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. 1971 Jul;216(1):129–142. doi: 10.1113/jphysiol.1971.sp009513

Formation of saliva and potassium transport in the perfused cat submandibular gland

O H Petersen
PMCID: PMC1331964  PMID: 5558344

Abstract

1. In the cat submandibular gland perfused with modified Locke solutions, salivary secretion during acetylcholine (ACh) infusion and K uptake from the perfusion fluid after the ACh-induced K loss were measured.

2. Strophanthin G (10-5 M) abolished K uptake, whereas salivary secretion was unaffected.

3. Ethacrynic acid (10-4-2 × 10-4 M) hardly affected K uptake whereas salivary secretion was severely inhibited.

4. During perfusion with Ca-free solution K uptake was unaffected, whereas salivary secretion was severely reduced.

5. The presence or absence of CO2/HCO3 in the perfusion fluid was of no importance for the secretory process and the K uptake. Acetazolamide (2 × 10-4-10-3 M) did not inhibit these transport processes.

6. It is suggested that two kinds of Na transport occur in the acinar cells of the salivary glands: a Na extrusion coupled with K uptake, responsible for the maintenance of the concentration gradients across the cell membrane; and a Na transport coupled with Cl transport into the acinar lumen, responsible for the formation of the primary secretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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