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. 1971 Oct;218(2):337–351. doi: 10.1113/jphysiol.1971.sp009621

The permeation of several materials into the fluids of the rabbit's brain

Hugh Davson, Keasley Welch
PMCID: PMC1331799  PMID: 5124569

Abstract

1. 24Na, 36Cl and 35S thiourea were infused I.V. in rabbits according to schedules designed to yield approximately level activity in plasma for periods up to 5 hr. Cerebrospinal fluid was sampled before ending the experiment by decapitation and the radioactivities in cerebrospinal fluid and in homogenized brain were compared in each case to a time weighted mean value for plasma.

2. The results are considered in terms of a simplified model which specifically acknowledges the continuity of the extracellular and cerebrospinal fluids and thus the coupling between processes which occur at the interfaces bordering those fluids.

3. From the rate constants for exchange across the blood—brain interface that were necessary for simulation of the observed behaviours, permeability coefficients for that interface were estimated for the materials studied and, from experiments of others, for 42K.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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