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. 1972 Oct;226(2):431–452. doi: 10.1113/jphysiol.1972.sp009992

Gastric secretion and its facilitation as related to gastric mucosal histamine

Irene Johansson, L Lundell, Elsa Rosengren, S E Svensson
PMCID: PMC1331189  PMID: 4563731

Abstract

1. In conscious rats provided with Pavlov or Heidenhain pouches the acid and pepsin responses to vagal stimulation, or infusions of gastrin, histamine, methacholine, and to various combinations of these stimulants have been established. The concomitant mobilization and increased formation of gastric mucosal histamine have also been examined.

2. Histamine evoked graded acid responses in the Pavlov and Heidenhain pouches. The innervated pouch was more sensitive to histamine than the denervated. Stimulation of pepsin secretion was apparent only in the Heidenhain pouch.

3. The acid response to vagal stimulation evoked by 2-deoxy-D-glucose was facilitated by infusion of histamine, but not that of pepsin, the secretion of which was depressed.

4. Acid secretion in response to graded infusion of methacholine was enhanced by background infusions of histamine in subthreshold, sub-maximal and maximal dosages.

5. The acid response to vagal stimulation was enhanced by a background infusion of gastrin, but not that of pepsin, the secretion of which was depressed.

6. A background infusion of a large dose of histamine depressed the maximal acid response to gastrin in both types of pouches.

7. Administration of histamine restrained the accelerating effect of gastrin on histidine decarboxylase activity, probably by a feed-back coupling.

8. The increase in gastric mucosal histamine, as reflected in its urinary excretion, in response to gastrin infusion was enhanced by vagal stimulation.

9. The amounts of histamine that can be mobilized and newly formed in the gastric mucosa have been evaluated and found to be fully adequate for efficient stimulation of the parietal cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALPHIN R. S., LIN T. M. Preparation of chronic denervated gastric pouches in the rat. Am J Physiol. 1959 Aug;197:257–259. doi: 10.1152/ajplegacy.1959.197.2.257. [DOI] [PubMed] [Google Scholar]
  2. ANDERSSON S., GROSSMAN M. I. EFFECT OF VAGAL DENERVATION OF POUCHES ON GASTRIC SECRETION IN DOGS WITH INTACT OR RESECTED ANTRUMS. Gastroenterology. 1965 Apr;48:449–462. [PubMed] [Google Scholar]
  3. ANDERSSON S., OLBE L. GASTRIC ACID SECRETORY RESPONSES TO GASTRIN AND HISTAMINE IN DOGS BEFORE AND AFTER VAGAL DENERVATION OF THE GASTRIC POUCH. Acta Physiol Scand. 1964 Jan-Feb;60:51–56. doi: 10.1111/j.1748-1716.1964.tb02868.x. [DOI] [PubMed] [Google Scholar]
  4. Colin-Jones D. G., Himsworth R. L. The location of the chemoreceptor controlling gastric acid secretion during hypoglycaemia. J Physiol. 1970 Feb;206(2):397–409. doi: 10.1113/jphysiol.1970.sp009020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cooke A. R. Potentiation of acid secretion in dogs. Am J Physiol. 1969 Apr;216(4):968–973. doi: 10.1152/ajplegacy.1969.216.4.968. [DOI] [PubMed] [Google Scholar]
  6. Feinblatt J., Gelfand T., Smith G. P. Gastric acid response to 2-deoxy-D-glucose in chronic fistula rats. Proc Soc Exp Biol Med. 1966 Oct;123(1):241–242. doi: 10.3181/00379727-123-31455. [DOI] [PubMed] [Google Scholar]
  7. GUSTAFSSON B., KAHLSON G., ROSENGREN E. Biogenesis of histamine studied by its distribution and urinary excretion in germ free reared and not germ free rats fed a histamine free diet. Acta Physiol Scand. 1957 Dec 7;41(2-3):217–228. doi: 10.1111/j.1748-1716.1957.tb01522.x. [DOI] [PubMed] [Google Scholar]
  8. HIGH D. P., SHEPHERD D. M., WOODCOCK B. G. URINARY HISTAMINE EXCRETION IN THE GASTRECTOMISED RAT. Life Sci. 1965 Apr;4:787–795. doi: 10.1016/0024-3205(65)90311-5. [DOI] [PubMed] [Google Scholar]
  9. Holzbauer M., Newport H. M. Quantitative estimation of 17alpha-hydroxypregn-4-ene-3,20-dione (17alphaOH-progesterone) in adrenal venous blood and adrenal glands. J Physiol. 1968 Sep;198(1):91–102. doi: 10.1113/jphysiol.1968.sp008595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hunt J. N. A method for estimating peptic activity in gastric contents. Biochem J. 1948;42(1):104–109. doi: 10.1042/bj0420104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. James R. M. Rat gastric acid secretion studies with histamine and synthetic gastrin-like pentapeptide. J Physiol. 1971 Jan;212(1):181–193. doi: 10.1113/jphysiol.1971.sp009316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Johansson I., Lundell L., Svensson S. E. Inhibition of gastric secretion by atropine in conscious rats. J Physiol. 1971 Sep;217(3):723–735. doi: 10.1113/jphysiol.1971.sp009596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johansson I., Lundell L., Svensson S. E. Inhibition of gastrin-induced gastric secretion by atropine in innervated and denervated pouches in the conscious rat. J Physiol. 1971 May;215(1):38P–39P. [PubMed] [Google Scholar]
  14. KAHLSON G., ROSENGREN E., SVAHN D., THUNBERG R. MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION. J Physiol. 1964 Nov;174:400–416. doi: 10.1113/jphysiol.1964.sp007494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. KAHLSON G., ROSENGREN E., THUNBERG R. OBSERVATIONS ON THE INHIBITION OF HISTAMINE FORMATION. J Physiol. 1963 Dec;169:467–486. doi: 10.1113/jphysiol.1963.sp007273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. KAHLSON G., ROSENGREN E., WESTLING H. Increased formation of histamine in the pregnant rat. J Physiol. 1958 Aug 29;143(1):91–103. doi: 10.1113/jphysiol.1958.sp006046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kahlson G., Rosengren E., Thunberg R. Accelerated mobilization and formation of histamine in the gastric mucosa evoked by vagal excitation. J Physiol. 1967 Jun;190(3):455–463. doi: 10.1113/jphysiol.1967.sp008221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Konturek S. J. Effect of graded doses of pentagastrin, histamine and 2-deoxy-D-glucose on gastric secretion and motility in conscious rats. Scand J Gastroenterol. 1968;3(6):572–576. [PubMed] [Google Scholar]
  19. Müller E. E., Cocchi D., Forni A. A central site for the hyperglycemic action of 2-deoxy-d-glucose in mouse and rat. Life Sci I. 1971 Sep 15;10(18):1057–1067. doi: 10.1016/0024-3205(71)90180-9. [DOI] [PubMed] [Google Scholar]
  20. PASSARO E. P., Jr, GILLESPIE I. E., GROSSMAN M. I. POTENTIATION BETWEEN GASTRIN AND HISTAMINE IN STIMULATION OF GASTRIC SECRETION. Proc Soc Exp Biol Med. 1963 Oct;114:50–52. doi: 10.3181/00379727-114-28582. [DOI] [PubMed] [Google Scholar]
  21. Rosengren E., Svensson S. E. The role of the antrum and the vagus nerve in the formation of gastric mucosal histamine. J Physiol. 1969 Nov;205(2):275–288. doi: 10.1113/jphysiol.1969.sp008964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Svensson S. E. Gastric secretion in unanaesthetized Pavlov pouch rats. J Physiol. 1969 Feb;200(2):116P–118P. [PubMed] [Google Scholar]
  23. Svensson S. E. Secretory behaviour and histamine formation in the rat Heidenhain pouch following antrectomy. J Physiol. 1970 May;207(3):699–708. doi: 10.1113/jphysiol.1970.sp009089. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Svensson S. E. The secretory pattern of three stomach preparations in the rat. J Physiol. 1970 Apr;207(2):329–350. doi: 10.1113/jphysiol.1970.sp009064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Thunberg R. Localization of cells containing and forming histamine in the gastric mucosa of the rat. Exp Cell Res. 1967 Aug;47(1):108–115. doi: 10.1016/0014-4827(67)90214-5. [DOI] [PubMed] [Google Scholar]
  26. WESTLING H. The difference in the metabolism of injected [14C]histamine in male and female rats. Br J Pharmacol Chemother. 1958 Dec;13(4):498–500. doi: 10.1111/j.1476-5381.1958.tb00245.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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