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. 1988 Aug;54(2):309–320. doi: 10.1016/S0006-3495(88)82961-8

The use of dwell time cross-correlation functions to study single-ion channel gating kinetics.

F G Ball 1, C J Kerry 1, R L Ramsey 1, M S Sansom 1, P N Usherwood 1
PMCID: PMC1330298  PMID: 2462924

Abstract

The derivation of cross-correlation functions from single-channel dwell (open and closed) times is described. Simulation of single-channel data for simple gating models, alongside theoretical treatment, is used to demonstrate the relationship of cross-correlation functions to underlying gating mechanisms. It is shown that time irreversibility of gating kinetics may be revealed in cross-correlation functions. Application of cross-correlation function analysis to data derived from the locust muscle glutamate receptor-channel provides evidence for multiple gateway states and time reversibility of gating. A model for the gating of this channel is used to show the effect of omission of brief channel events on cross-correlation functions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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