Abstract
The glucose-induced B-cell electrical activity was recorded in islets of Langerhans isolated from Swiss Webster albino mice originating from different suppliers. 23 out of 25 islets obtained from mice bred at the Charles River Breeding Station (CR mice) exhibited irregular or chaotic burst patterns of electrical activity, while 36 out of 40 islets isolated from mice bred locally at the National Institutes of Health displayed the typical bursting activity. The CR mice tended to recover a regular pattern after 1 mo on the National Institutes of Health mouse diet. The irregular or chaotic bursting electrical activity is proposed to result from changes in B-cell membrane composition or cellular metabolism, possibly induced by differences in diet.
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