Abstract
Binding features of heroin in whole blood and in blood fractions were delineated by measuring the selective spin-lattice relaxation rates of heroin protons in physiologic conditions. Interaction with some receptor located in the whole human blood or in the human plasma was detected and the apparent binding constant calculated (K = 39 mol-1 dm3). Inferences about molecular dynamics of the bound heroin could be also gained.
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- Comparini I. B., Gaggelli E., Valensin G. Effect of morphine analogues on the conformational state of polyriboadenylic acid in solution: an NMR study. Biophys Chem. 1981 Nov;14(3):217–220. doi: 10.1016/0301-4622(81)85022-3. [DOI] [PubMed] [Google Scholar]
- Lockridge O., Mottershaw-Jackson N., Eckerson H. W., La Du B. N. Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase. J Pharmacol Exp Ther. 1980 Oct;215(1):1–8. [PubMed] [Google Scholar]
- Nakamura G. R., Thornton J. I., Noguchi T. T. Kinetics of heroin deacetylation in aqueous alkaline solution and in human serum and whole blood. J Chromatogr. 1975 Jul 2;110(1):81–89. doi: 10.1016/s0021-9673(00)91213-5. [DOI] [PubMed] [Google Scholar]
- Owen J. A., Nakatsu K. Diacetylmorphine (heroin) hydrolases in human blood. Can J Physiol Pharmacol. 1983 Aug;61(8):870–875. doi: 10.1139/y83-132. [DOI] [PubMed] [Google Scholar]
- Umans J. G., Chiu T. S., Lipman R. A., Schultz M. F., Shin S. U., Inturrisi C. E. Determination of heroin and its metabolites by high-performance liquid chromatography. J Chromatogr. 1982 Dec 10;233:213–225. doi: 10.1016/s0378-4347(00)81748-x. [DOI] [PubMed] [Google Scholar]
- Valensin G., Casini A., Lepri A., Gaggelli E. Conformational features of cell-bound drugs as detected by selective proton relaxation rate investigations. Biophys Chem. 1983 Jun;17(4):297–300. doi: 10.1016/0301-4622(83)80014-3. [DOI] [PubMed] [Google Scholar]
- Valensin P. E., Bianchi-Bandinelli M. L., di Cairano M. L., Gaggelli E., Valensin G. NMR parameters of local anesthetics as biological markers of the cell-virus interactions. Arch Virol. 1985;83(3-4):241–249. doi: 10.1007/BF01309920. [DOI] [PubMed] [Google Scholar]