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. 1971 Jul;216(2):391–401. doi: 10.1113/jphysiol.1971.sp009531

Competitive interaction of β-guanidino propionic acid and γ-aminobutyric acid on the muscle fibre of the crayfish

Anne Feltz
PMCID: PMC1331945  PMID: 5559627

Abstract

1. The interaction of β-guanidino propionic acid and γ-aminobutyric acid has been investigated on the crayfish muscle by measurement of the membrane conductance.

2. The increase in membrane conductance produced by GABA is depressed by β-guanidino propionic acid. This antagonist acts in a competitive way as shown by the shift of log dose—response curves and by the results of tests for competitive interaction (method of Schild (1947); Lineweaver and Burk's plot).

3. Perfusion of GABA was shown to induce a receptor desensitization. As a consequence, the slope of the dose—response curve plotted in Hill's co-ordinates increases when care is taken to minimize this phenomenon. The significance of this slope for establishing the real number of GABA molecules binding with the GABA receptor is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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