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. 1985 Aug;48(2):349–353. doi: 10.1016/S0006-3495(85)83790-5

Protons decrease the single channel conductance of the sarcoplasmic reticulum K+ channel in neutral and negatively charged bilayers.

J Bell
PMCID: PMC1329328  PMID: 2413916

Abstract

The conductance of rabbit sarcoplasmic reticulum K+ channels incorporated into artificial bilayers of varying lipid composition was measured at different K+ and proton concentrations. Protons competitively inhibit the K+ conductance with a Ki of 0.5 microM. In negatively charged membranes, the conductance is well described by Gouy-Chapman-Stern theory modified to include the inhibitory effect of protons of the conductance and assuming that the channel mouth is isolated by 5-10 A from bilayer surface.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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