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. 1988 Nov;54(5):955–960. doi: 10.1016/S0006-3495(88)83031-5

Sequential modification of membrane currents with classical conditioning.

C Collin 1, H Ikeno 1, J F Harrigan 1, I Lederhendler 1, D L Alkon 1
PMCID: PMC1330403  PMID: 2853980

Abstract

Pavlovian conditioning of the nudibranch mollusc Hermissenda crassicornis was previously shown to produce long-lasting reduction of two K+ currents measured across the Type B photoreceptor soma membrane (Alkon et al., 1982a; Alkon et al., 1985). Pavlovian conditioning of the rabbit was also shown to be followed by persistent K+ current reduction (Disterhoft et al., 1986). Here we report the first evidence that Ca2+ currents can also be modified by conditioning. The amplitude of the currents rather than their voltage-dependence remains reduced at least 1-2 d after conditioning (but not control procedures). Conditioning-induced changes of both K+ and Ca2+ currents increased as a function of training, the Ca2+ currents only changing substantially with greater than or equal to 250 trials. The later changes of the Ca2+ current may function to limit the magnitude of excitability increases due to associative learning.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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