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. 1989 Jun;55(6):1267–1271. doi: 10.1016/S0006-3495(89)82922-4

Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.

M Pusch 1, F Conti 1, W Stühmer 1
PMCID: PMC1330591  PMID: 2548634

Abstract

Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.

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Selected References

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