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. 1971 Sep;217(3):547–556. doi: 10.1113/jphysiol.1971.sp009585

Fever produced by prostaglandin E1

W Feldberg, P N Saxena
PMCID: PMC1331562  PMID: 5098081

Abstract

Prostaglandin E1 (PGE1) produces a rise in rectal temperature when injected into the cerebral ventricles of unanaesthetized cats, rabbits and rats. An effect is obtained with as little as 20, and sometimes even with 10 ng.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coceani F., Wolfe L. S. On the action of prostaglandin E1 and prostaglandins from brain on the isolated rat stomach. Can J Physiol Pharmacol. 1966 Nov;44(6):933–950. doi: 10.1139/y66-116. [DOI] [PubMed] [Google Scholar]
  2. Cooper K. E., Cranston W. I., Honour A. J. Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits. J Physiol. 1965 Dec;181(4):852–864. doi: 10.1113/jphysiol.1965.sp007801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cooper K. E., Cranston W. I., Honour A. J. Observations on the site & mode of action of pyrogens in the rabbit brain. J Physiol. 1967 Jul;191(2):325–337. doi: 10.1113/jphysiol.1967.sp008253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FELDBERG W., MYERS R. D. EFFECTS ON TEMPERATURE OF AMINES INJECTED INTO THE CEREBRAL VENTRICLES. A NEW CONCEPT OF TEMPERATURE REGULATION. J Physiol. 1964 Sep;173:226–231. doi: 10.1113/jphysiol.1964.sp007454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Feldberg W., Lotti V. J. Temperature responses to monoamines and an inhibitor of MAO injected into the cerebral ventricles of rats. Br J Pharmacol Chemother. 1967 Sep;31(1):152–161. doi: 10.1111/j.1476-5381.1967.tb01985.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Feldberg W., Myers R. D. Appearance of 5-hydroxytryptamine and an unidentified pharmacologically active lipid acid in effluent from perfused cerebral ventricles. J Physiol. 1966 Jun;184(4):837–855. doi: 10.1113/jphysiol.1966.sp007951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Feldberg W., Myers R. D., Veale W. L. Perfusion from cerebral ventricle to cisterna magna in the unanaesthetized cat. Effect of calcium on body temperature. J Physiol. 1970 Apr;207(2):403–416. doi: 10.1113/jphysiol.1970.sp009069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Feldberg W., Saxena P. N. Mechanism of action of pyrogen. J Physiol. 1970 Nov;211(1):245–261. doi: 10.1113/jphysiol.1970.sp009277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Filkins J. P., Di Luzio N. R. Endotoxin induced hypothermia and tolerance in the rat. Proc Soc Exp Biol Med. 1968 Dec;129(3):724–726. doi: 10.3181/00379727-129-33409. [DOI] [PubMed] [Google Scholar]
  10. HASSELBLATT A., SPROULL D. H. Hyperglycaemia induced by drugs. J Physiol. 1961 Jun;157:124–136. doi: 10.1113/jphysiol.1961.sp006710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lomax P., Foster R. S., Kirkpatrick W. E. Cholinergic and adrenergic interactions in the thermoregulatory centers of the rat. Brain Res. 1969 Oct;15(2):431–438. doi: 10.1016/0006-8993(69)90165-6. [DOI] [PubMed] [Google Scholar]
  12. Myers R. D., Kawa A., Beleslin D. B. Evoked release of 5-HT and NEFA from the hypothalamus of the conscious monkey during thermoregulation. Experientia. 1969;25(7):705–706. doi: 10.1007/BF01897574. [DOI] [PubMed] [Google Scholar]
  13. Myers R. D., Sharpe L. G. Temperature in the monkey: transmitter factors released from the brain during thermoregulation. Science. 1968 Aug 9;161(3841):572–573. doi: 10.1126/science.161.3841.572. [DOI] [PubMed] [Google Scholar]
  14. Myers R. D., Veale W. L. Body temperature: possible ionic mechanism in the hypothalamus controlling the set point. Science. 1970 Oct 2;170(3953):95–97. doi: 10.1126/science.170.3953.95. [DOI] [PubMed] [Google Scholar]
  15. Myers R. D., Yaksh T. L. Control of body temperature in the unanaesthetized monkey by cholinergic and aminergic systems in the hypothalamus. J Physiol. 1969 Jun;202(2):483–500. doi: 10.1113/jphysiol.1969.sp008822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. PORTER P. J., KASS E. H. ROLE OF THE POSTERIOR HYPOTHALAMUS IN MEDIATING THE LETHAL ACTION OF BACTERIAL ENDOTOXIN IN THE RAT. J Immunol. 1965 Apr;94:641–648. [PubMed] [Google Scholar]
  17. STONER H. B. Studies on the mechanism of shock. The activity of the reticulo-endothelial system after limb ischaemia in the rat. Br J Exp Pathol. 1961 Oct;42:523–538. [PMC free article] [PubMed] [Google Scholar]

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