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. 1971 May;215(1):119–137. doi: 10.1113/jphysiol.1971.sp009461

Contractions of the caudal region of the oesophagus of the cat

D A Titchen, J S Wheeler
PMCID: PMC1331870  PMID: 5579643

Abstract

1. The motility of the most caudal part of the oesophagus has been investigated in cats which were decerebrated, had the whole of the central nervous system pithed or were anaesthetized with chloralose.

2. Contractions of the most caudal region of the oesophagus were evoked by its stretch and the presence in it of HCl. These reactions were obtained in all types of preparations used.

3. In decerebrate preparations oesophageal contractions occurred in response to the introduction of acid into the stomach. These were not obtained after the vagus ṅerves had been cut.

4. Slight degrees of gastric distension stimulated oesophageal contractions, greater distension was inhibitory.

5. Both reductions in oesophageal activity and contractions of the oesophagus were obtained with different parameters of stimulation of efferent vagal fibres.

6. Excitatory and inhibitory effects on the oesophagus were obtained from stimulation of the central end of the vagus nerves cut in the abdomen or in the neck.

7. In totally pithed preparations of cats stretch of one region of the oesophagus was found to modify the activity of a distant region of the oesophagus cranial or caudal to the site of distension.

8. The reactions of the caudal oesophagus were abolished by atropine.

9. The importance of vago-vagal reflexes in the modification of basically direct oesophageal responses has been discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDREW B. L. Activity in afferent nerve fibres from the cervical oesophagus. J Physiol. 1957 Feb 15;135(2):54–5P. [PubMed] [Google Scholar]
  2. Bremner C. G., Shorter R. G., Ellis F. H., Jr Anatomy of feline esophagus with special reference to its muscular wall and phrenoesophageal membrane. J Surg Res. 1970 Jul;10(7):327–331. doi: 10.1016/0022-4804(70)90051-x. [DOI] [PubMed] [Google Scholar]
  3. CLARK C. G., VANE J. R. The cardiac sphincter in the cat. Gut. 1961 Sep;2:252–262. doi: 10.1136/gut.2.3.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COMLINE R. S., KAY R. N. Reflex secretion by the parotid gland of the sheep. J Physiol. 1955 Sep 28;129(3):55–6P. doi: 10.1113/jphysiol.1955.sp005387. [DOI] [PubMed] [Google Scholar]
  5. COMLINE R. S., TITCHEN D. A. Reflex contraction of the oesophageal groove in young ruminants. J Physiol. 1951 Oct 29;115(2):210–226. doi: 10.1113/jphysiol.1951.sp004666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Christensen J., Daniel E. E. Effects of some autonomic drugs on circular esophageal smooth muscle. J Pharmacol Exp Ther. 1968 Feb;159(2):243–249. [PubMed] [Google Scholar]
  7. Giles G. R., Humphries C., Mason M. C., Clark C. G. Effect of pH changes on the cardiac sphincter. Gut. 1969 Oct;10(10):852–856. doi: 10.1136/gut.10.10.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Giles G. R., Mason M. C., Humphries C., Clark C. G. Action of gastrin on the lower oesophageal sphincter in man. Gut. 1969 Sep;10(9):730–734. doi: 10.1136/gut.10.9.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Harper A. A., McSwiney B. A., Suffolk S. F. Afferent fibres from the abdomen in the vagus nerves. J Physiol. 1935 Oct 26;85(2):267–276. doi: 10.1113/jphysiol.1935.sp003317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. IGGO A. Gastric mucosal chemoreceptors with vagal afferent fibres in the cat. Q J Exp Physiol Cogn Med Sci. 1957 Oct;42(4):398–409. doi: 10.1113/expphysiol.1957.sp001284. [DOI] [PubMed] [Google Scholar]
  11. IGGO A. Gastro-intestinal tension receptors with unmyelinated afferent fibres in the vagus of the cat. Q J Exp Physiol Cogn Med Sci. 1957 Jan;42(1):130–143. doi: 10.1113/expphysiol.1957.sp001228. [DOI] [PubMed] [Google Scholar]
  12. Iggo A., Leek B. F. An electrophysiological study of some reticulo-ruminal and abomasal reflexes in sheep. J Physiol. 1967 Nov;193(1):95–119. doi: 10.1113/jphysiol.1967.sp008345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Iorio L. C., McIsaac R. J. A simplified method for preparing a pithed cat. J Pharm Pharmacol. 1965 Oct;17(10):667–668. doi: 10.1111/j.2042-7158.1965.tb07582.x. [DOI] [PubMed] [Google Scholar]
  14. SCHENK E. A., FREDERICKSON E. L. Pharmacologic evidence for a cardiac sphincter mechanism in the cat. Gastroenterology. 1961 Jan;40:75–80. [PubMed] [Google Scholar]
  15. SELLERS A. F., TITCHEN D. A. Responses to localized distension of the oesophagus in decerebrate sheep. Nature. 1959 Aug 22;184(Suppl 9):645–645. doi: 10.1038/184645a0. [DOI] [PubMed] [Google Scholar]
  16. TITCHEN D. A. Reflex contractions of the reticulum. J Physiol. 1953;122(Suppl):32P–32P. [PubMed] [Google Scholar]
  17. TITCHEN D. A. Reflex stimulation and inhibition of reticulum contractions in the ruminant stomach. J Physiol. 1958 Apr 3;141(1):1–21. doi: 10.1113/jphysiol.1958.sp005950. [DOI] [PMC free article] [PubMed] [Google Scholar]

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