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Journal of the Experimental Analysis of Behavior logoLink to Journal of the Experimental Analysis of Behavior
. 1994 Jul;62(1):57–72. doi: 10.1901/jeab.1994.62-57

Behavioral and pharmacological modulation of respiration in rhesus monkeys.

L L Howell 1, A M Landrum 1
PMCID: PMC1334367  PMID: 8064213

Abstract

Changes in respiration associated with schedule-controlled behavior were determined in seated rhesus monkeys prepared with a pressure-displacement head plethysmograph for monitoring ventilation continuously during behavioral experiments. Subjects were trained to press a lever under fixed-ratio 40 and fixed-interval 300-s schedules of stimulus termination. Episodic increases in ventilation were closely associated with periods of responding under both schedules. Recurring episodes of increased ventilation occurred during fixed-ratio responding, and were separated by brief 10-s timeouts during which ventilation decreased. Under the fixed-interval schedule, both ventilation and response rate typically increased as the 300-s interval elapsed. The effects of cocaine, caffeine, and two adenosine agonists, 5'-N-ethylcarboxamidadenosine (NECA) and 2-(carboxyethylphenylamino)adenosine-5'-carboxamide (CGS 21680), on behavior and respiration were determined using a cumulative-dosing procedure. Drug-induced suppression of behavior eliminated the episodic increases in ventilation during the performance components of both schedules. Schedule-related increases in ventilation were compared to those produced by elevated levels of CO2 in inspired air. Exposure to 4% CO2 mixed in air increased ventilation in all subjects, and the combined effects of CO2 exposure and schedule-controlled responding on respiration appeared to be additive. The results suggest that behavioral activities may increase ventilation through increased metabolic demand and increased CO2 production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ader R. Experimentally induced gastric lesions. Results and implications of studies in animals. Adv Psychosom Med. 1971;6:1–39. [PubMed] [Google Scholar]
  2. Benson H., Herd J. A., Morse W. H., Kelleher R. T. Behavioral induction of arterial hypertension and its reversal. Am J Physiol. 1969 Jul;217(1):30–34. doi: 10.1152/ajplegacy.1969.217.1.30. [DOI] [PubMed] [Google Scholar]
  3. Benson H., Shapiro D., Tursky B., Schwartz G. E. Decreased systolic blood pressure through operant conditioning techniques in patients with essential hypertension. Science. 1971 Aug 20;173(3998):740–742. doi: 10.1126/science.173.3998.740. [DOI] [PubMed] [Google Scholar]
  4. Daly J. W., Bruns R. F., Snyder S. H. Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines. Life Sci. 1981 May 11;28(19):2083–2097. doi: 10.1016/0024-3205(81)90614-7. [DOI] [PubMed] [Google Scholar]
  5. Dews P. B., Herd J. A. Behavioral activities and cardiovascular functions: effects of hexamethonium on cardiovascular changes during strong sustained static work in rhesus monkeys. J Pharmacol Exp Ther. 1974 Apr;189(1):12–23. [PubMed] [Google Scholar]
  6. Engel B. T., Schneiderman N. Operant conditioning and the modulation of cardiovascular function. Annu Rev Physiol. 1984;46:199–210. doi: 10.1146/annurev.ph.46.030184.001215. [DOI] [PubMed] [Google Scholar]
  7. Forsyth R. P. Blood pressure responses to long-term avoidance schedules in the restrained rhesus monkey. Psychosom Med. 1969 Jul-Aug;31(4):300–309. doi: 10.1097/00006842-196907000-00003. [DOI] [PubMed] [Google Scholar]
  8. Goldberg S. R., Prada J. A., Katz J. L. Stereoselective behavioral effects of N6-phenylisopropyl-adenosine and antagonism by caffeine. Psychopharmacology (Berl) 1985;87(3):272–277. doi: 10.1007/BF00432706. [DOI] [PubMed] [Google Scholar]
  9. Halas E. S., Beardsley J. V., Sandlie M. E. Conditioned neuronal responses at various levels in conditioning paradigms. Electroencephalogr Clin Neurophysiol. 1970 May;28(5):468–477. doi: 10.1016/0013-4694(70)90272-5. [DOI] [PubMed] [Google Scholar]
  10. Harris A. H., Gilliam W. J., Findley J. D., Brady J. V. Instrumental conditioning of large-magnitude, daily, 12-hour blood pressure elevations in the baboon. Science. 1973 Oct 12;182(4108):175–177. doi: 10.1126/science.182.4108.175. [DOI] [PubMed] [Google Scholar]
  11. Herd J. A., Morse W. H., Kelleher R. T., Jones L. G. Arterial hypertension in the squirrel monkey during behavioral experiments. Am J Physiol. 1969 Jul;217(1):24–29. doi: 10.1152/ajplegacy.1969.217.1.24. [DOI] [PubMed] [Google Scholar]
  12. Howell L. L., Bergman J., Morse W. H. Effects of levorphanol and several kappa-selective opioids on respiration and behavior in rhesus monkeys. J Pharmacol Exp Ther. 1988 Apr;245(1):364–372. [PubMed] [Google Scholar]
  13. Howell L. L. Comparative effects of caffeine and selective phosphodiesterase inhibitors on respiration and behavior in rhesus monkeys. J Pharmacol Exp Ther. 1993 Aug;266(2):894–903. [PubMed] [Google Scholar]
  14. Howell L. L. Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys. J Pharmacol Exp Ther. 1993 May;265(2):971–978. [PubMed] [Google Scholar]
  15. Howell L. L., Morse W. H., Spealman R. D. Respiratory effects of xanthines and adenosine analogs in rhesus monkeys. J Pharmacol Exp Ther. 1990 Sep;254(3):786–791. [PubMed] [Google Scholar]
  16. Kelleher R. T., Morse W. H., Herd J. A. Effects of propranolol, phentolamine and methyl atropine on cardiovascular function in the squirrel monkey during behavioral experiments. J Pharmacol Exp Ther. 1972 Aug;182(2):204–217. [PubMed] [Google Scholar]
  17. Logan L., Carney J. M. Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites. Pharmacol Biochem Behav. 1984 Sep;21(3):375–379. doi: 10.1016/s0091-3057(84)80098-2. [DOI] [PubMed] [Google Scholar]
  18. Lundberg D. B., Breese G. R., Mueller R. A. Aminophylline may stimulate respiration in rats by activation of dopaminergic receptors. J Pharmacol Exp Ther. 1981 Apr;217(1):215–221. [PubMed] [Google Scholar]
  19. Mason J. W. The scope of psychoendocrine research. Psychosom Med. 1968 Sep-Oct;30(5 Suppl):565–575. doi: 10.1097/00006842-196809000-00019. [DOI] [PubMed] [Google Scholar]
  20. Mazzarelli M., Jaspar N., Zin W. A., Aranda J. V., Milic-Emili J. Dose effect of caffeine on control of breathing and respiratory response to CO2 in cats. J Appl Physiol (1985) 1986 Jan;60(1):52–59. doi: 10.1152/jappl.1986.60.1.52. [DOI] [PubMed] [Google Scholar]
  21. Morse W. H., Kelleher R. T. Schedules using noxious stimuli. I. Multiple fixed-ratio and fixed-interval termination of schedule complexes. J Exp Anal Behav. 1966 May;9(3):267–290. doi: 10.1901/jeab.1966.9-267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mueller R. A., Lundberg D. B., Breese G. R., Hedner J., Hedner T., Jonason J. The neuropharmacology of respiratory control. Pharmacol Rev. 1982 Sep;34(3):255–285. [PubMed] [Google Scholar]
  23. Ritz M. C., Lamb R. J., Goldberg S. R., Kuhar M. J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science. 1987 Sep 4;237(4819):1219–1223. doi: 10.1126/science.2820058. [DOI] [PubMed] [Google Scholar]
  24. Saunders J. G. Selective facilitation and inhibition of auditory and visual evoked responses during avoidance conditioning in cats. J Comp Physiol Psychol. 1971 Jul;76(1):15–25. doi: 10.1037/h0031045. [DOI] [PubMed] [Google Scholar]
  25. Snyder S. H., Katims J. J., Annau Z., Bruns R. F., Daly J. W. Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A. 1981 May;78(5):3260–3264. doi: 10.1073/pnas.78.5.3260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Spealman R. D. Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism. Psychopharmacology (Berl) 1988;95(1):19–24. doi: 10.1007/BF00212759. [DOI] [PubMed] [Google Scholar]
  27. Talan M. I., Engel B. T. Learned control of heart rate during dynamic exercise in nonhuman primates. J Appl Physiol (1985) 1986 Aug;61(2):545–553. doi: 10.1152/jappl.1986.61.2.545. [DOI] [PubMed] [Google Scholar]
  28. Trippenbach T., Zinman R., Milic-Emili J. Caffeine effect on breathing pattern and vagal reflexes in newborn rabbits. Respir Physiol. 1980 May;40(2):211–225. doi: 10.1016/0034-5687(80)90094-8. [DOI] [PubMed] [Google Scholar]
  29. Wenger G. R. Cumulative dose-response curves in behavioral pharmacology. Pharmacol Biochem Behav. 1980 Nov;13(5):647–651. doi: 10.1016/0091-3057(80)90007-6. [DOI] [PubMed] [Google Scholar]
  30. Wessberg P., Hedner J., Hedner T., Persson B., Jonason J. Adenosine mechanisms in the regulation of breathing in the rat. Eur J Pharmacol. 1984 Oct 30;106(1):59–67. doi: 10.1016/0014-2999(84)90678-2. [DOI] [PubMed] [Google Scholar]

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