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. 1971 Apr;214(1):115–126. doi: 10.1113/jphysiol.1971.sp009422

The contribution of the adrenal gland to the total amount of progesterone produced in the female rat

A B Fajer, Margarethe Holzbauer, Helen M Newport
PMCID: PMC1331825  PMID: 5575348

Abstract

1. The amount of progesterone contained in both adrenal glands of a rat was similar to or larger than the amount of progesterone in the ovaries of the same rat. This was found in unstressed rats, in stressed rats and also in pregnant rats.

2. After ether anaesthesia and exsanguination the adrenal progesterone content was increased by 75%; the ovarian progesterone content remained unchanged.

3. In contrast, prolonged operative stress resulted in a rise in the ovarian content of progesterone and 20-dihydroprogesterone whereas the adrenal progesterone content of these rats was lower than that of unstressed rats.

4. The rate at which progesterone was secreted by the adrenal glands of stressed rats was similar to the ovarian progesterone secretion rate. Rats which were kept under mild stress conditions before the experiment showed higher adrenal progesterone secretion rates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. EBERLEIN W. R., BONGIOVANNI A. M. New solvent systems for the resolution of corticosteroids by paper chromatography. Arch Biochem Biophys. 1955 Nov;59(1):90–96. doi: 10.1016/0003-9861(55)90465-3. [DOI] [PubMed] [Google Scholar]
  2. Fajer A. B., Barraclough C. A. Ovarian secretion of progesterone and 20-alpha-hydroxypregn-4-en-3-one during pseudopregnancy and pregnancy in rats. Endocrinology. 1967 Sep;81(3):617–622. doi: 10.1210/endo-81-3-617. [DOI] [PubMed] [Google Scholar]
  3. Feder H. H., Resko J. A., Goy R. W. Progesterone levels in the arterial plasma of pre-ovulatory and ovariectomized rats. J Endocrinol. 1968 Aug;41(4):563–569. doi: 10.1677/joe.0.0410563. [DOI] [PubMed] [Google Scholar]
  4. Feder H. H., Ruf K. B. Stimulation of progesterone release and estrous behavior by ACTH in ovariectomized rodents. Endocrinology. 1969 Jan;84(1):171–174. doi: 10.1210/endo-84-1-171. [DOI] [PubMed] [Google Scholar]
  5. GIULIANI G., MARTINI L., PECILE A., FOCHI M. Studies on luteinizing hormone release and inhibition. Acta Endocrinol (Copenh) 1961 Sep;38:1–12. doi: 10.1530/acta.0.0380001. [DOI] [PubMed] [Google Scholar]
  6. HOLZBAUER M. THE PART PLAYED BY ACTH IN DETERMINING THE RATE OF ALDOSTERONE SECRETION DURING OPERATIVE STRESS. J Physiol. 1964 Jul;172:138–149. doi: 10.1113/jphysiol.1964.sp007408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hashimoto I., Henricks D. M., Anderson L. L., Melampy R. M. Progesterone and pregn-4-en-20 alpha-ol-3-one in ovarian venous blood during various reproductive states in the rat. Endocrinology. 1968 Feb;82(2):333–341. doi: 10.1210/endo-82-2-333. [DOI] [PubMed] [Google Scholar]
  8. Heap R. B., Holzbauer M., Newport H. M. Adrenal secretion rates of C-19 and C-21 steroids before and after hypophysectomy in the pig and the dog. J Endocrinol. 1966 Oct;36(2):159–176. doi: 10.1677/joe.0.0360159. [DOI] [PubMed] [Google Scholar]
  9. Holzbauer M., Newport H. M. Adrenal secretion rates and adrenal tissue concentrations of pregnenolone, progesterone, 11 beta OH-androstenedione and some other steroids in young pigs and dogs. J Physiol. 1969 Feb;200(3):821–848. doi: 10.1113/jphysiol.1969.sp008724. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Holzbauer M., Newport H. M., Birmingham M. K., Traikov H. Secretion of pregn-4-ene-3,20-dione (progesterone) in vivo by the adrenal gland of the rat. Nature. 1969 Feb 8;221(5180):572–573. doi: 10.1038/221572b0. [DOI] [PubMed] [Google Scholar]
  11. Holzbauer M., Newport H. M. The effect of stress on the concentration of 3beta-hydroxypregn-5-en-20-one (pregnenolone) and pregn-4-ene-3,20-dione (progesterone) in the adrenal gland of the rat. J Physiol. 1967 Nov;193(1):131–140. doi: 10.1113/jphysiol.1967.sp008347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lindner H. R., Zmigrod A. Microdetermination of progestins in rat ovaries: progesterone and 20 alpha-hydroxy-pregn-4-en-3-one content during proestrus, oestrus and pseudopregnancy. Acta Endocrinol (Copenh) 1967 Sep;56(1):16–26. doi: 10.1530/acta.0.0560016. [DOI] [PubMed] [Google Scholar]
  13. SHORT R. V. The secretion of sex hormones by the adrenal gland. Biochem Soc Symp. 1960;18:59–84. [PubMed] [Google Scholar]
  14. Sulimovici S. I., Boyd G. S. The cholesterol side-chain cleavage enzymes in steroid hormone-producing tissues. Vitam Horm. 1969;27:199–234. doi: 10.1016/s0083-6729(08)61127-9. [DOI] [PubMed] [Google Scholar]
  15. VOGT M. Inhibition by hexoestrol of adrenocortical secretion in the rat. J Physiol. 1955 Dec 29;130(3):601–614. doi: 10.1113/jphysiol.1955.sp005430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Yoshinaga K., Grieves S. A., Short R. V. Steroidogenic effects of luteinizing hormone and prolactin on the rat ovary in vivo. J Endocrinol. 1967 Aug;38(4):423–430. doi: 10.1677/joe.0.0380423. [DOI] [PubMed] [Google Scholar]

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