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. 1985 Aug;48(2):327–329. doi: 10.1016/S0006-3495(85)83786-3

Does Dimeric Melittin Occur in Aqueous Solutions?

D Schubert, G Pappert, K Boss
PMCID: PMC1329324  PMID: 19431595

Abstract

Melittin, a peptide from bee venom, is known to undergo a monomer / tetramer conversion in aqueous solutions. We have studied the possible participation of dimers in the association equilibrium of melittin by sedimentation equilibrium experiments in the analytical ultracentrifuge and subsequent mathematical analysis of the concentration distributions obtained. It was found that the dimeric state is not significantly populated, the contribution of dimer to the total peptide weight probably being below 0.5%.

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Selected References

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