Abstract
The plaque development of Herpes simplex virus type 1 (HSV) is slower for viruses treated with two anti-DNA agents: ultraviolet radiation (UV) or n-acetoxy-2-acetyl-aminofluorene. For HSV treated with three antimembrane agents--butylated hydroxytoluene, acridine plus near UV radiation, or ether--the plaque development time is the same as for untreated viruses. These differences hold even for viruses that survived treatment that lowered viability below the 1% level. Gamma ray inactivation of HSV produces no change in plaque development even though this agent is believed to preferentially affect viral DNA.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cameron K. R. Ultraviolet irradiation of herpes simplex virus: action spectrum for the survival of infectivity in relation to the small-plaque effect. J Gen Virol. 1973 Jan;18(1):51–54. doi: 10.1099/0022-1317-18-1-51. [DOI] [PubMed] [Google Scholar]
- Coohill T. P., James L. C., Moore S. P. The wavelength dependence of ultraviolet enhanced reactivation in a mammalian cell-virus system. Photochem Photobiol. 1978 Jun;27(6):725–730. doi: 10.1111/j.1751-1097.1978.tb07670.x. [DOI] [PubMed] [Google Scholar]
- HOGGAN M. D., ROIZMAN B. The isolation and properties of a variant of Herpes simplex producing multinucleated giant cells in monolayer cultures in the presence of antibody. Am J Hyg. 1959 Sep;70:208–219. doi: 10.1093/oxfordjournals.aje.a120071. [DOI] [PubMed] [Google Scholar]
- POWELL W. F. Radiosensitivity as an index of herpes simplex virus development. Virology. 1959 Sep;9:1–19. doi: 10.1016/0042-6822(59)90096-0. [DOI] [PubMed] [Google Scholar]
- Ross L. J., Cameron K. R., Wildy P. Ultraviolet irradiation of herpes simplex virus: reactivation processes and delay in virus multiplication. J Gen Virol. 1972 Sep;16(3):299–311. doi: 10.1099/0022-1317-16-3-299. [DOI] [PubMed] [Google Scholar]
- Ross L. J., Wildy P., Cameron K. R. Formation of small plaques by herpes viruses irradiated with ultraviolet light. Virology. 1971 Sep;45(3):808–812. doi: 10.1016/0042-6822(71)90201-7. [DOI] [PubMed] [Google Scholar]
- Snipes W., Keller G., Woog J., Vickroy T., Deering R., Keith A. Inactivation of lipid-containing viruses by hydrophobic photosensitizers and near-ultraviolet radiation. Photochem Photobiol. 1979 Apr;29(4):785–790. doi: 10.1111/j.1751-1097.1979.tb07767.x. [DOI] [PubMed] [Google Scholar]
- Snipes W., Person S., Keith A., Cupp J. Butylated hydroxytoluene inactivated lipid-containing viruses. Science. 1975 Apr 4;188(4183):64–66. doi: 10.1126/science.163494. [DOI] [PubMed] [Google Scholar]