Abstract
Different doses of intravenous cocaine reinforced the lever pressing of rhesus monkeys under two-lever concurrent or concurrent-chain schedules. Under the concurrent procedure, responding produced drug reinforcers arranged according to independent variable-interval 1-min schedules. Under the concurrent-chain procedure, responding in the variable-interval link led to one of two mutually exclusive, equal-valued, fixed-ratio links; completion of the ratio produced a drug reinforcer. Under both procedures, responding on one lever produced a constant dose of 0.05 or 0.1 mg/kg/injection, while on the other lever, dose was systematically varied within a range of 0.013 to 0.8 mg/kg/injection. Preference, indicated by relative response frequency on the variable-dose lever during the variable-interval link, was always for the larger of the doses. Relative response frequencies on the variable-dose lever roughly matched relative drug intake (mg/kg of drug obtained on variable lever divided by mg/kg of drug obtained on both levers). For many dose comparisons, responding occurred and reinforcers were obtained almost exclusively on the preferred lever. Overall variable-interval rates generally were lower than with other reinforcers, and these low rates, under the experimental conditions, may have occasioned the exclusive preferences.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Balster R. L., Schuster C. R. Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. J Exp Anal Behav. 1973 Jul;20(1):119–129. doi: 10.1901/jeab.1973.20-119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baum W. M., Rachlin H. C. Choice as time allocation. J Exp Anal Behav. 1969 Nov;12(6):861–874. doi: 10.1901/jeab.1969.12-861. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brownstein A. J. Concurrent schedules of response-independent reinforcement: duration of a reinforcing stimulus. J Exp Anal Behav. 1971 Mar;15(2):211–214. doi: 10.1901/jeab.1971.15-211. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CATANIA A. C. Concurrent performances: a baseline for the study of reinforcement magnitude. J Exp Anal Behav. 1963 Apr;6:299–300. doi: 10.1901/jeab.1963.6-299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CATANIA A. C. Concurrent performances: reinforcement interaction and response independence. J Exp Anal Behav. 1963 Apr;6:253–263. doi: 10.1901/jeab.1963.6-253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chung S. H., Herrnstein R. J. Choice and delay of reinforcement. J Exp Anal Behav. 1967 Jan;10(1):67–74. doi: 10.1901/jeab.1967.10-67. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davis A. H., Davison M. C., Webster D. M. Intracranial reinforcement in pigeons: an analysis using concurrent schedules. Physiol Behav. 1972 Sep;9(3):385–390. doi: 10.1016/0031-9384(72)90164-3. [DOI] [PubMed] [Google Scholar]
- Deneau G., Yanagita T., Seevers M. H. Self-administration of psychoactive substances by the monkey. Psychopharmacologia. 1969;16(1):30–48. doi: 10.1007/BF00405254. [DOI] [PubMed] [Google Scholar]
- Dougherty J., Pickens R. Fixed-interval schedules of intravenous cocaine presentation in rats. J Exp Anal Behav. 1973 Jul;20(1):111–118. doi: 10.1901/jeab.1973.20-111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fantino E., Squires N., Delbrück N., Peterson C. Choice behavior and the accessibility of the reinforcer. J Exp Anal Behav. 1972 Jul;18(1):35–43. doi: 10.1901/jeab.1972.18-35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GUTTMAN N. Operant conditioning, extinction, and periodic reinforcement in relation to concentration of sucrose used as reinforcing agent. J Exp Psychol. 1953 Oct;46(4):213–224. doi: 10.1037/h0061893. [DOI] [PubMed] [Google Scholar]
- Goldberg S. R. Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J Pharmacol Exp Ther. 1973 Jul;186(1):18–30. [PubMed] [Google Scholar]
- Goldberg S. R., Hoffmeister F., Schlichting U. U., Wuttke W. A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: effects of dose and fixed-ratio parameter. J Pharmacol Exp Ther. 1971 Nov;179(2):277–283. [PubMed] [Google Scholar]
- HERRNSTEIN R. J. Relative and absolute strength of response as a function of frequency of reinforcement. J Exp Anal Behav. 1961 Jul;4:267–272. doi: 10.1901/jeab.1961.4-267. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herrnstein R. J. On the law of effect. J Exp Anal Behav. 1970 Mar;13(2):243–266. doi: 10.1901/jeab.1970.13-243. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KEESEY R. E., KLING J. W. Amount of reinforcement and free-operant responding. J Exp Anal Behav. 1961 Apr;4:125–132. doi: 10.1901/jeab.1961.4-125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Killeen P. The matching law. J Exp Anal Behav. 1972 May;17(3):489–495. doi: 10.1901/jeab.1972.17-489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neuringer A. J. Effects of reinforcement magnitude on choice and rate of responding. J Exp Anal Behav. 1967 Sep;10(5):417–424. doi: 10.1901/jeab.1967.10-417. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pickens R., Thompson T. Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Ther. 1968 May;161(1):122–129. [PubMed] [Google Scholar]
- Pliskoff S. S., Hawkins T. D. A method for increasing the reinforcement magnitude of intracranial stimulation. J Exp Anal Behav. 1967 May;10(3):281–289. doi: 10.1901/jeab.1967.10-281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rachlin H., Baum W. M. Response rate as a function of amount of reinforcement for a signalled concurrent response. J Exp Anal Behav. 1969 Jan;12(1):11–16. doi: 10.1901/jeab.1969.12-11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rachlin H. On the tautology of the matching law. J Exp Anal Behav. 1971 Mar;15(2):249–251. doi: 10.1901/jeab.1971.15-249. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEBBINS W. C., MEAD P. B., MARTIN J. M. The relation of amount of reinforcement to performance under a fixed-in-terval schedule. J Exp Anal Behav. 1959 Oct;2:351–355. doi: 10.1901/jeab.1959.2-351. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwartz B. Effects of reinforcement magnitude on pigeons' preference for different fixed-ratio schedules of reinforcement. J Exp Anal Behav. 1969 Mar;12(2):253–259. doi: 10.1901/jeab.1969.12-253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shull R. L., Pliskoff S. S. Changeover delay and concurrent schedules: some effects on relative performance measures. J Exp Anal Behav. 1967 Nov;10(6):517–527. doi: 10.1901/jeab.1967.10-517. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ten Eyck R. L. Effects of rate of reinforcement-time upon concurrent operant performance. J Exp Anal Behav. 1970 Nov;14(3):269–274. doi: 10.1901/jeab.1970.14-269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilson M. C., Hitomi M., Schuster C. R. Psychomotor stimulant self administration as a function of dosage per injection in the rhesus monkey. Psychopharmacologia. 1971;22(3):271–281. doi: 10.1007/BF00401789. [DOI] [PubMed] [Google Scholar]