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. 1974 Sep;241(2):359–372. doi: 10.1113/jphysiol.1974.sp010660

Active transport of sodium and potassium by the choroid plexus of the rat

Conrad E Johanson, Donal J Reed, Dixon M Woodbury
PMCID: PMC1331036  PMID: 4443922

Abstract

1. Choroid plexus from the lateral ventricle in the adult rat was found to contain approximately 54 m-equiv Na+ and 89 m-equiv K+ per kg wet tissue.

2. The total water (79%), the extracellular space (21%) and the red blood cell volume (8-9%) in choroid plexus were quantified separately by analysing the distribution of [14C]antipyrine, [14C]inulin and 51Cr-tagged erythrocytes, respectively, between this tissue and plasma water.

3. The tissue electrolyte data together with the compartmental (space) data were used to calculate an average concentration of Na+ (39 m-equiv/kg cell H2O) and of K+ (144) in the choroid cell.

4. Under various experimental conditions known to stimulate or inhibit the Na+—K+ transport system in other tissues, there were significant changes (10-40 m-equiv/kg cell H2O) in the concentrations of both these cations in the plexus epithelial cells.

5. Choroid cell K+ was not independent of the concentration of K+ in plasma since substantial fluctuations in cell K+ occurred in rats rendered either hypo- or hyperkalaemic; also, the choroid cell apparently cannot maintain a constant gradient between itself and c.s.f. in the face of kalaemic disturbances.

6. Evidence is offered to support the hypothesis that the choroid plexus of the lateral ventricle has a Na+—K+ pump, the operation of which contributes to the maintenance of K+ homoeostasis in the C.N.S.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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