Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1975 Mar;245(3):567–582. doi: 10.1113/jphysiol.1975.sp010862

Aspects of bile secretion in the rabbit.

S C Rutishauser, S L Stone
PMCID: PMC1330806  PMID: 1142218

Abstract

1. Bile secretion was studied in anaesthetized rabbits from whom hepatic bile was collected by cannulation of the common bile duct. 2. The flow and composition of bile formed by rabbits anaesthetized with urethane differed significantly from that formed by rabbits anaesthetized with pentobarbitone sodium. 3. The I.P. injection of a hypertonic solution of sucrose (3 M) decreased bile flow and produced changes in the ionic composition of bile and of plasma. 4. The infusion of sodium taurodeoxycholate (1-5-20 mumole/min I.V.) gave higher rates of bile flow than did equimolar infusions of sodium taurocholate, and unlike taurocholate, increased the bicarbonate concentration of bile. 5. Acetazolamide (10-100 mg/kg) increased the concentration of bicarbonate both in bile and in plasma, and had little effect on bile flow. 6. The infusion of bromsulphthalein (5 mg/kg I.V.) decreased the excretion of bicarbonate into bile, and was associated with the formation of a hypotonic bile. 7. The implications of these results in relation to the mechanisms of bile secretion are discussed.

Full text

PDF
567

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chenderovitch J., Phocas E., Rautureau M. Effects of hypertonic solutions on bile formation. Am J Physiol. 1963 Nov;205(5):863–867. doi: 10.1152/ajplegacy.1963.205.5.863. [DOI] [PubMed] [Google Scholar]
  2. Erlinger S., Dhumeaux D., Berthelot P., Dumont M. Effect of inhibitors of sodium transport on bile formation in the rabbit. Am J Physiol. 1970 Aug;219(2):416–422. doi: 10.1152/ajplegacy.1970.219.2.416. [DOI] [PubMed] [Google Scholar]
  3. Forker E. L. Two sites of bile formation as determined by mannitol and erythritol clearance in the guinea pig. J Clin Invest. 1967 Jul;46(7):1189–1195. doi: 10.1172/JCI105612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gregg J. A., Poley J. R. Excretion of bile acids in normal rabbits. Am J Physiol. 1966 Nov;211(5):1147–1151. doi: 10.1152/ajplegacy.1966.211.5.1147. [DOI] [PubMed] [Google Scholar]
  5. HASLEWOOD G. A. D., WOOTTON V. Comparative studies of 'bile salts'; preliminary survey. Biochem J. 1950 Nov-Dec;47(5):584–597. doi: 10.1042/bj0470584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Javitt N. B., Emerman S. Effect of sodium taurolithocholate on bile flow and bile acid exeretion. J Clin Invest. 1968 May;47(5):1002–1014. doi: 10.1172/JCI105790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KNIGHTLY J. J., VANAMEE P., LAWRENCE W., Jr The effect of intraduodenal hypertonic glucose on biliary and pancreatic secretion. Surg Forum. 1960;11:371–373. [PubMed] [Google Scholar]
  8. Klaassen C. D. Species differences in the choleretic response to bile salts. J Physiol. 1972 Jul;224(2):259–269. doi: 10.1113/jphysiol.1972.sp009893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Maren T. H. Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol Rev. 1967 Oct;47(4):595–781. doi: 10.1152/physrev.1967.47.4.595. [DOI] [PubMed] [Google Scholar]
  10. O'Máille E. R., Richards T. G., Short A. H. Acute taurine depletion and maximal rates of hepatic conjugation and secretion of cholic acid in the dog. J Physiol. 1965 Sep;180(1):67–79. [PMC free article] [PubMed] [Google Scholar]
  11. O'Máille E. R., Richards T. G., Short A. H. Factors determining the maximal rate of organic anion secretion by the liver and further evidence on the hepatic site of action of the hormone secretin. J Physiol. 1966 Oct;186(2):424–438. doi: 10.1113/jphysiol.1966.sp008044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rutishauser C. B., Stone S. L. Proceedings: Aspects of bile secretion in the rabbit. J Physiol. 1974 Apr;238(1):46P–47P. [PubMed] [Google Scholar]
  13. SPERBER I. Secretion of organic anions in the formation of urine and bile. Pharmacol Rev. 1959 Mar;11(1):109–134. [PubMed] [Google Scholar]
  14. Wheeler H. O., Ramos O. L. DETERMINANTS OF THE FLOW AND COMPOSITION OF BILE IN THE UNANESTHETIZED DOG DURING CONSTANT INFUSIONS OF SODIUM TAUROCHOLATE. J Clin Invest. 1960 Jan;39(1):161–170. doi: 10.1172/JCI104015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wheeler H. O., Ross E. D., Bradley S. E. Canalicular bile production in dogs. Am J Physiol. 1968 Apr;214(4):866–874. doi: 10.1152/ajplegacy.1968.214.4.866. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES