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. 1971 Jul;216(1):111–127. doi: 10.1113/jphysiol.1971.sp009512

Coronary blood flow, oxygen delivery rate and cardiac performance

Marvin B Bacaner, Franco Lioy, Maurice B Visscher
PMCID: PMC1331963  PMID: 5558342

Abstract

1. Studies have been made on the isolated blood-perfused heart of dogs in which isometric tension development at various settings of resting tension (RT) was measured at various levels of O2 delivery rates controlled by altering (a) coronary blood flow (CBF), (b) O2 capacity or (c) O2 saturation of the perfusate. Measurements were also made of O2 consumption and vascular perfusion resistance.

2. The capacity of the left ventricle to develop tension at any given setting of resting tension was found to be directly correlated with changes in O2 delivery rate using any of the above three methods of altering the latter.

3. The slopes of the curves relating resting tension to developed tension are positively correlated with total O2 delivery to the heart.

4. The O2-dependent metabolic effect upon tension production was found to be slow in development, in contrast to the Frank—Starling effect, which reached full development in the first heart beat after a change in resting length and tension.

5. The O2 consumption of the isometrically contracting heart is strongly correlated with the O2 delivery rate at all particular values of resting tension and related developed tension.

6. The metabolic state of the myocardium as determined by the rate of O2 delivery within physiological ranges is (a) a direct major determinant of the tension-producing capacity of the heart muscle and (b) determines the magnitude of adaptation via the Frank—Starling mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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