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. 1972 Jul;224(2):317–332. doi: 10.1113/jphysiol.1972.sp009897

An attempt at an analysis of the factors determining the time course of the end-plate current

I. The effects of prostigmine and of the ratio of Mg2+ to Ca2+

M Kordaš, I Gabrovec, M Kordaš, B Popovič
PMCID: PMC1331492  PMID: 4341936

Abstract

1. An attempt was made to analyse the factors which might determine the time course of the falling phase of the end-plate current.

2. The end-plate current was measured by `clamping' the membrane potential during neuromuscular transmission.

3. The falling phase of the end-plate current was found to consist of a non-exponential, and an exponential portion, the duration of both of which varies under different experimental conditions.

4. The results suggest that the rate constants determining the dissociation of the receptor—mediator complex seem greatly to influence the time course of the end-plate current.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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