There was a mistake in Figure 3 as published. The image for the Cisplatin + Fer-1 group was used incorrectly. The corrected Figure 3 appears below.
FIGURE 3.
LicoA protects HK-2 cells against cisplatin-induced lipid peroxidation and ferroptosis. (A) GSH levels. (B) MDA levels. (C) Fe2+ levels. (D,E) ROS levels. (F–H) Lipid peroxidation levels. (I,J) Co-stained with phalloidin and DAPI. White arrows indicate the bulges of the cell membrane. The number of cells with blistered membranes was calculated. Scale bar = 50 μm. Results are expressed as means ± SEM, all n = 6 per group unless stated. *p < 0.05, **p < 0.01, ***p < 0.001.
There was a mistake in Figure 6 as published. The image for the Cisplatin group under the si-Nrf2 condition were used incorrectly. The corrected Figure 6 appears below.
FIGURE 6.
LicoA suppresses ferroptosis in HK-2 cells in an Nrf2-dependent manner. (A,B) ROS fluorescence levels. Scale bar = 50 μm, n = 6. (C–E) Lipid peroxidation levels. Scale bar = 20 μm, n = 6. (F–H) The protein expression of GPX4 and xCT in HK-2 cells, n = 3. (I) Mitochondrial morphology, Scale bar = 20 μm. (J–M) Mitochondrial mean perimeter, networks, mean branch length, and individual branches. n = 16–25, scale bar = 20 μm. Results are expressed as means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.
The original article has been updated.
Footnotes
Edited and reviewed by: Xiaoxin Wang, Georgetown University Medical Center, United States
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