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. 1982 Nov;40(2):109–120. doi: 10.1016/S0006-3495(82)84465-2

Internal viscoelastic loading in cat papillary muscle.

Y L Chiu, E W Ballou, L E Ford
PMCID: PMC1328983  PMID: 7171707

Abstract

The passive mechanical properties of myocardium were defined by measuring force responses to rapid length ramps applied to unstimulated cat papillary muscles. The immediate force changes following these ramps recovered partially to their initial value, suggesting a series combination of viscous element and spring. Because the stretched muscle can bear force at rest, the viscous element must be in parallel with an additional spring. The instantaneous extension-force curves measured at different lengths were nonlinear, and could be made to superimpose by a simple horizontal shift. This finding suggests that the same spring was being measured at each length, and that this spring was in series with both the viscous element and its parallel spring (Voigt configuration), so that the parallel spring is held nearly rigid by the viscous element during rapid steps. The series spring in the passive muscle could account for most of the series elastic recoil in the active muscle, suggesting that the same spring is in series with both the contractile elements and the viscous element. It is postulated that the viscous element might be coupled to the contractile elements by a compliance, so that the load imposed on the contractile elements by the passive structures is viscoelastic rather than purely viscous. Such a viscoelastic load would give the muscle a length-independent, early diastolic restoring force. The possibility is discussed that the length-independent restoring force would allow some of the energy liberated during active shortening to be stored and released during relaxation.

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116FIGURE 7
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117FIGURE 8
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABBOTT B. C., MOMMAERTS W. F. A study of inotropic mechanisms in the papillary muscle preparation. J Gen Physiol. 1959 Jan 20;42(3):533–551. doi: 10.1085/jgp.42.3.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRECHER G. A. Critical review of recent work on ventricular diastolic suction. Circ Res. 1958 Sep;6(5):554–566. doi: 10.1161/01.res.6.5.554. [DOI] [PubMed] [Google Scholar]
  3. Chiu Y. L., Karwash S., Ford L. E. A piezoelectric force transducer for single muscle cells. Am J Physiol. 1978 Sep;235(3):C143–C146. doi: 10.1152/ajpcell.1978.235.3.C143. [DOI] [PubMed] [Google Scholar]
  4. Civan M. M., Podolsky R. J. Contraction kinetics of striated muscle fibres following quick changes in load. J Physiol. 1966 Jun;184(3):511–534. doi: 10.1113/jphysiol.1966.sp007929. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Donald T. C., Reeves D. N., Reeves R. C., Walker A. A., Hefner L. L. Effect of damaged ends in papillary muscle preparations. Am J Physiol. 1980 Jan;238(1):H14–H23. doi: 10.1152/ajpheart.1980.238.1.H14. [DOI] [PubMed] [Google Scholar]
  6. Ford L. E., Huxley A. F., Simmons R. M. Tension responses to sudden length change in stimulated frog muscle fibres near slack length. J Physiol. 1977 Jul;269(2):441–515. doi: 10.1113/jphysiol.1977.sp011911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ford L. E., Huxley A. F., Simmons R. M. The relation between stiffness and filament overlap in stimulated frog muscle fibres. J Physiol. 1981 Feb;311:219–249. doi: 10.1113/jphysiol.1981.sp013582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Forman R., Ford L. E., Sonnenblick E. H. Effect of muscle length on the force-velocity relationship of tetanized cardiac muscle. Circ Res. 1972 Aug;31(2):195–206. doi: 10.1161/01.res.31.2.195. [DOI] [PubMed] [Google Scholar]
  9. Gilmore J. P., Cingolani H. E., Taylor R. R., McDonald R. H., Jr Physical factors and cardiac adaptation. Am J Physiol. 1966 Nov;211(5):1219–1226. doi: 10.1152/ajplegacy.1966.211.5.1219. [DOI] [PubMed] [Google Scholar]
  10. Gordon A. M., Huxley A. F., Julian F. J. Tension development in highly stretched vertebrate muscle fibres. J Physiol. 1966 May;184(1):143–169. doi: 10.1113/jphysiol.1966.sp007908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hefner L. L., Bowen T. E., Jr Elastic components of cat papillary muscle. Am J Physiol. 1967 May;212(5):1221–1227. doi: 10.1152/ajplegacy.1967.212.5.1221. [DOI] [PubMed] [Google Scholar]
  12. Hill D. K. Tension due to interaction between the sliding filaments in resting striated muscle. The effect of stimulation. J Physiol. 1968 Dec;199(3):637–684. doi: 10.1113/jphysiol.1968.sp008672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Huxley A. F., Simmons R. M. Proposed mechanism of force generation in striated muscle. Nature. 1971 Oct 22;233(5321):533–538. doi: 10.1038/233533a0. [DOI] [PubMed] [Google Scholar]
  14. Janicki J. S., Weber K. T. Ejection pressure and the diastolic left ventricular pressure-volume relation. Am J Physiol. 1977 Jun;232(6):H545–H552. doi: 10.1152/ajpheart.1977.232.6.H545. [DOI] [PubMed] [Google Scholar]
  15. Krueger J. W., Pollack G. H. Myocardial sarcomere dynamics during isometric contraction. J Physiol. 1975 Oct;251(3):627–643. doi: 10.1113/jphysiol.1975.sp011112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Little R. C., Wead W. B. Diastolic viscoelastic properties of active and quiescent cardiac muscle. Am J Physiol. 1971 Oct;221(4):1120–1125. doi: 10.1152/ajplegacy.1971.221.4.1120. [DOI] [PubMed] [Google Scholar]
  17. Nakajima S., Gilai A., Dingeman D. Dye absorption changes in single muscle fibers: an application of an automatic balancing circuit. Pflugers Arch. 1976 Apr 6;362(3):285–287. doi: 10.1007/BF00581183. [DOI] [PubMed] [Google Scholar]
  18. PODOLSKY R. J. Kinetics of muscular contraction: the approach to the steady state. Nature. 1960 Nov 19;188:666–668. doi: 10.1038/188666a0. [DOI] [PubMed] [Google Scholar]
  19. Parmley W. W., Sonnenblick E. H. Series elasticity in heart muscle. Its relation to contractile element velocity and proposed muscle models. Circ Res. 1967 Jan;20(1):112–123. doi: 10.1161/01.res.20.1.112. [DOI] [PubMed] [Google Scholar]
  20. Pinto J. G., Patitucci P. J. Creep in cardiac muscle. Am J Physiol. 1977 Jun;232(6):H553–H563. doi: 10.1152/ajpheart.1977.232.6.H553. [DOI] [PubMed] [Google Scholar]
  21. Pollack G. H. Maximum velocity as an index of contractility in cardiac muscle. A critical evaluation. Circ Res. 1970 Jan;26(1):111–127. doi: 10.1161/01.res.26.1.111. [DOI] [PubMed] [Google Scholar]
  22. Sagawa K. The ventricular pressure-volume diagram revisited. Circ Res. 1978 Nov;43(5):677–687. doi: 10.1161/01.res.43.5.677. [DOI] [PubMed] [Google Scholar]
  23. Tamiya K., Sugawara M., Sakurai Y. Maximum lengthening velocity during isotonic relaxation at preload in canine papillary muscle. Am J Physiol. 1979 Jul;237(1):H83–H89. doi: 10.1152/ajpheart.1979.237.1.H83. [DOI] [PubMed] [Google Scholar]
  24. Weiss J. L., Frederiksen J. W., Weisfeldt M. L. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest. 1976 Sep;58(3):751–760. doi: 10.1172/JCI108522. [DOI] [PMC free article] [PubMed] [Google Scholar]

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