Abstract
1. Entamoeba coli endotoxin was administered intravenously to cats and dogs.
2. The changes in circulating levels of catecholamines and angiotensin following endotoxin were assayed by a continuous superfusion technique.
3. The response of the dog was characterized by an immediate sustained rise in angiotensin levels and a later variable rise in catecholamine levels.
4. The response of the cat was characterized by an early rise in catecholamine levels and a later rise in angiotensin levels.
5. It is concluded that this species difference may reflect the relative importance of renin-angiotensin and sympatho-adrenal systems of dogs and cats, respectively.
Full text
PDF















Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown J. J., Davies D. L., Lever A. F., Robertson J. I., Verniory A. The effect of acute haemorrhage in the dog and man on plasma-renin concentration. J Physiol. 1966 Feb;182(3):649–663. doi: 10.1113/jphysiol.1966.sp007842. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown J. J., Lever A. F., Robertson J. I., Hodge R. L., Lowe R. D., Vane J. R. Concurrent measurement of renin and angiotensin in the circulation of the dog. Nature. 1967 Aug 19;215(5103):853–855. doi: 10.1038/215853a0. [DOI] [PubMed] [Google Scholar]
- Bunag R. D., Page I. H., McCubbin J. W. Neural stimulation of release of renin. Circ Res. 1966 Oct;19(4):851–858. doi: 10.1161/01.res.19.4.851. [DOI] [PubMed] [Google Scholar]
- EGDAHL R. H. The differential response of the adrenal cortex and medulla to bacterial endotoxin. J Clin Invest. 1959 Jul;38(7):1120–1125. doi: 10.1172/JCI103888. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Erdös E. G., Miwa I. Effect of endotoxin shock on the plasma kallikrein-kinin system of the rabbit. Fed Proc. 1968 Jan-Feb;27(1):92–95. [PubMed] [Google Scholar]
- GILBERT R. P. Mechanisms of the hemodynamic effects of endotoxin. Physiol Rev. 1960 Apr;40:245–279. doi: 10.1152/physrev.1960.40.2.245. [DOI] [PubMed] [Google Scholar]
- Greenway C. V., Lautt W. W., Stark R. D. Separation of acute and delayed hemodynamic responses to endotoxin in the cat. Am J Physiol. 1969 Aug;217(2):518–521. doi: 10.1152/ajplegacy.1969.217.2.518. [DOI] [PubMed] [Google Scholar]
- HINSHAW L. B., BRADLEY G. M., CARLSON C. H. Effect of endotoxin on renal function in the dog. Am J Physiol. 1959 May;196(5):1127–1131. doi: 10.1152/ajplegacy.1959.196.5.1127. [DOI] [PubMed] [Google Scholar]
- HINSHAW L. B., JORDAN M. M., VICK J. A. Mechanism of histamine release in endotoxin shock. Am J Physiol. 1961 May;200:987–989. doi: 10.1152/ajplegacy.1961.200.5.987. [DOI] [PubMed] [Google Scholar]
- HINSHAW L. B., SPINK W. W., VICK J. A., MALLET E., FINSTAD J. Effect of endotoxin on kidney function and renal hemodynamics in the dog. Am J Physiol. 1961 Jul;201:144–148. doi: 10.1152/ajplegacy.1961.201.1.144. [DOI] [PubMed] [Google Scholar]
- Hodge R. L., Lowe R. D., Vane J. R. Increased angiotensin formation in response to carotid occlusion in the dog. Nature. 1966 Jul 30;211(5048):491–493. doi: 10.1038/211491a0. [DOI] [PubMed] [Google Scholar]
- Hodge R. L., Lowe R. D., Vane J. R. The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs. J Physiol. 1966 Aug;185(3):613–626. doi: 10.1113/jphysiol.1966.sp008005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ICK J. A. BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDOTOXIN SHOCK. Am J Physiol. 1965 Jul;209:75–78. doi: 10.1152/ajplegacy.1965.209.1.75. [DOI] [PubMed] [Google Scholar]
- KUIDA H., GILBERT R. P., HINSHAW L. B., BRUNSON J. G., VISSCHER M. B. Species differences in effect of gram-negative endotoxin on circulation. Am J Physiol. 1961 Jun;200:1197–1202. doi: 10.1152/ajplegacy.1961.200.6.1197. [DOI] [PubMed] [Google Scholar]
- KUIDA H., HINSHAW L. B., GILBERT R. P., VISSCHER M. B. Effect of gram-negative endotoxin on pulmonary circulation. Am J Physiol. 1958 Feb;192(2):335–344. doi: 10.1152/ajplegacy.1958.192.2.335. [DOI] [PubMed] [Google Scholar]
- MACLEAN L. D., SPINK W. W., VISSCHER M. B., WEIL M. H. Studies on the circulatory changes in the dog produced by endotoxin from gram-negative microorganisms. J Clin Invest. 1956 Nov;35(11):1191–1198. doi: 10.1172/JCI103373. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MACLEAN L. D., WEIL M. H. Hypotension (shock) in dogs produced by Escherichia coli endotoxin. Circ Res. 1956 Sep;4(5):546–556. doi: 10.1161/01.res.4.5.546. [DOI] [PubMed] [Google Scholar]
- NYKIEL F., GLAVIANO V. V. Adrenal catecholamines in E. coli endotoxin shock. J Appl Physiol. 1961 Mar;16:348–350. doi: 10.1152/jappl.1961.16.2.348. [DOI] [PubMed] [Google Scholar]
- Nies A. S., Forsyth R. P., Williams H. E., Melmon K. L. Contribution of kinins to endotoxin shock in unanesthetized Rhesus monkeys. Circ Res. 1968 Feb;22(2):155–164. doi: 10.1161/01.res.22.2.155. [DOI] [PubMed] [Google Scholar]
- PATON W. D. A pendulum auxotonic lever. J Physiol. 1957 Jul 11;137(2):35P–356. [PubMed] [Google Scholar]
- ROSENBERG J. C., LILLEHEI R. C., LONGERBEAM J., ZIMMERMANN B. Studies on hemorrhagic and endotoxin shock in relation to vasomotor changes and endogenous circulating epinephrine, norepinephrine and serotonin. Ann Surg. 1961 Oct;154:611–628. doi: 10.1097/00000658-196110000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Regoli D., Vane J. R. The continuous estimation of angiotensin formed in the circulation of the dog. J Physiol. 1966 Apr;183(3):513–531. doi: 10.1113/jphysiol.1966.sp007881. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spink W. W., Reddin J., Zak S. J., Peterson M., Starzecki B., Seljeskog E. Correlation of plasma catecholamine levels with hemodynamic changes in canine endotoxin shock. J Clin Invest. 1966 Jan;45(1):78–85. doi: 10.1172/JCI105325. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Staszewska-Barczak J., Ceremuzynski L. The continuous estimation of catecholamine release in the early stages of myocardial infarction in the dog. Clin Sci. 1968 Jun;34(3):531–539. [PubMed] [Google Scholar]
- Stein M., Thomas D. P. Role of platelets in the acute pulmonary responses to endotoxin. J Appl Physiol. 1967 Jul;23(1):47–52. doi: 10.1152/jappl.1967.23.1.47. [DOI] [PubMed] [Google Scholar]
- Vander A. J. Control of renin release. Physiol Rev. 1967 Jul;47(3):359–382. doi: 10.1152/physrev.1967.47.3.359. [DOI] [PubMed] [Google Scholar]
- Vane J. R. The release and fate of vaso-active hormones in the circulation. Br J Pharmacol. 1969 Feb;35(2):209–242. doi: 10.1111/j.1476-5381.1969.tb07982.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- White F. N., Gold E. M., Vaughn D. L. Renin-aldosterone system in endotoxin shock in the dog. Am J Physiol. 1967 May;212(5):1195–1198. doi: 10.1152/ajplegacy.1967.212.5.1195. [DOI] [PubMed] [Google Scholar]
