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. 2026 Apr 27;16:20111. doi: 10.1038/s41598-026-47544-0

Efficient monitoring of exponential processes using memory control charts for healthcare applications

Syed Masroor Anwar 1,3,✉, Naif Almakayeel 2, Chang-Yun Lin 3,✉
PMCID: PMC13323751  PMID: 42045269

Abstract

Currently, assessing the efficiency of memory control charts both in zero-state (ZS) and steady-state (SS) contexts is a burning issue in the statistical process control (SPC). In certain cases, a memory control chart may demonstrate exceptional performance in the ZS while underperforming in the SS, and researchers assert the superiority of their proposed chart solely based on its ZS performance. Recent research indicates that a control chart receives priority over alternative control charts if it has both superior ZS and SS performances. Keeping in mind, this paper presents the design of two novel cumulative sums (CUSUM) and crosier CUSUM (CCUSUM) control charts termed Inline graphic and Inline graphicincorporating variable transformation based on the assumption of exponential distribution aimed at improving process monitoring in both ZS and SS conditions. The results of the study are derived using the Monte Carlo simulation approach. A number of different metrics are utilized using a variety of indicators. These metrics include the average and standard deviation of run length (RL) denoted by ARL and SDRL. Similarly, the performance comparison index (PCI), relative ARL (RARL), and extra quadratic loss (EQL) are also used as performance indicators. The suggested Inline graphic and Inline graphic charts are contrasted with the rival charts using these performance metrics. According to the results, the suggested control charts are more effective than other control charts when it comes to detecting shifts quickly in ZS and SS. Breast cancer (BS) and urinary tract infection (UTI) are the burning issues in the healthcare monitoring and their early monitoring is very beneficial for treatment. As a last step towards putting the suggested Inline graphic andInline graphic control chart into practice, two examples originating from breast cancer and urinary tract infection are also included.

Supplementary Information

The online version contains supplementary material available at 10.1038/s41598-026-47544-0.

Keywords: Breast cancer, Crosier CUSUM, Exponential process, Steady state, Urinary tract infection

Subject terms: Cancer, Engineering, Mathematics and computing

Introduction

Variations are typically inherent in all manufacturing processes and may be categorized as either unnatural or natural. The natural variations are innocuous and are an integral part of every stable process, whereas the identification and removal of unnatural variations in the process are essential for the process stability and the fine quality of the ultimate products. The Control charts are designed to identify these unnatural variations. Control charts assist practitioners in taking timely remedial action and improving the overall quality of final goods by visually depicting process data and exposing abnormal variations. Memoryless and memory are the two broad categories of control charts. The Shewhart type charts, first developed by Shewhart1, fall under the memoryless category and are excellent at identifying substantial changes in process parameters. However, memory-featured charts, such as those from EWMA and CUSUM, make better use of both past and current information, making them ideal for detecting small mild process changes.

Most of the earlier studies on CUSUM control charts have focused on the normal distribution. To effectively track normal variation, Acosta-Mejia et al.2 suggested three distinct CUSUM control charts. Likewise, to deal with the ambiguous size of the location shift, Ryu et al.3 also presented an effective CUSUM control chart. According to them, their improved CUSUM control chart is severely affected by a difference between the actual and predicted shift sizes. In a similar vein, Tran et al.4 presented the CUSUM control chart for means of two populations. Additionally, Ghobadi et al.5 presented the fuzzy CUSUM chart to the scientific community under multivariate scenario. At the same time, Lucas and Crosier6, as well as Goel and Wu7, proposed the use of CUSUM charts head start and process location. Assuming normality, Sanusi et al.8 presented the CUSUM chart to effectively monitor variability of the process. To effectively monitor both the average and the variations of a process simultaneously, Ou et al.9 presented the adaptive CUSUM control chart. Recently, Sanusi et al.10 and Sanusi et al.11 provided efficient CUSUM charts using various estimators and auxiliary-based Shewhart-CUSUM control chart. Recently, Aliet al.12 suggested CUSUM chart for the process mean with the application of chemical engineering. Similarly, Riaz et al.13 provided a CUSUM based study with the ZS and SS performance criterion. Likewise, Abbas et al. 14 introduced distribution free adaptive CUSUM sign chart for mean. Also, Nazir et al.15 suggested CUSUM based study with the integration of normal and non-normal cased under RSS case. For more related recent studies see16–18.

In practical contexts, it is frequently seen that the data produced by a process does not conform to a normal distribution. Many researchers explored different aspects of non-normal processes. For instance, Duclos and Pillet19 presented a chart that was designed to represent abnormal processes. An L estimator, which can replace the dispersion and location, which are commonly employed in Shewhart charts, is used to create this X/S-like chart. Aslam et al.20 suggested a refined EWMA for the Com-Poisson distribution, showcasing enhanced efficiency in comparison to the classical EWMA chart. In a subsequent analysis, Huberts et al.21 examined the implications of the central limit theorem on the application of Shewhart control charts to big datasets that do not conform to a normal distribution, considering an array of distributions and varying sample sizes. In a similar way, Aslam22 advocated for the utilization of mixed EWMA-CUSUM chart, predicated on the concept of the Weibull process. In a similar vein, Aslam et al.23 provided a control chart for the time between events (TBE) that was developed expressly for the Gamma process. Likewise, Khan et al.24 suggested an efficient dispersion chart for enhanced tracking the process. Recently, Arslan et al.25 provided mixed EWMA-Dual Crosier CUSUM for process location. Now, Waqas et al.26 initiated enhanced EWMA for inverse Maxwell distribution with mechanical industrial applications. Similarly, an AEWMA control chart with healthcare application for inverse Maxwell process is suggested by Waqas et al.27. Also, an enhanced chart for tracking the Rayleigh distribution’s scale parameter was presented by Khan et al.28.

In the realm of exponential processes, where the quality feature in question adheres to an exponential distribution, researchers have suggested several improvements to memory-type control charts. Similarly, Aslam29 used neutrosophic approach to create the sample plan for the exponentially data. For optimal monitoring of the exponentially distributed data, Adeoti and Malela-Majika30 presented a double EWMA (DEWMA) chart. Furthermore, a novel memory chart for the exponential distribution (ED) was developed by Khan et al.31. It is worth noting that Aslam et al.32 introduced an EWMA chart designed to monitor ED; this chart employs probability limits to determine the average run-length (RL) (ARL) for both in-control (IC) and out-of-control (OOC) situations. Nevertheless, the studies conducted by Margavio et al.33, Adams et al.34, Abbasi et al.35, and Rasheed et al.36 have illuminated the limitations and drawbacks of this approach, and Rasheed et al.36 delineated the appropriate methodology for the EWMA chart (denoted as Inline graphic) based on the premise of exponential process (EP).

Similarly, many authors discussed the control charts with healthcare data. For example, Koetsier et al.37 suggested control chart for healthcare system. Similarly, Suman and Prajapati38 provided a detailed review of control charts for health sector. Likewise, Waqas et al.39 highlighted the control charts with COVID data. Also, Aslam et al.40 suggested HWMA chart for breast cancer data. For more detailed studies, see27,36,41,42.

In contemporary discussions surrounding memory control charts, the significance of steady-state (SS) performance surpasses that of zero-state (ZS) performance43. As previously noted Rasheed, et al. 44 introduced Inline graphiccontrol chart for EP, relying solely on ZS criteria.

Similarly, all the previous control charts about the exponential process are related to ZS performance evaluation criteria. In addition, if you’re looking for a substitute for EWMA control charts that can effectively monitor any process, CUSUM charts are a great option45. Additionally, the crosier CUSUM (CCUSUM) chart was introduced by Crosier46 as a substitute for the CUSUM mean chart. He suggested that the CCUSUM chart demonstrates greater efficiency compared to the CUSUM chart. With these considerations discussed above, the present research aims to offer two new exponential distributions based CUSUM and CCUSUM control charts (presented byInline graphic and Inline graphic) that outperform its predecessors, considering the quality measures of both ZS and SS. A number of different metrics are utilized in order to assess the suggested Inline graphic chart. The measures encompass the Average, median, and standard deviation of run length (RL) (symbolized as ARL, MDRL, and SDRL). Similarly, the relative ARL (RARL), Extra Quadratic Loss (EQL), and performance Comparison Index (PCI) are also used for overall performance measures. In addition, to underscore the real-life significance of the suggested Inline graphic and Inline graphic charts, two real-world applications from breast cancer (BC) and urinary tract infection (UTI) are presented.

The ensuing sections of this manuscript are organized as: Sections “Design structure of existing control chart” and “Proposed control charts” delineate the current methodologies as well as the proposed alternatives. Section “Assessment of performance” delineates the metrics for assessing performance. Section “ Additionally, Section “Performance comparisons” presents a comparative analysis, whereas Section “Practical application” illustrates the practical usage of the proposals. The findings and recommendations are the components that make up the final part.

Design structure of existing control chart

Suppose, the quality characteristic (QC) of interest (t), which follows an ED with a mean represented by θ, defined by the subsequent probability distribution function.

graphic file with name d33e822.gif 1

If T follows an ED with parameter θ, then Inline graphicdefined as T raised to the power of Inline graphic, adheres to a Weibull distribution characterized by shape and scale parameters Inline graphic and Inline graphic, respectively47. Inline graphicapproximates a normal variate for shape parameter 3.6.48, i.e. Inline graphic Inline graphic for Inline graphic.

Assume the process is beginning in a controlled condition., i.e. Inline graphic. In order to construct an EWMAInline graphic control chart employing probability limits, the altered variable Inline graphic. was used by Aslam et al.47. Later, Rasheed et al.36 presented an additional transformation i.e., Inline graphic, which converts Inline graphic into standard normal variate. Rasheed et al.36 proposed the following Inline graphic statistic

graphic file with name d33e918.gif 2

Here Inline graphic. The control limits of Inline graphic are by assuming Inline graphic

graphic file with name d33e935.gif 3

where L is responsible for reaching the desired IC ARL. The process is considered OOC whenever plotting statistic is less than the Inline graphic or greater than the Inline graphic; otherwise, it is deemed to be in the IC.

Proposed control charts

This section presents the suggested charts derived from the modified variable Y. The CUSUM control chart for ED presented as Inline graphic chart. The Inline graphic statistics are presented as

graphic file with name d33e967.gif 4

Here, the Inline graphic represents the reference value, generally consists of about 50% of the shifts. Moreover, Inline graphic are supposed to be 0. The Inline graphic chart signals an OOC condition when either of the two statistics Inline graphic or Inline graphicexceeds the Inline graphic. Crosier46 proposed an altered variant of the CUSUM mean chart, presented as the CCUSUM chart. The CCUSUM chart operates in a manner that is comparable to that of the CUSUM chart; hence, it is more responsive. The CCUSUM chart is equally useful for multivariate data because it may be used to keep track of more than one quality attribute at a time. The CCUSUM chart for exponential process (Inline graphic) depends on the following statistics;

graphic file with name d33e1006.gif 5

and

graphic file with name d33e1012.gif 6

where Inline graphic= 0. The parameter Inline graphic represents the reference value for the Inline graphic chart, analogous to its function within the Inline graphic chart. It is very common to set Inline graphic to be half of the shifts when identifying the average change of size Inline graphic. The Inline graphic chart generates an OOC points under the condition that Inline graphic exceeds Inline graphic or falls below - Inline graphic, spoting a shift in the process, either upward or downward. The parameter Inline graphic delineates the rate of false alarms associated with the Inline graphic chart.

Assessment of performance

To assess the efficacy of the control charts, we will offer the various performance evaluation criteria here. The subsequent subsections provide additional detailed information.

Monte Carlo simulation

We use an exponential distribution with a variety of parameter choices to produce sample of Inline graphic, where Inline graphic = 1,2,.,n. Subsequently, calculate the required statistical measures for the chart’s plotting statistic. The following is an indication of the shift in the process parameter: Inline graphic to Inline graphic, where Inline graphic is given in Tables A1–A4. The R software program serves as a platform for the development of an algorithm. For every single displacement of shift, a Monte Carlo simulation with 100,000 iterations carried out. The simulation process for the proposed control charts is presented in the following manner.

  1. For the purpose of generating samples, the exponential distribution given in Eq. (1) is utilized.

  2. The previous sample is used to calculate the transformed variable.

  3. Afterwards, the Inline graphic and Inline graphicstatistics should be computed by employing the use of the variable Inline graphic.

  4. The pertinent decision intervals have been approximated.

  5. Plot the associated decision intervals against the Inline graphic and Inline graphicstatistics.

  6. If either the Inline graphic or Inline graphic statistic fall out of the h, then note that sample number because it is a RL.

  7. Do steps 1 to 5 100,000 times, keeping an eye on the RLs on every occasion.

  8. Find the mean of 100,000 different RLs to find the Inline graphicvalue.

  9. Ultimately, ARLs for different number of samples and parameter combinations are determined.

  10. Repeat steps 1 through 9 after gathering additional samples under shift from the corresponding distribution to ascertain the Inline graphicvalues.

ARL measure

Among the many metrics to assess the performance of a control chart over a shift, the ARL indicator is among the most popular and well-known. There are two types of symbolized named as Inline graphic and Inline graphic. The number of false alarms that could occur when a process was in an IC state was reduced with an appropriately sized Inline graphic. Still, the Inline graphic needs to be very little to notice the change rapidly. For a control chart to be more effective, it must have a lower Inline graphic at the same Inline graphic level.

Indicators for evaluating overall performance

The EQL, RARL, and PCI indicators of performance can be used to determine the total effectiveness of a control chart. Additional details are provided here. The RARL is widely employed for evaluating OP of a control chart. The RARL is documented as.

Inline graphic  

Additionally, the ARLs of the competitor and BM charts are represented by the ARL(δ) and Inline graphic respectively. At a particular Inline graphic, a chart is considered to be a BM if it has a lower ARL than other control charts49. At this point, it is assumed that the RARL value included within the BM chart is equal to one. If the RARL value is larger than 1, the BM chart is thought to be better than the competing chart.

The EQL is calculated by averaging the ARL across all shifts using Inline graphic squared as the weighting factor50. Mathematically, it is written as.

Inline graphic

where Inline graphic and Inline graphic represent the maximum and minimum deviations of the range, respectively. As far as control charts are concerned, the one with the lowest EQL is clearly the best.

The PCI is another indicator used here and its definition is.

Inline graphic

In the event that the PCI is bigger than 1, the BM chart outperforms the competing control chart51.

IC behaviour of Inline graphic and Inline graphic charts

The parameters Inline graphic andInline graphic serve as the foundation for IC behaviour of the Inline graphic and Inline graphic charts. To conduct the simulation study for the fixed sample size 1, the values of Inline graphic are established as 0.10, 0.25, 0.50, 0.75, 1.0, 1.5, 2.0, and 2.5 (see52 and53). Subsequently, each Inline graphic value is utilized to calculate the control limit Inline graphic, ensuring that the target Inline graphic approximates 200 and 370. Tables A1–A4 and A8–A11 display the RL matrices of the Inline graphic and Inline graphic charts. The following are the primary conclusions drawn from the suggested the Inline graphicand Inline graphiccharts:

  • The RL distributions of the Inline graphicand Inline graphiccharts exhibit a positive skewness (refer to Tables A1 and A3).

  • In the context of the proposed Inline graphicand Inline graphic charts, it is noted that the SDRL values are less than the ARL, as highlighted in Tables A1–A4.

  • In order to get IC ARL 200 and 370, theInline graphic value reduces as Inline graphic increases. For example, Inline graphic value decreases from 7.974, 5.79 and 3.75, the values of Inline graphic increases from 0.10 to 0.25, 0.50 respectively, in the Inline graphic chart withInline graphic=1 and Inline graphic.

OOC behaviour of Inline graphic and Inline graphiccharts

To assess the OOC behavior of the Inline graphic charts with sample size 1 and an ARL of 200 and 370, various combinations of design parameters will be examined. We used a range of Inline graphic values, including 1.0, 1.05, 1.10, 1.15, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 3.0, 4.0, 5.0, and 6.0, to examine the OOC behavior. Tables A1–A4 and A8–A11, respectively, show the RL behaviour under OOC criteria for the suggested control chart. Furthermore, the comprehensive performance metrics for the proposed versus existing competitors’ charts have been figured and are presented in Table A15. The findings presented in Tables A1–A4 and A8–A11 yield a series of conclusions articulated as follows.

  • The proposed control charts demonstrate enhanced efficacy for lower values of k regarding the RL characteristics (refer to Figs. 1 and 2).

  • The Inline graphic of Inline graphicand Inline graphic charts decline with the rise in the k values. As an illustration, when Inline graphic rises by 0.01 to 2.00, the Inline graphic control chart reaches the Inline graphic values of 186.81, 200.49, 217.60, 228.54, 233.46, 245.38, 249.23, respectively, in the SS condition for Inline graphic = 0.10, Inline graphic = 370 (see Table A11).

  • Table A15 specifies the Inline graphic control chart overall best in term of performance when Inline graphic approaches the smallest value i.e., 0.10.

Fig. 1.

Fig. 1

Inline graphicchart for various Inline graphic using Inline graphic.

Fig. 2.

Fig. 2

Inline graphicchart for various Inline graphic using Inline graphic.

Performance comparisons

The ZS and SS comparisons between the proposed and existing charts are provided in this section. The comparisons are performed at Inline graphic200, 370. The subsequent subsections contain more information on the contrasting results.

Zero state performance comparison with Inline graphic and Inline graphic charts

The comparison of ZS is based on the assumption that the shift is happening at the beginning of the process. Tables A1–A7 display the ZS RL outcomes for specific shifts linked to Inline graphic, Inline graphic, Inline graphic, and Inline graphic control charts for Inline graphic = 200, 370. Table A15 presents the measures that are employed to appraise the OP under the assumption that ZS is present.

When equated to the existing Inline graphic and Inline graphic control charts, the suggested Inline graphicand Inline graphic charts are effective at tracking moderate and minor shifts. For example, at shifts 1.05,1.10, 1.15 and Inline graphic = 200Inline graphic the Inline graphic and Inline graphic provide the Inline graphic values (133.69, 98.33, 75.00) and (115.27, 79.00,59.05), whereas the existing Inline graphic control chart (Inline graphic has theInline graphic value equal to (171.68, 127.09, 95.89) and Inline graphic chart has Inline graphic values (181.56, 149.93, 122.84) (see Table A1–A2 vs. Table A5–A7). Figures 3, 4, 5 and 6 also show the relative advantages of suggested Inline graphic and Inline graphic charts over Inline graphic and Inline graphic control charts practically.

Fig. 3.

Fig. 3

Inline graphic and Inline graphic charts under Inline graphic = 370.

Fig. 4.

Fig. 4

Inline graphic and Inline graphic charts under Inline graphic.

Fig. 5.

Fig. 5

Inline graphic and Inline graphic charts under Inline graphic = 370.

Fig. 6.

Fig. 6

Inline graphic and Inline graphic charts under Inline graphic = 370.

Moreover, the proposed Inline graphic and Inline graphiccontrol charts keep their priority by keeping the smaller SDRL than the Inline graphic and Inline graphic. For instance, with shifts 1.05, 1.15, and Inline graphic= 370, the proposed Inline graphic and Inline graphic control charts at the common Inline graphic = 0.1 provide the Inline graphic values (Inline graphic) and (191.80, 77.05), whereas the Inline graphic control chart (Inline graphic has theInline graphic value (308.14, 146.24) and Inline graphic chart has Inline graphic values (Inline graphic) (see Tables A2, A4, A6, A7).

The proposed Inline graphic and Inline graphic charts outperform the current Inline graphic and Inline graphic charts, according to the OP metrics under ZS. For instance, Inline graphicchart and Inline graphic has Inline graphic, Inline graphic, and Inline graphic values are 107.84, 1.23, 1.29 and 87.33,1.00,1.00, whereas the Inline graphic Inline graphic and Inline graphic control charts have 118.21, 1.35, 1.29 and 171.31, 1.96, 2.09, respectively (see Table A15). According to the ZS criteria, the Inline graphic chart outperforms the others when comparing overall performance.

Steady state performance comparison with Inline graphic and Inline graphic charts

The SS performance assessment criterion is restored than the ZS criterion, as stated by Knoth et al.54. For the sake of SS, it is believed that the shift does not take place at the initial step of the process but rather at a future stage in the process. This subsection compares Inline graphic, Inline graphic, Inline graphic, and Inline graphic control charts using SS. Tables A8–A14 exhibit the RL outcomes of the control charts under the assumption of SS. The outcomes of the comparisons of overall performance in the SS area are detailed in Table A15.

Under the assumption of SS, the proposed Inline graphic and Inline graphic charts Achieve enhanced performance compared to the existing Inline graphic and Inline graphic charts to track tiny to medium shifts. Let us suppose, at Inline graphic andInline graphic the proposed Inline graphic and Inline graphic control charts for Inline graphic provide the Inline graphic values (159.92, 138.94) and (149.81, 128.00), whereas the Inline graphic control chart (Inline graphic has theInline graphicvalues (179.98, 155.40) and Inline graphic chart has Inline graphic values (192.65, 175.22) (see Table A8, A10 vs. Tables A12, A14). Similarly, the dominance of the suggested Inline graphicand Inline graphic charts against the Inline graphic and Inline graphic charts can also be observed through additional values within the tables. The SDRL performance is as essential when compared to the SS regardless of the presence of the ARL. The suggested Inline graphic and Inline graphic control charts are more advantageous than the Inline graphic and Inline graphic under Inline graphic criteria. As an example, with shifts 1.05, 1.10 and Inline graphic = 370, the Inline graphic and Inline graphic control charts with Inline graphic provide the Inline graphic values (197.92, 130.46) and (201.73, 129.13), whereas the Inline graphic control chart (Inline graphic has theInline graphic values (306.97, 241.83) and Inline graphic chart has Inline graphic values (301.28, 251.12) (see Tables A9, A11 vs. Tables A13, A14).

Moreover, in SS, theInline graphic and Inline graphic charts exhibit surpassed OP than the Inline graphic and Inline graphic charts. As an illustration, with the Inline graphic values of the Inline graphic and Inline graphic charts with Inline graphic are 291.53, 1.05, 1.05 and 277.25, 1.00, 1.00, suggesting a better overall performance against the Inline graphic Inline graphic and Inline graphic charts yield the values of 296.87, 1.04, 1.05 and 336.02, 1.17, 1.19, respectively (see Table A15). However, the Inline graphic chart is best than all others competitors for overall performance comparison criterion under SS.

Performance comparison under standard error of ARL

The standard error (SE) of ARL (SEARL) estimate is another criterion for assessing the performance of proposed with existing control charts. The SEARL of the Inline graphic, Inline graphic, Inline graphic and Inline graphic charts are presented in Table A1–A7. For small shift, the suggested Inline graphic and Inline graphic are more sensitive than the existing Inline graphic and Inline graphic charts. For example, at ARL = 200, SEARL of Inline graphic and Inline graphic charts decrease from 5.797 to 0.449 and 7.5 to 0.407 for the shifts 1–1.5 respectively. Similarly, SEARL of Inline graphic and Inline graphic charts decrease from 6.966 to 0.653 and 6.337 to 1.485, respectively. Likewise, at shift 2.5, the Inline graphic, Inline graphic, Inline graphic and Inline graphic charts provide SEARL values 0.142, 0.131, 0.167, and 0.291, respectively. For extremely large shifts like 4–6, the SEARL values are 0.05, 0.473, 0.50, 0.61 for the Inline graphic, Inline graphic, Inline graphic and Inline graphic charts respectively. Hence, the proposed Inline graphic and Inline graphic are more sensitive than Inline graphic and Inline graphic charts for the monitoring of small to large shifts in the exponential process. For extremely large shifts, Inline graphic chart is also performing good.

Practical application

In order to demonstrate the potential real-world applications of the suggested Inline graphic and Inline graphic charts, this section offers two case studies. Analyses of breast cancer survival rates are presented in Section “Application with BC data”, while a data set pertaining to UTIs is used in Section “Application with urinary tract infection data” for practical purposes. complications. The proposed control charts are highly beneficial for keeping an eye on patients in a clinical context since they can notice changes in a patient’s health early on. For example, these charts let doctors look at patient health data in BC survival monitoring to discover early signals of therapy failure or negative occurrences. For UTIs, they can keep track of how many people get sick over time and let people know early about possible outbreaks or treatment resistance. This is vital for both taking care of patients and responding to public health issues. Adding these charts to their clinical systems lets healthcare providers see real-time updates on their patients’ health. Patients obtain the proper treatment at the right time and the right modifications are made, which leads to improved outcomes. The proposed charts are meant to help with early action in healthcare by spotting minor changes in important health indicators like infection rates or patient survival data. This gives healthcare workers a chance to respond before a patient’s condition gets worse, which could minimize the risk of mortality and the overall expense of the sickness. For figuring out how long people with cancer will live, noticing tendencies that are getting worse early on might lead to swift changes in treatment plans that will help patients get well. In the same way, learning about increased incidence of urinary tract infections early on can lead to earlier isolation measures, which will halt infections from spreading in hospitals and improve the total level of care.

Application with BC data

BC is the utmost harmful and fastest spreading non-metastatic illness among women around the world. If it is caught early, 70–80% of the time it can be treated successfully23. A serious global threat has been brought to light by the fact that around 17 lac new instances of BC have been reported per year over the course of the past five years55. Irrespective of the nation’s economic status, breast cancer imposes challenges in early detection, prevention, and treatment. Poor nations still don’t have what it takes for early detection, effective treatment, and preventative screening, which explains why their death toll is climbing despite falling incidence rates. Because it is a vicious and quickly kills millions of people per year, we must do all in our power to find ways to prevent, detect, and treat the disease quickly so that we can lessen its impact and increase survival rates.

This particular example evaluates the dataset that was compiled by Awodutire et al.56, which displays the length of time that the patients of this epidemic had survived. Ladoke Akinotola University in Nigeria was the location where breast cancer patients were treated between the years 2000 and 2014. This information was collected from those patients. In addition, Awodutire et al.56 found that these data are best represented by the exponential distribution.

The Inline graphic and Inline graphic tools are applied in combination with the existing Inline graphic control chart to analyze this data. Providing a way to track the death rate of breast tumor patients is the main goal of this program.

This will facilitate the development of practical preventive measures, bolster the establishment of campaigns for the promotion of public health, lessen the impact of the illness and improve chances of survival. The analysis reveals a satisfactory alignment, as evidenced by a KS statistic of Inline graphic and a Inline graphic, indicating that these data are consistent to ED. The fitness can also be seen in Q-Q plot and empirical versus fitted CDF graph in Figs. 7 and 8.

Fig. 7.

Fig. 7

Q-Q plot of BC data.

Fig. 8.

Fig. 8

Empirical verses fitted CDF plot of BC data.

To execute the proposed and existing control charts, the IC Inline graphic is set at 104.67 as an mean of the sample by following Anwar et al.53. The initial 30 samples are designated as IC, while a little shift 1.16 is applied to the remaining samples, as documented in existing studies53,57. The parameters arrangement of various control charts are assumed as under: For the Inline graphic (Inline graphic = 0.25, Inline graphic = 5.79), for Inline graphic (Inline graphic =  0.1, Inline graphic =  2.694), and Inline graphic (Inline graphic = 0.25, Inline graphic = 7.68) with prespecified Inline graphic.

The data presented in Figs. 11, 12 and 13 reveal that the proposed Inline graphic, Inline graphic, Inline graphic charts display the first OOC indication at 47, 45, and 49, respectively. In a similar way the Inline graphic reveals merely two OOC points, whereas the proposed Inline graphic and Inline graphiccontrol charts detect four and five OOC points, respectively. The findings suggest the suggested charts demonstrate higher sensitivity in identifying minor variations in process when contrasted with the Inline graphic control chart.

Fig. 11.

Fig. 11

The implementation of the Inline graphic chart for cancer data when Inline graphic.

Fig. 12.

Fig. 12

The implementation of the Inline graphic chart for cancer data when Inline graphic.

Fig. 13.

Fig. 13

The implementation of the Inline graphic chart using cancer data for Inline graphic.

Application with urinary tract infection data

This segment offers a practical implementation of the Inline graphic and Inline graphic charts employing the UTI sample (quantified in ng/ml). Khan et al.31 utilized this real-life sample for the montoring the EP in past. The findings suggest that the number of UTIs that occur in male patients after they leave the hospital is on the rise, with an average duration of 0.21 days. It is possible for the symptoms of a UTI to differ depending on a number of factors, such as age, gender, and financial situation, in addition to unique risk factors for UTIs that are only found in women. In comparison to their male counterparts, the urethras of females exhibit a distinct reduction in size. This directly minimizes the distance that pathogens need to traverse to reach the bladder. Engagement in sexual activity has been associated with a heightened occurrence of urinary tract infections. The utilization of diaphragms as a contraceptive method could potentially increase the likelihood of urinary tract infections. Moreover, the potential for risk is markedly heightened in the presence of an unexpected companion of sexual activity. Mostly, the medical centers seeks to systematically track the occurrence of patients who are released following the onset of a urinary tract infection during their hospitalization. This initiative is designed to swiftly detect any rises in infection rates and to evaluate the effects of upcoming procedural or material changes on the mitigation of infections. Table A13 presents the data pertaining to UTIs. The KS test is performed for evaluating the adequacy of data implementation. The KS = 8.259 (p-value = 0.25) show that the outcomes align with an study distribution, indicating a satisfactory fit (also see Q-Q plot and empirical versus fitted CDF graph in Figs. 9 and 10).

Fig. 9.

Fig. 9

Q-Q plot of UTI data.

Fig. 10.

Fig. 10

Empirical versus fitted CDF of UTI data.

In order to account for OOC performance, a shift of 1.22 was applied across the last fifteen samples, with the first fifteen serving as an IC. In this case, the Inline graphic chart is designed for k = 0.50, h = 3.75, L = 2.825, λ = 0.2 for Inline graphic chart, and k = 0.50, h = 4.685 for Inline graphic chart at prespecified Inline graphic.

The initial OOC spots are found at 18th sample both for Inline graphic and Inline graphiccharts, but at the 25th sample on the Inline graphic chart (Figs. 14, 15 and 16). Furthermore, the suggested Inline graphic, Inline graphicand Inline graphic charts validate eleven, twelve, and two OOC signals, respectively. This illustrates that the Inline graphic and Inline graphiccharts exhibit higher performance compared to existing Inline graphic chart.

Fig. 14.

Fig. 14

The implementation of the Inline graphicchart for UTI data.

Fig. 15.

Fig. 15

The implementation of the Inline graphicchart using UTI data.

Fig. 16.

Fig. 16

The implementation of the Inline graphicchart for UTI data.

Final remarks and suggestions

In order to track the EP in both ZS and SS conditions, this research suggests using two control charts: CUSUM and crosier CUSUM (CCUSUM). The suggested charts are presented as Inline graphic and Inline graphic to spot the shifts in the EP efficiently and effectively. Numerical outcomes are obtained using the Monte Carlo simulations. Famous performance measures like ARL, MDRL, and SDRL are employed to track the individual shifts in the process. Similarly, for the monitoring of overall performance, different performance indicators like EQL, PCI, and RARL are obtained. The aforementioned performance metrics are used to compare the suggested charts with well-known exponential-based charts such as Inline graphic and Inline graphic. Based on the contrasts, it appears that the suggested Inline graphic and Inline graphiccharts outperform the rival charts regarding SS and ZS conditions. Similarly, both suggested control chart’s SS and ZS ARL and SDRL are contrasted. The Inline graphic and Inline graphiccharts have minimum ARL and SDRL values under ZS as compared to SS. Similarly, the Inline graphic chart has higher quality outcomes compared to the Inline graphic chart under ZS and SS criterions. Lastly, the suggested charts are put into practice using two true data sets regarding the health care sector. Furthermore, the results of true data indicate the suggested charts are superior to the existing rivals. This research can be additionally prolonged to include other abnormal distributions like Weibull and Gamma and multivariate scenarios.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary Material 1 (223.4KB, docx)

List of symbols

ZS

Zero-state

SPC

Statistical process control

CCUSUM

Crosier CUSUM

EP

Exponential process

Inline graphic

CCUSUM for EP

Inline graphic

CUSUM for EP

PCI

Performance comparison index

RARL

Relative ARL

BC

Breast cancer

AEWMA

Adaptive EWMA

OOC

Out-of-control

QC

Quality characteristic

Inline graphic

Improved EWMA for EP

Inline graphic

Transformed variable

Inline graphic

Lower control limit of Inline graphic  

Inline graphic

Upper Inline graphic

Inline graphic

Inline graphic parameter

Inline graphic

Inline graphic statistic

Inline graphic

OOC ARL

BM

Benchmark

ARL(δ)

ARL at Inline graphic

Inline graphic

Maximum Inline graphic

KS

Kolmogorov-Smirnov

SS

Steady-state

CUSUM

Cumulative sums

ED

Exponential distribution

RL

Run length

ARL

Average RL

SDRL

Standard deviation RL

MDRL

Median RL

EQL

Extra quadratic loss

UTI

Urinary tract infection

DEWMA

Double EWMA

IC

In-control

Inline graphic

Inline graphic parameter

Inline graphic

Inline graphic statistic

L

Inline graphic limit constant

Inline graphic

Upper control limit of Inline graphic

Inline graphic

Lower Inline graphic

Inline graphic

Decision interval

Inline graphic

Shift

OP

Overall performance

Inline graphic

IC ARL

Inline graphic

ARL of BM at Inline graphic

Inline graphic

Minimum Inline graphic

CDF

Cumulative distribution function

Author contributions

S. M. A., N. A., and C-Y. L. participated in composing the initial text, executing mathematical investigations, and carrying out computer-based results. N. A. authenticated all findings, reorganized the text, and oversaw financial procurement. All authors examined and sanctioned the last draft of the article.

Funding

The contributors would like to express their gratitude to King Khalid University's Deanship of Research and Graduate Studies for providing financial support for this project through the Large Research Project (RGP2/50/46), and to National Chung Hsing University for financial support through the National Science and Technology Council (Taiwan) project (Project No. NSTC 113-2118-M-005-004-MY3).

Data availability

Upon appropriate request, the datasets utilized and/or evaluated for this investigation could be acquired by contacting the relevant authors.

Declarations

Competing interests

The authors declare no competing interests.

Footnotes

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Syed Masroor Anwar, Email: masroor.anwar@ajku.edu.pk.

Chang-Yun Lin, Email: chlin6@nchu.edu.tw.

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Material 1 (223.4KB, docx)

Data Availability Statement

Upon appropriate request, the datasets utilized and/or evaluated for this investigation could be acquired by contacting the relevant authors.


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