Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1972 Nov;226(3):751–759. doi: 10.1113/jphysiol.1972.sp010007

Changes in statistical parameters during facilitation at the crayfish neuromuscular junction

A Wernig
PMCID: PMC1331174  PMID: 4404686

Abstract

1. Transmitter release at excitatory neuromuscular junctions of the crayfish was studied at different frequencies of stimulation ranging from 1/sec to 20/sec.

2. Over this frequency range the average number of quanta released per stimulus (m) increased with frequency by a factor of 6-7.

3. Analysis of the fluctuations in quantal release using binomial statistics indicated that the increase in m was associated with increase in the average quantal release probability (p) at stimulation frequencies between 5/sec and 20/sec. Between 1/sec and 5/sec there was an apparent increase in the number of quanta available for release (n).

Full text

PDF
751

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atwood H. L., Bittner G. D. Matching of excitatory and inhibitory inputs to crustacean muscle fibers. J Neurophysiol. 1971 Jan;34(1):157–170. doi: 10.1152/jn.1971.34.1.157. [DOI] [PubMed] [Google Scholar]
  2. Bittner G. D. Differentiation of nerve terminals in the crayfish opener muscle and its functional significance. J Gen Physiol. 1968 Jun;51(6):731–758. doi: 10.1085/jgp.51.6.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bittner G. D., Harrison J. A reconsideration of the Poisson hypothesis for transmitter release at the crayfish neuromuscular junction. J Physiol. 1970 Jan;206(1):1–23. doi: 10.1113/jphysiol.1970.sp008994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bittner G. D., Kennedy D. Quantitative aspects of transmitter release. J Cell Biol. 1970 Dec;47(3):585–592. doi: 10.1083/jcb.47.3.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Braun M., Schmidt R. F., Zimmermann M. Facilitation at the frog neuromuscular junction during and after repetitive stimulation. Pflugers Arch Gesamte Physiol Menschen Tiere. 1966;287(1):41–55. doi: 10.1007/BF00362453. [DOI] [PubMed] [Google Scholar]
  6. DEL CASTILLO J., KATZ B. Quantal components of the end-plate potential. J Physiol. 1954 Jun 28;124(3):560–573. doi: 10.1113/jphysiol.1954.sp005129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DEL CASTILLO J., KATZ B. The effect of magnesium on the activity of motor nerve endings. J Physiol. 1954 Jun 28;124(3):553–559. doi: 10.1113/jphysiol.1954.sp005128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DUDEL J., KUFFLER S. W. Mechanism of facilitation at the crayfish neuromuscular junction. J Physiol. 1961 Mar;155:530–542. doi: 10.1113/jphysiol.1961.sp006645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DUDEL J., KUFFLER S. W. The quantal nature of transmission and spontaneous miniature potentials at the crayfish neuromuscular junction. J Physiol. 1961 Mar;155:514–529. doi: 10.1113/jphysiol.1961.sp006644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DUDEL J. POTENTIAL CHANGES IN THE CRAYFISH MOTOR NERVE TERMINAL DURING REPETITIVE STIMULATION. Pflugers Arch Gesamte Physiol Menschen Tiere. 1965 Jan 11;282:323–337. doi: 10.1007/BF00412507. [DOI] [PubMed] [Google Scholar]
  11. Dodge F. A., Jr, Rahamimoff R. Co-operative action a calcium ions in transmitter release at the neuromuscular junction. J Physiol. 1967 Nov;193(2):419–432. doi: 10.1113/jphysiol.1967.sp008367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HUBBARD J. I. REPETITIVE STIMULATION AT THE MAMMALIAN NEUROMUSCULAR JUNCTION, AND THE MOBILIZATION OF TRANSMITTER. J Physiol. 1963 Dec;169:641–662. doi: 10.1113/jphysiol.1963.sp007286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johnson E. W., Wernig A. The binomial nature of transmitter release at the crayfish neuromuscular junction. J Physiol. 1971 Nov;218(3):757–767. doi: 10.1113/jphysiol.1971.sp009642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Katz B., Miledi R. Further study of the role of calcium in synaptic transmission. J Physiol. 1970 May;207(3):789–801. doi: 10.1113/jphysiol.1970.sp009095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Katz B., Miledi R. The effect of temperature on the synaptic delay at the neuromuscular junction. J Physiol. 1965 Dec;181(3):656–670. doi: 10.1113/jphysiol.1965.sp007790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Katz B., Miledi R. The role of calcium in neuromuscular facilitation. J Physiol. 1968 Mar;195(2):481–492. doi: 10.1113/jphysiol.1968.sp008469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Maeno T., Edwards C. Neuromuscular facilitation with low-frequency stimulation and effects of some drugs. J Neurophysiol. 1969 Sep;32(5):785–792. doi: 10.1152/jn.1969.32.5.785. [DOI] [PubMed] [Google Scholar]
  18. Mallart A., Martin A. R. An analysis of facilitation of transmitter release at the neuromuscular junction of the frog. J Physiol. 1967 Dec;193(3):679–694. doi: 10.1113/jphysiol.1967.sp008388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mallart A., Martin A. R. The relation between quantum content and facilitation at the neuromuscular junction of the frog. J Physiol. 1968 Jun;196(3):593–604. doi: 10.1113/jphysiol.1968.sp008525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rahamimoff R. A dual effect of calcium ions on neuromuscular facilitation. J Physiol. 1968 Mar;195(2):471–480. doi: 10.1113/jphysiol.1968.sp008468. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES