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. 1971 Oct;218(2):369–383. doi: 10.1113/jphysiol.1971.sp009623

Inhibition by prostaglandin E1 of gastric secretion in the dog

James E Nezamis, André Robert, David F Stowe
PMCID: PMC1331801  PMID: 4399409

Abstract

1. The effect of prostaglandin E1 (PGE1) on gastric secretion was studied in dogs equipped with gastric fundic pouches, either innervated (Pavlov) or denervated (Heidenhain).

2. PGE1 inhibited gastric secretion (volume, acid concentration, acid output, pepsin output) when given either by constant intravenous infusion or by single intravenous injection. The degree of inhibition was dose dependent.

3. The antisecretory effect of PGE1 was demonstrated against gastric stimulants which operate through different mechanisms. Thus, PGE1 counteracted the secretogogue effect of:

(a) histamine dihydrochloride; the ED50 was 0·5-1·0 μg/kg. min for a submaximal dose, and 1·0-1·5 μg/kg. min for a maximal dose;

(b) pentagastrin; the ED50 was around 0·25 μg/kg. min;

(c) food; the ED50 was 0·5 to 0·75 μg/kg. min;

(d) 2-deoxyglucose; the ED50 was less than 0·1 μg/kg. min.

4. Although in some experiments, nausea and vomiting were observed during administration of PGE1, the antisecretory property of the substance is not related to a vomiting reflex, since

(a) an antiemetic, such as atropine, prevented vomiting without interfering with the effect of PGE1, and

(b) profuse vomiting elicited by apomorphine did not reduce gastric secretion stimulated by either histamine or pentagastrin.

5. The mechanism by which PGE1 inhibits gastric secretion is unknown. Studies by others have shown that the compound reduces gastric mucosal blood flow, inhibits acid formation from gastric mucosa when applied in vitro and may change the rate of formation of gastric cyclic AMP. It is likely that PGE1 interferes with biochemical processes, within parietal and chief cells, which lead to elaboration of gastric juice.

6. Unlike most gastric inhibitors, PGE1 appears to act as a protective shield against most, if not all, gastric stimulants. Since prostaglandins of the E series are naturally occurring substances and are normally present in the stomach, they may play a role in the regulation of gastric secretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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