Abstract
1. Stretching the atrial appendages in anaesthetized dogs caused an increase in heart rate. This response was unrelated to changes in arterial blood pressure and left and right atrial pressures.
2. The increase in heart rate was a reflex response; the afferent path was in the vagi and the efferent solely in the sympathetic nerves.
3. The receptors involved in this reflex have been localized to the atrial appendages but there is no conclusive evidence as to their nature.
Full text
PDF














Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COLERIDGE J. C., HEMINGWAY A., HOLMES R. L., LINDEN R. J. The location of atrial receptors in the dog: a physiological and histological study. J Physiol. 1957 Apr 3;136(1):174–197. doi: 10.1113/jphysiol.1957.sp005750. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLMES R. L. Cholinesterase activity in the atrial wall of the dog and cat heart. J Physiol. 1957 Aug 6;137(3):421–426. doi: 10.1113/jphysiol.1957.sp005823. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLMES R. L. Structures in the atrial endocardium of the dog which stain with methylene blue, and the effects of unilateral vagotomy. J Anat. 1957 Apr;91(2):259–266. [PMC free article] [PubMed] [Google Scholar]
- Johnston B. D. Nerve endings in the human endocardium. Am J Anat. 1968 May;122(3):621–629. doi: 10.1002/aja.1001220312. [DOI] [PubMed] [Google Scholar]
- Kappagoda C. T., Linden R. J., Saunders D. A. The effect of distending the right and left atrial appendages in the dog. J Physiol. 1972 Apr;222(1):35P–36P. [PubMed] [Google Scholar]
- Kappagoda C. T., Linden R. J., Snow H. M. A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium. J Physiol. 1972 Jan;220(1):177–197. doi: 10.1113/jphysiol.1972.sp009700. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kappagoda C. T., Linden R. J., Snow H. M. An approach to the problems of acid-base balance. Clin Sci. 1970 Aug;39(2):169–182. doi: 10.1042/cs0390169. [DOI] [PubMed] [Google Scholar]
- LEDSOME J. R., LINDEN R. J. A REFLEX INCREASE IN HEART RATE FROM DISTENSION OF THE PULMONARY-VEIN-ATRIAL JUNCTIONS. J Physiol. 1964 Apr;170:456–473. doi: 10.1113/jphysiol.1964.sp007343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ledsome J. R., Linden R. J., Norman J., Snow H. M. The measurement of pH, PCO2 and PO2 in blood. J Physiol. 1967 Jul;191(2):59P–60P. [PubMed] [Google Scholar]
- Ledsome J. R., Linden R. J. The role of left atrial receptors in th diuretic response to left atrial distension. J Physiol. 1968 Sep;198(2):487–503. doi: 10.1113/jphysiol.1968.sp008619. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MILLER M. R., KASAHARA M. STUDIES ON THE NERVE ENDINGS IN THE HEART. Am J Anat. 1964 Sep;115:217–233. doi: 10.1002/aja.1001150203. [DOI] [PubMed] [Google Scholar]
- Woollard H. H. The Innervation of the Heart. J Anat. 1926 Jul;60(Pt 4):345–373. [PMC free article] [PubMed] [Google Scholar]
