):553–566. doi: 10.1016/S0006-3495(66)86677-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRANKENHAEUSER B. A QUANTITATIVE DESCRIPTION OF POTASSIUM CURRENTS IN MYELINATED NERVE FIBRES OF XENOPUS LAEVIS. J Physiol. 1963 Nov;169:424–430. doi: 10.1113/jphysiol.1963.sp007268. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRANKENHAEUSER B. Instantaneous potassium currents in myelinated nerve fibres of Xenopus laevis. J Physiol. 1962 Jan;160:46–53. doi: 10.1113/jphysiol.1962.sp006833. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRANKENHAEUSER B. Potassium permeability in myelinated nerve fibres of Xenopus laevis. J Physiol. 1962 Jan;160:54–61. doi: 10.1113/jphysiol.1962.sp006834. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldman L., Binstock L. Current separations in Myxicola giant axons. J Gen Physiol. 1969 Dec;54(6):741–754. doi: 10.1085/jgp.54.6.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldman L., Schauf C. L. Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons. J Gen Physiol. 1973 Mar;61(3):361–384. doi: 10.1085/jgp.61.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544. doi: 10.1113/jphysiol.1952.sp004764. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J Physiol. 1952 Apr;116(4):449–472. doi: 10.1113/jphysiol.1952.sp004717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill T. L., Chen Y. D. On the theory of ion transport across the nerve membrane. 3. Potassium ion kinetics and cooperativity (with x=4,6,9). Proc Natl Acad Sci U S A. 1971 Oct;68(10):2488–2492. doi: 10.1073/pnas.68.10.2488. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill T. L., Chen Y. D. On the theory of ion transport across the nerve membrane. II. Potassium ion kinetics and cooperativity (with x = 4). Proc Natl Acad Sci U S A. 1971 Aug;68(8):1711–1715. doi: 10.1073/pnas.68.8.1711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hille B. The permeability of the sodium channel to organic cations in myelinated nerve. J Gen Physiol. 1971 Dec;58(6):599–619. doi: 10.1085/jgp.58.6.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keynes R. D., Rojas E. The temporal and steady-state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon. J Physiol. 1976 Feb;255(1):157–189. doi: 10.1113/jphysiol.1976.sp011274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moore L. E. Effect of temperature and calcium ions on rate constants of myelinated nerve. Am J Physiol. 1971 Jul;221(1):131–137. doi: 10.1152/ajplegacy.1971.221.1.131. [DOI] [PubMed] [Google Scholar]
- Palti Y., Ganot G., Stämpfli R. Effect of conditioning potential on potassium current kinetics in the frog node. Biophys J. 1976 Mar;16(3):261–273. doi: 10.1016/S0006-3495(76)85686-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shrager P. Ionic conductance changes in voltage clamped crayfish axons at low pH. J Gen Physiol. 1974 Dec;64(6):666–690. doi: 10.1085/jgp.64.6.666. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodhull A. M. Ionic blockage of sodium channels in nerve. J Gen Physiol. 1973 Jun;61(6):687–708. doi: 10.1085/jgp.61.6.687. [DOI] [PMC free article] [PubMed] [Google Scholar]