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Journal of the Experimental Analysis of Behavior logoLink to Journal of the Experimental Analysis of Behavior
. 1973 Jul;20(1):111–118. doi: 10.1901/jeab.1973.20-111

Fixed-interval schedules of intravenous cocaine presentation in rats1

John Dougherty, Roy Pickens
PMCID: PMC1334108  PMID: 4714574

Abstract

Fixed-interval schedules of intravenous cocaine presentation were examined as a function of injection dose (0.32 to 0.64 mg/kg) and interval duration (200 to 400 sec) in two rats. Cocaine was found to exert a dose-related temporal control over the initiation of responding that was unaffected by the fixed-interval contingency. Fixed-interval pause duration was linearly related to injection dose and was the same duration as the interresponse time found on continuous reinforcement schedules of cocaine presentation. The fixed-interval pause remained constant with changes in interval duration. Characteristic fixed-interval patterns of responding were observed. However, overall response rates were inversely related to injection dose and directly related to interval duration. Running response rates varied unsystematically with both variables. These findings are at variance with results typically found in studies of fixed-interval food and electric shock presentation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COLLIER G., WILLIS F. N. Deprivation and reinforcement. J Exp Psychol. 1961 Oct;62:377–384. doi: 10.1037/h0047144. [DOI] [PubMed] [Google Scholar]
  2. Catania A. C., Reynolds G. S. A quantitative analysis of the responding maintained by interval schedules of reinforcement. J Exp Anal Behav. 1968 May;11(3 Suppl):327–383. doi: 10.1901/jeab.1968.11-s327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FRY W., KELLEHER R. T., COOK L. A mathematical index of performance on fixed-interval schedules of reinforcement. J Exp Anal Behav. 1960 Jul;3:193–199. doi: 10.1901/jeab.1960.3-193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HUTT P. J. Rate of bar pressing as a function of quality and quantity of food reward. J Comp Physiol Psychol. 1954 Jun;47(3):235–239. doi: 10.1037/h0059855. [DOI] [PubMed] [Google Scholar]
  5. Innis N. K., Staddon J. E. Temporal tracking on cyclic-interval reinforcement schedules. J Exp Anal Behav. 1971 Nov;16(3):411–423. doi: 10.1901/jeab.1971.16-411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MECHNER F., GUEVREKIAN L., MECHNER V. A fixed interval schedule in which the interval is initiated by a response. J Exp Anal Behav. 1963 Jul;6:323–330. doi: 10.1901/jeab.1963.6-323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McKearney J. W. Fixed-interval schedules of electric shock presentation: extinction and recovery of performance under different shock intensities and fixed-interval durations. J Exp Anal Behav. 1969 Mar;12(2):301–313. doi: 10.1901/jeab.1969.12-301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pickens R., Thompson T. Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Ther. 1968 May;161(1):122–129. [PubMed] [Google Scholar]
  9. REYNOLDS R. W. The relationship between stimulation voltage and rate of hypothalamic self-stimulation in the rat. J Comp Physiol Psychol. 1958 Apr;51(2):193–198. doi: 10.1037/h0048362. [DOI] [PubMed] [Google Scholar]
  10. STEBBINS W. C., MEAD P. B., MARTIN J. M. The relation of amount of reinforcement to performance under a fixed-in-terval schedule. J Exp Anal Behav. 1959 Oct;2:351–355. doi: 10.1901/jeab.1959.2-351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schneider B. A. A two-state analysis of fixed-interval responding in the pigeon. J Exp Anal Behav. 1969 Sep;12(5):677–687. doi: 10.1901/jeab.1969.12-677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shull R. L. Sequential patterns in post-reinforcement pauses on fixed-interval schedules of food. J Exp Anal Behav. 1971 Mar;15(2):221–231. doi: 10.1901/jeab.1971.15-221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Staddon J. E. Effect of reinforcement duration on fixed-interval responding. J Exp Anal Behav. 1970 Jan;13(1):9–11. doi: 10.1901/jeab.1970.13-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. WEISS B., LATIES V. G. Magnitude of reinforcement as a variable in thermoregulatory behavior. J Comp Physiol Psychol. 1960 Dec;53:603–608. doi: 10.1037/h0047935. [DOI] [PubMed] [Google Scholar]
  15. WILSON M. P. Periodic reinforcement interval and number of periodic reinforcements as parameters of response strength. J Comp Physiol Psychol. 1954 Feb;47(1):51–56. doi: 10.1037/h0057224. [DOI] [PubMed] [Google Scholar]

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