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. 1979 Sep;27(3):455–460. doi: 10.1016/S0006-3495(79)85229-7

Light-scattering studies of the monomer-dimer states of gramicidin A.

F Rondelez, J D Litster
PMCID: PMC1328600  PMID: 95568

Abstract

Measurements of the intensity and autocorrelation function of ligh quasielastically scattered by gramicidin A indicate that the molecules exist as dimers in methanol and dioxane and monomers in dimethyl sulfoxide when solute concentrations range from 18 to 50 mg/ml. This gives further evidence that gramicidin A can dimerize in low-polarity media such as the hydrocarbon part of the membrane bilayers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bamberg E., Läuger P. Channel formation kinetics of gramicidin A in lipid bilayer membranes. J Membr Biol. 1973;11(2):177–194. doi: 10.1007/BF01869820. [DOI] [PubMed] [Google Scholar]
  2. Dubin S. B., Lunacek J. H., Benedek G. B. Observation of the spectrum of light scattered by solutions of biological macromolecules. Proc Natl Acad Sci U S A. 1967 May;57(5):1164–1171. doi: 10.1073/pnas.57.5.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Glickson J. D., Mayers D. F., Settine J. M., Urry D. W. Spectroscopic studies on the conformation of gramicidin A'. Proton magnetic resonance assignments, coupling constants, and H-D exchange. Biochemistry. 1972 Feb 15;11(4):477–486. doi: 10.1021/bi00754a001. [DOI] [PubMed] [Google Scholar]
  4. Mueller P., Rudin D. O. Development of K+-Na+ discrimination in experimental bimolecular lipid membranes by macrocyclic antibiotics. Biochem Biophys Res Commun. 1967 Feb 21;26(4):398–404. doi: 10.1016/0006-291x(67)90559-1. [DOI] [PubMed] [Google Scholar]
  5. Podleski T., Changeux J. P. Effects associated with permeability changes caused by gramicidin A in electroplax membrane. Nature. 1969 Feb 8;221(5180):541–545. doi: 10.1038/221541a0. [DOI] [PubMed] [Google Scholar]
  6. Rothschild K. J., Stanley H. E. Raman spectroscopic investigation of gramicidin A' conformations. Science. 1974 Aug 16;185(4151):616–618. doi: 10.1126/science.185.4151.616. [DOI] [PubMed] [Google Scholar]
  7. SARGES R., WITKOP B. GRAMICIDIN A. V. THE STRUCTURE OF VALINE- AND ISOLEUCINE-GRAMICIDIN A. J Am Chem Soc. 1965 May 5;87:2011–2020. doi: 10.1021/ja01087a027. [DOI] [PubMed] [Google Scholar]
  8. Urry D. W., Goodall M. C., Glickson J. D., Mayers D. F. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907–1911. doi: 10.1073/pnas.68.8.1907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Urry D. W. The gramicidin A transmembrane channel: a proposed pi(L,D) helix. Proc Natl Acad Sci U S A. 1971 Mar;68(3):672–676. doi: 10.1073/pnas.68.3.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Veatch W. R., Blout E. R. The aggregation of gramicidin A in solution. Biochemistry. 1974 Dec 17;13(26):5257–5264. doi: 10.1021/bi00723a002. [DOI] [PubMed] [Google Scholar]
  11. Veatch W. R., Fossel E. T., Blout E. R. The conformation of gramicidin A. Biochemistry. 1974 Dec 17;13(26):5249–5256. doi: 10.1021/bi00723a001. [DOI] [PubMed] [Google Scholar]

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