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. 1971 Mar;213(3):525–531. doi: 10.1113/jphysiol.1971.sp009397

Platelet aggregation and strenuous exercise

L Poller, Celia M Priest, Jean M Thomson
PMCID: PMC1331738  PMID: 5551400

Abstract

1. Platelet aggregation in the Chandler's tube has been found to be increased in a group of normal male and female volunteers who undertook strenuous physical exercise. This coincided with acceleration of the `intrinsic' blood clotting system and a rise in fibrinogen. The rise in fibrinogen occurred despite increased fibrinolysis.

2. The study confirms the sensitivity of the platelet aggregation system to changes in the `intrinsic' clotting mechanism. Acceleration of this system in this study resulted from a physiological cause and produced accelerated aggregation in the coagulation-affected phase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASTRUP T., MULLERTZ S. The fibrin plate method for estimating fibrinolytic activity. Arch Biochem Biophys. 1952 Oct;40(2):346–351. doi: 10.1016/0003-9861(52)90121-5. [DOI] [PubMed] [Google Scholar]
  2. BRAKMAN P., ASTRUP T. EFFECTS OF FEMALE HORMONES, USED AS ORAL CONTRACEPTIVES, ON THE FIBRINOLYTIC SYSTEM IN BLOOD. Lancet. 1964 Jul 4;2(7349):10–12. doi: 10.1016/s0140-6736(64)90005-4. [DOI] [PubMed] [Google Scholar]
  3. CUNNINGHAM G. M., MCNICOL G. P., DOUGLAS A. S. EFFECT OF ANTICOAGULANT DRUGS ON PLATELET AGGREGATION IN THE CHANDLER'S TUBE. Lancet. 1965 Apr 3;1(7388):729–730. doi: 10.1016/s0140-6736(65)92089-1. [DOI] [PubMed] [Google Scholar]
  4. FEARNLEY G. R., BALMFORTH G., FEARNLEY E. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis. Clin Sci. 1957 Nov;16(4):645–650. [PubMed] [Google Scholar]
  5. HELLEM A., OWREN P. A. THE MECHANISM OF THE HEMOSTATIC FUNCTION OF BLOOD PLATELETS. Acta Haematol. 1964 Apr;31:230–238. doi: 10.1159/000209632. [DOI] [PubMed] [Google Scholar]
  6. HJORT P., RAPAPORT S. I., OWREN P. A. A simple, specific one-stage prothrombin assay using Russell's viper venom in cephalin suspension. J Lab Clin Med. 1955 Jul;46(1):89–97. [PubMed] [Google Scholar]
  7. INGRAM G. I. Increase in antihaemophilic globulin activity following infusion of adrenaline. J Physiol. 1961 Apr;156:217–224. doi: 10.1113/jphysiol.1961.sp006670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. POLLER L. STANDARDIZATION OF ANTICOAGULANT TREATMENT: THE MANCHESTER REGIONAL THROMBOPLASTIN SCHEME. Br Med J. 1964 Aug 29;2(5408):565–566. doi: 10.1136/bmj.2.5408.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. POLLER L., THOMSON J. EVIDENCE FOR "REBOUND" HYPERCOAGULABILITY AFTER STOPPING ANTICOAGULANTS. Lancet. 1964 Jul 11;2(7350):62–64. doi: 10.1016/s0140-6736(64)90067-4. [DOI] [PubMed] [Google Scholar]
  10. Poller L., Thomson J. M., Priest C. M. Coumarin therapy and platelet aggregation. Br Med J. 1969 Feb 22;1(5642):474–476. doi: 10.1136/bmj.1.5642.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. RIZZA C. R. Effect of exercise on the level of antihaemophilic globulin in human blood. J Physiol. 1961 Apr;156:128–135. doi: 10.1113/jphysiol.1961.sp006663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Solum N. O., Stormorken H. Influence of fibrinogen on the aggregation of washed human blood platelets induced by adenosine diphosphate, thrombin, collagen, and adrenaline. Scand J Clin Lab Invest. 1965;17(Suppl):170+–170+. [PubMed] [Google Scholar]
  13. THOMSON J. M., POLLER L. ORAL CONTRACEPTIVE HORMONES AND BLOOD COAGULABILITY. Br Med J. 1965 Jul 31;2(5456):270–273. doi: 10.1136/bmj.2.5456.270. [DOI] [PMC free article] [PubMed] [Google Scholar]

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