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. 1975 Jun;15(6):577–590. doi: 10.1016/S0006-3495(75)85840-1

A transient excited state model for sodium permeability changes in excitable membranes.

E Jakobsson, C Scudiero
PMCID: PMC1334740  PMID: 1148360

Abstract

In this paper we explore the properties of a mathematical model for the passive sodium permeability system of excitable membranes. This model is distinguished by the explicit inclusion of a rate constant which depends not on instantaneous voltage, but on rate of voltage change. Actually, the model is a rather modest modification of the Hodgkin-Huxley model, but displays some behaviors which the H-H model does not. Among these behaviors are a pronounced inactivation shift (for certain parameter values), a difference between inactivation time constant as measured by turning off a sodium current under sustained depolarization and as measured by double pulse experiments, skip runs under sustained current stimulation, and accommodation to slowing rising currents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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