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. 1988 Dec;54(6):1165–1168. doi: 10.1016/S0006-3495(88)83051-0

Rate-amplitude correlation from single-channel records. A hidden structure in ion channel gating kinetics?

G L Millhauser 1, E E Salpeter 1, R E Oswald 1
PMCID: PMC1330426  PMID: 2466494

Abstract

Lifetime probability density functions from single-channel recording are usually assumed to follow a multiexponential form. The amplitudes and rate constants for each exponential component are presumed to be independent. We have explored this assumption and have found a correlation between the amplitudes and the rate constants in certain cases. We examine this correlation and the possibility that other functional forms may also properly describe these distribution functions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ansari A., Berendzen J., Bowne S. F., Frauenfelder H., Iben I. E., Sauke T. B., Shyamsunder E., Young R. D. Protein states and proteinquakes. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5000–5004. doi: 10.1073/pnas.82.15.5000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blatz A. L., Magleby K. L. Quantitative description of three modes of activity of fast chloride channels from rat skeletal muscle. J Physiol. 1986 Sep;378:141–174. doi: 10.1113/jphysiol.1986.sp016212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kerry C. J., Ramsey R. L., Sansom M. S., Usherwood P. N. Glutamate receptor channel kinetics: the effect of glutamate concentration. Biophys J. 1988 Jan;53(1):39–52. doi: 10.1016/S0006-3495(88)83064-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Magleby K. L., Pallotta B. S. Calcium dependence of open and shut interval distributions from calcium-activated potassium channels in cultured rat muscle. J Physiol. 1983 Nov;344:585–604. doi: 10.1113/jphysiol.1983.sp014957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Millhauser G. L., Oswald R. E. A reevaluation of the mathematical models for simulating single-channel and whole-cell ionic currents. Synapse. 1988;2(1):97–103. doi: 10.1002/syn.890020113. [DOI] [PubMed] [Google Scholar]
  6. Millhauser G. L., Salpeter E. E., Oswald R. E. Diffusion models of ion-channel gating and the origin of power-law distributions from single-channel recording. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1503–1507. doi: 10.1073/pnas.85.5.1503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sine S. M., Steinbach J. H. Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist. J Physiol. 1987 Apr;385:325–359. doi: 10.1113/jphysiol.1987.sp016496. [DOI] [PMC free article] [PubMed] [Google Scholar]

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